DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and Fshr

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_038551.3	Gene:	Fshr / 14309	MGIID:	95583	Length:	692	Species:	Mus musculus

Alignment Length:	712	Identity:	156/712 - (21%)
Similarity:	274/712 - (38%)	Gaps:	173/712 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 CPCRGDEILCRFQQLTDIPERLPQH-----------------------DLATLDLTGNN-FETIH 202
            |.|.....||:..::|:||..||::                       ||..::::.|: .|.|.
Mouse    23 CHCSNRVFLCQDSKVTEIPPDLPRNAIELRFVLTKLRVIPKGSFSGFGDLEKIEISQNDVLEVIE 87

  Fly   203 ETFFSELPDVDSL-VLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILI 266
            ...||.||::..: :.|..::..|...||..|..  ||.|.:.:..:.|||.....:..|..:|.
Mouse    88 ADVFSNLPNLHEIRIEKANNLLYINPEAFQNLPS--LRYLLISNTGIKHLPAFHKIQSLQKVLLD 150

  Fly   267 LARN-HLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPR 330
            :..| ::|.:.|:.|:.|              :||:         .:|:||:|.::.:....|..
Mouse   151 IQDNINIHIIARNSFMGL--------------SFES---------VILWLNKNGIQEIHNCAFNG 192

  Fly   331 TLLNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGF 395
            |  .|..|:|:.|                      |.|..:.|:.|...|....|.::..::...
Mouse   193 T--QLDELNLSDN----------------------NNLEELPDDVFQGASGPVVLDISRTKVYSL 233

  Fly   396 DLEAFACLKNL---SSLLLTGNRFQTLDSRVLKNLTSLDY-----IYFSW--------------- 437
            .......||.|   |:..|  .:..:||..|:....||.|     .:.:|
Mouse   234 PNHGLENLKKLRARSTYRL--KKLPSLDKFVMLIEASLTYPSHCCAFANWRRQTSELHPICNKSI 296

  Fly   438 -------------------------------------FHLCSAAMNVRVCDPHGDGISSKLHLLD 465
                                                 :.||:..::| .|.|..|..:....::.
Mouse   297 SRQDIDDMTQPGDQRVSLVDDEPSYGKGSDMLYSEFDYDLCNEFVDV-TCSPKPDAFNPCEDIMG 360

  Fly   466 NQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISF 530
            ..|||..:|.::.:|:.||..||:.....:.:..|...| :.:||.:|..:||||.|||..||..
Mouse   361 YNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFL-MCNLAFADLCIGIYLLLIASVDIHT 424

  Fly   531 RGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLL 595
            :.:|..|...|:....|..|||.:.|:.:.|...|..:|.:|..::|..::.....::.....::
Mouse   425 KSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLAAITLERWHTITHAMQLECKVQLCHAASIM 489

  Fly   596 LL-WGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILF 659
            :| |..:|..|..|:     ||...|....:||.:.|..|.:   :...:..:::|.|:.:.|..
Mouse   490 VLGWAFAFAAALFPI-----FGISSYMKVSICLPMDIDSPLS---QLYVMALLVLNALAFVVICG 546

  Fly   660 SYIRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPIIV--------VKLAALSGCE 716
            .|..:...:|:.    ....|.|:..:|.|.|.::.||..|..||:.        |.|..:|..:
Mouse   547 CYTHIYLTVRNP----NIVSSSRDTKIAKRMATLIFTDFLCMAPILFFAISASLKVPLITVSKAK 607

  Fly   717 ISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQ----LRRY-CHTLPSCSLVNNETRSQT 773
            |       |.||..|:||..||.||.:.|..|::.    :.:: |:.: ...:...||.|.|
Mouse   608 I-------LLVLFYPINSCANPFLYAIFTKNFRRDFFVLMSKFGCYEV-QAQIYKTETSSIT 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	46/238 (19%)
		LRR_8	188..248	CDD:290566	16/61 (26%)
		leucine-rich repeat	188..211	CDD:275380	7/23 (30%)
		leucine-rich repeat	212..235	CDD:275380	5/23 (22%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	13/59 (22%)
		leucine-rich repeat	262..285	CDD:275380	6/23 (26%)
		LRR_4	284..325	CDD:289563	6/40 (15%)
		leucine-rich repeat	286..309	CDD:275380	2/22 (9%)
		LRR_4	308..348	CDD:289563	10/39 (26%)
		leucine-rich repeat	310..334	CDD:275380	6/23 (26%)
		leucine-rich repeat	335..357	CDD:275380	4/21 (19%)
		LRR_8	356..416	CDD:290566	11/62 (18%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		LRR_4	381..421	CDD:289563	7/42 (17%)
		leucine-rich repeat	382..405	CDD:275380	2/22 (9%)
		leucine-rich repeat	406..427	CDD:275380	6/23 (26%)
		7tm_1	483..741	CDD:278431	70/266 (26%)
Fshr	NP_038551.3	LRRNT	17..45	CDD:279764	7/21 (33%)
		leucine-rich repeat	48..71	CDD:275380	0/22 (0%)
		LRR 1	49..72		0/22 (0%)
		LRR_8	72..132	CDD:290566	16/61 (26%)
		leucine-rich repeat	72..96	CDD:275380	7/23 (30%)
		LRR 2	73..97		7/23 (30%)
		leucine-rich repeat	97..121	CDD:275380	5/23 (22%)
		LRR 3	98..118		4/19 (21%)
		LRR 4	119..143		7/25 (28%)
		leucine-rich repeat	122..143	CDD:275380	6/20 (30%)
		leucine-rich repeat	144..172	CDD:275380	8/41 (20%)
		LRR 5	144..169		7/38 (18%)
		LRR 6	170..192		7/30 (23%)
		leucine-rich repeat	173..194	CDD:275380	6/22 (27%)
		LRR_8	193..245	CDD:290566	13/75 (17%)
		LRR 7	193..216		9/46 (20%)
		leucine-rich repeat	195..219	CDD:275380	8/45 (18%)
		LRR 8	217..240		2/22 (9%)
		leucine-rich repeat	220..243	CDD:275380	2/22 (9%)
		LRR 9	241..259		5/19 (26%)
		GnHR_trans	282..348	CDD:289164	4/66 (6%)
		7tm_1	378..625	CDD:278431	70/266 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810