DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and Lgr5

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_034325.2	Gene:	Lgr5 / 14160	MGIID:	1341817	Length:	907	Species:	Mus musculus

Alignment Length:	926	Identity:	210/926 - (22%)
Similarity:	317/926 - (34%)	Gaps:	282/926 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VREVISLLGIID----GAESDILVPDADDK-CPGGYFHCNTTAQCVPQRANCDG----SVDCDDA 118
            |..::|||.::.    |:...   |||..: ||.   ||:         ...||    .|||.|.
Mouse     6 VHMLLSLLALLQLVAAGSSPG---PDAIPRGCPS---HCH---------CELDGRMLLRVDCSDL 55

  Fly   119 S-DEVNCVNEVDAKYWDHLYRKQPFGRHDNLRIGECLWPNENFSCP-------CRGDEILCRFQQ 175
            . .|:.....|...|.|                   |..|.....|       |..:|:......
Mouse    56 GLSELPSNLSVFTSYLD-------------------LSMNNISQLPASLLHRLCFLEELRLAGNA 101

  Fly   176 LTDIPER--LPQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPL 238
            ||.||:.  ...|.|..|.|..|....:.|.....|..:.||.|....|..:....|..|  :.|
Mouse   102 LTHIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGL--HSL 164

  Fly   239 RTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEV 303
            |.|::|||.|..:|...|...:.|..:.||.|.:||:....|.||..|..|.|..|||.:...:.
Mouse   165 RHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADYAFGNLSSLVVLHLHNNRIHSLGKKC 229

  Fly   304 FARLPNLEVLYLNENHLKRLDPDRFP---RTLLNLHTLSLAYNQIEDIAANTF------------ 353
            |..|.:||.|.||.|:|     |.||   :||.||..|....|.|..|....|
Mouse   230 FDGLHSLETLDLNYNNL-----DEFPTAIKTLSNLKELGFHSNNIRSIPERAFVGNPSLITIHFY 289

  Fly   354 -------------PFPRLRYLFLAG---------------------------------------- 365
                         ..|.||.|.|.|
Mouse   290 DNPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTATLESLTLTGAKISSLPQAVCDQLPNL 354

  Fly   366 -----------------------------NRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFA 401
                                         |.:..|:..||..|.||:.|:|..|:|......||:
Mouse   355 QVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGSTFQQLFNLRSLNLAWNKIAIIHPNAFS 419

  Fly   402 CLKNL------SSLL---------------LTGNR------------------------------ 415
            .|.:|      |:||               |||||
Mouse   420 TLPSLIKLDLSSNLLSSFPVTGLHGLTHLKLTGNRALQSLIPSANFPELKIIEMPSAYQCCAFGG 484

  Fly   416 -----------------------------FQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCD 451
                                         ||..|.|.|::.. ||      |.....|::...|.
Mouse   485 CENVYKISNQWNKDDGNSVDDLHKKDAGLFQVQDERDLEDFL-LD------FEEDLKALHSVQCS 542

  Fly   452 PHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRY---FYKSRSNVEHSLYLRHLAASD 513
            |.........||..:.::|..||..|.:|:..|.||.|..:   .|.|    ...|.:..:|..|
Mouse   543 PSPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALVALTVFRTPLYIS----SIKLLIGVIAVVD 603

  Fly   514 FLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTR 578
            .|||:...::|..|....|.:.::...|.....|...||||.|:.:||..||||...:|..||..
Mouse   604 ILMGVSSAVLAAVDAFTFGRFAQHGAWWEDGIGCQIVGFLSIFASESSIFLLTLAALERGFSVKC 668

  Fly   579 PLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSA 643
            ..| .:.:.....||.::|..:...|..|.:   |..|...|..:.:||.|...:|...|:   .
Mouse   669 SSK-FEVKAPLFSLRAIVLLCVLLALTIATI---PLLGGSKYNASPLCLPLPFGEPSTTGY---M 726

  Fly   644 LLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENV----VATRFAIIVTTDCACWLPI 704
            :..:|:|:|..:.:..:|.::..::..  |.:       ||:    :....|:::..:|..:.|:
Mouse   727 VALVLLNSLCFLIMTIAYTKLYCSLEK--GEL-------ENLWDCSMVKHIALLLFANCILYCPV 782

  Fly   705 IVVKLAALSGCE-ISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPSCSLVNNE 768
            ..:..::|.... ||||:..::.::::|:.|.|||:||.:....||:.:          ..:...
Mouse   783 AFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDM----------GSLGKH 837

  Fly   769 TRSQTQTAYESGLSVS 784
            ||...::.:.|.||::
Mouse   838 TRFWMRSKHASLLSIN 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	11/42 (26%)
		LRR_RI	<184..397	CDD:238064	75/309 (24%)
		LRR_8	188..248	CDD:290566	18/59 (31%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	9/22 (41%)
		LRR_8	261..320	CDD:290566	23/58 (40%)
		leucine-rich repeat	262..285	CDD:275380	9/22 (41%)
		LRR_4	284..325	CDD:289563	15/40 (38%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		LRR_4	308..348	CDD:289563	17/42 (40%)
		leucine-rich repeat	310..334	CDD:275380	12/26 (46%)
		leucine-rich repeat	335..357	CDD:275380	6/46 (13%)
		LRR_8	356..416	CDD:290566	29/208 (14%)
		leucine-rich repeat	358..381	CDD:275380	10/91 (11%)
		LRR_4	381..421	CDD:289563	20/119 (17%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..427	CDD:275380	14/100 (14%)
		7tm_1	483..741	CDD:278431	65/265 (25%)
Lgr5	NP_034325.2	LRRNT	33..70	CDD:214470	12/48 (25%)
		leucine-rich repeat	68..91	CDD:275380	5/41 (12%)
		LRR_RI	88..386	CDD:238064	71/304 (23%)
		LRR_8	92..150	CDD:290566	15/57 (26%)
		leucine-rich repeat	92..115	CDD:275380	5/22 (23%)
		leucine-rich repeat	116..139	CDD:275380	6/22 (27%)
		LRR_8	138..198	CDD:290566	19/61 (31%)
		leucine-rich repeat	140..163	CDD:275380	6/24 (25%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		LRR_8	188..246	CDD:290566	23/57 (40%)
		leucine-rich repeat	188..211	CDD:275380	9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..258	CDD:275380	12/26 (46%)
		LRR_8	257..314	CDD:290566	12/56 (21%)
		leucine-rich repeat	259..282	CDD:275380	6/22 (27%)
		leucine-rich repeat	283..304	CDD:275380	0/20 (0%)
		LRR_8	352..410	CDD:290566	10/57 (18%)
		leucine-rich repeat	354..375	CDD:275378	0/20 (0%)
		leucine-rich repeat	376..389	CDD:275378	1/12 (8%)
		leucine-rich repeat	400..423	CDD:275378	8/22 (36%)
		leucine-rich repeat	445..467	CDD:275378	5/21 (24%)
		7tm_1	575..820	CDD:278431	65/264 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810