Protein Alignment Lgr4 and Igfals

DIOPT Version :10

• Sequence 1: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001351825.1
• Gene: Igfals / 16005
• MGIID: 107973
• Length: 638
• Species: Mus musculus
• Alignment Length: 520
• Identity: 125/520 - (24%)
• Similarity: 192/520 - (36%)
• Gaps: 145/520 - (27%)

  Fly    95 HCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEVDAKY------------WDHLYRKQPFGRHDN 147
            |..:..:.:..||||             ..:.|..|.|            |
Mouse    15 HSRSIGKALGNRANC-------------LSLTEPSAPYRGSPALVVLLAFW-------------- 52

  Fly   148 LRIGECL-------------WPNENFSCPCRGDE------ILCRFQQLTDIPERLPQHDLATLDL 193
            :.:|.|.             .|....:|.|..|:      :.|..:.||.:|:.:|....| |.|
Mouse    53 VALGPCYLQGTDPGASADAEGPQCPVTCTCSYDDYTDELSVFCSSRNLTQLPDSIPVSTRA-LWL 116

  Fly   194 TGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLAD--------NPLRTL--------- 241
            .|||..:|....|..|..:|.|.|:...:|.:...|...|.:        |.||:|
Mouse   117 DGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFRHTP 181

  Fly   242 ------------------------YMDD-----NKLPHLPEHFFPEGNQLSILILARNHLHHLKR 277
                                    ::.|     |.|..||:..|.....|..|:||.|.|.:|:.
Mouse   182 SLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQP 246

  Fly   278 SDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDP----------------- 325
            :....|.:|:||||..|.:.:.:|.||..||.|:.|||:.|.:..:.|
Mouse   247 ALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHN 311

  Fly   326 -------DRFPRTLLNLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNL 382
                   |.|| .||.||.|.||:|.|..:...|| ....|..|.|..||:..:.::||..|..|
Mouse   312 RVAGLLEDTFP-GLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQL 375

  Fly   383 QGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNV 447
            :.|.||:|:|....:.||..|.|::.:.|:||..::|...|.:.|..|..::..  |.|...:.:
Mouse   376 EVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLE--HSCLGRIRL 438

  Fly   448 RVCDPHGDGISS--KLHLLDNQILRGSVWVMASIA------VVGNLLVLLGRYFYKSRSNVEHSL 504
            ...    .|:|.  :|.|.||.|.......:|.::      :..|.|..|.|..::....:|:.|
Mouse   439 HTF----AGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYLL 499

  Fly   505  504
            Mouse   500  499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011	5/28 (18%)
		LRR	167..>430	CDD:443914	94/339 (28%)
		leucine-rich repeat	188..211	CDD:275380	9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	9/60 (15%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		leucine-rich repeat	286..309	CDD:275380	10/22 (45%)
		leucine-rich repeat	310..334	CDD:275380	10/47 (21%)
		leucine-rich repeat	335..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..427	CDD:275380	5/20 (25%)
		7tmA_Relaxin_R	467..752	CDD:320265	8/44 (18%)
		TM helix 1	468..494	CDD:320265	6/31 (19%)
		TM helix 2	502..527	CDD:320265	1/3 (33%)
		TM helix 3	547..577	CDD:320265
		TM helix 4	588..610	CDD:320265
		TM helix 5	638..667	CDD:320265
		TM helix 6	681..711	CDD:320265
		TM helix 7	720..745	CDD:320265
Igfals	NP_001351825.1	LRR	88..457	CDD:443914	102/376 (27%)
		leucine-rich repeat	92..110	CDD:275380	5/17 (29%)
		leucine-rich repeat	114..134	CDD:275380	8/19 (42%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	4/22 (18%)
		leucine-rich repeat	183..206	CDD:275380	0/22 (0%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		leucine-rich repeat	303..326	CDD:275380	4/23 (17%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..396	CDD:275380	8/20 (40%)
		leucine-rich repeat	423..446	CDD:275380	4/28 (14%)
		LRR_8	445..505	CDD:404697	13/55 (24%)
		leucine-rich repeat	447..470	CDD:275380	6/22 (27%)
		leucine-rich repeat	471..494	CDD:275380	4/22 (18%)
		leucine-rich repeat	495..516	CDD:275380	2/5 (40%)
		leucine-rich repeat	519..542	CDD:275380
		LRR_8	521..571	CDD:404697
		leucine-rich repeat	543..561	CDD:275380
		LRRCT	570..613	CDD:214507