DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr4 and LRFN5

DIOPT Version :9

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_001333102.1 Gene:LRFN5 / 145581 HGNCID:20360 Length:719 Species:Homo sapiens


Alignment Length:272 Identity:78/272 - (28%)
Similarity:110/272 - (40%) Gaps:35/272 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   265 LILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFP 329
            |.||.|.:.::||.||.|:..|.:|.|..|.|.......||.|.||..|:||.|.|.::..|.| 
Human    56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMF- 119

  Fly   330 RTLLNLHTLSLAYNQIEDIAANTFP--FPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRI 392
            ..|.|||.|.|..||:..|::..|.  | .|..|.|:.|.|..|..:....:.:|..|.|:.|.|
Human   120 SGLSNLHHLILNNNQLTLISSTAFDDVF-ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI 183

  Fly   393 EGFDLEAFACLKNLSSLLLTGNRFQTLDSRVL----KNLTSLDYIYFSWFHLCSAAMNVRVCDPH 453
            :......|:.|..::.|.:|.|:.|.|....|    :.|.:...|..|.|.|...          
Human   184 DNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFG---------- 238

  Fly   454 GDGISSKLHLLDNQILRGSVWVMA-----SIAVVGNLLVLLGRYFY---KSRSNVEHSLYLRHLA 510
            |:.:.....||         |:..     .:....:..:|.||||:   :.....|..|..||..
Human   239 GNPLHCNCELL---------WLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTH 294

  Fly   511 ASDFLMGIYLTL 522
            ....|.|...||
Human   295 EMRVLEGQRATL 306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:278486
LRR_RI <184..397 CDD:238064 48/133 (36%)
LRR_8 188..248 CDD:290566
leucine-rich repeat 188..211 CDD:275380
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 238..261 CDD:275380
LRR_8 261..320 CDD:290566 23/54 (43%)
leucine-rich repeat 262..285 CDD:275380 9/19 (47%)
LRR_4 284..325 CDD:289563 15/40 (38%)
leucine-rich repeat 286..309 CDD:275380 8/22 (36%)
LRR_4 308..348 CDD:289563 17/39 (44%)
leucine-rich repeat 310..334 CDD:275380 9/23 (39%)
leucine-rich repeat 335..357 CDD:275380 9/23 (39%)
LRR_8 356..416 CDD:290566 16/59 (27%)
leucine-rich repeat 358..381 CDD:275380 6/22 (27%)
LRR_4 381..421 CDD:289563 12/39 (31%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
leucine-rich repeat 406..427 CDD:275380 6/24 (25%)
7tm_1 483..741 CDD:278431 13/43 (30%)
LRFN5NP_001333102.1 LRR 1 52..73 8/16 (50%)
LRR 2 76..97 6/20 (30%)
LRR 3 100..121 9/21 (43%)
LRR 4 124..145 9/20 (45%)
LRR 5 148..169 6/20 (30%)
LRR 6 172..193 6/20 (30%)
LRR 7 196..217 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..414
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..694
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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