DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and Rxfp2

DIOPT Version :10

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:XP_011239323.1 Gene:Rxfp2 / 140498 MGIID:2153463 Length:740 Species:Mus musculus


Alignment Length:694 Identity:238/694 - (34%)
Similarity:349/694 - (50%) Gaps:34/694 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 AESDILVPDADDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEVDAKYWDHLYRKQ 140
            |:|.::.|    .||.|||.|....:|:|:..:|||..||.:.:||.||   .|...|..:    
Mouse    22 ADSSMVAP----LCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNC---GDTSGWTTI---- 75

  Fly   141 PFGR-HDNLR----IGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFET 200
             ||. |.|:.    ..||........|.||.:|:.|....|..:|:  ...::..|.|..|....
Mouse    76 -FGTVHGNVNKVTLTQECFLSQYPQHCYCRENELECVKADLKAVPK--VSSNVTLLSLKKNKIHR 137

  Fly   201 IHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSIL 265
            :....||...::..:.|:...|..|:..||  |..:.|:.||:..|.:..|....|.:.:||:.|
Mouse   138 LPVKVFSRYTELRKIYLQHNCITHISRRAF--LGLHNLQILYLSHNCITSLRPGIFKDLHQLAWL 200

  Fly   266 ILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPR 330
            ||..|.:..:.:..|:.|..|..|.:.|||:......:.|::|.|..:.|..|.:|.:....| .
Mouse   201 ILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALPETLCAQMPQLNWVDLANNGIKYITNSTF-L 264

  Fly   331 TLLNLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEG 394
            |..:|..|.|..|||..:...|| ....|..|.|:.|.::.:....|.:|..||.|:|:.|.:..
Mouse   265 TCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNMITKLPVHLFSDLHLLQKLNLSSNPLLY 329

  Fly   395 FDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISS 459
            .....|..||.|.||.|.......:.:.:.:.:.:|.:||...|..||...:||:|.|..|||||
Mouse   330 VHKNQFGSLKQLQSLDLERIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISS 394

  Fly   460 KLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIA 524
            ...||.|.|||.||||:|.|..|||.||:..|...|: .|..|::.::.|..:|.|||:||..:.
Mouse   395 SEDLLANGILRVSVWVIAFITCVGNFLVIAVRSLIKA-ENTTHAMSIKILCCADCLMGVYLFSVG 458

  Fly   525 CADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVR 589
            ..||.:||:|.||...|..|..|...|||:|.|.:.|.||||.:|.::.:.:..|.......|.:
Mouse   459 VFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQ 523

  Fly   590 IVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLH---IHDPYAKGWEYSALLFILVNT 651
            ..:.|..:|.:.|.:||.|.....||| :|||.||||..||   ..|..::|  ||..:|:.||.
Mouse   524 TAVALASIWVVGFLIAAVPFTREDYFG-NFYGKNGVCFPLHYDQAEDFGSRG--YSLGIFLGVNL 585

  Fly   652 LSLIFILFSYIRMLQAIRDSG---GGMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALS 713
            |:.:.|:.||:.|..:|..:.   ..:|| |.|:|..||.||..||.:|..||:|:.|||:.:|.
Mouse   586 LAFLVIVISYVTMFCSIHKTALQTAEVRS-HIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLL 649

  Fly   714 GCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCH 757
            ..||...:.:|:.|..|||||||||:||||||:.||.:|::..|
Mouse   650 QVEIPGTITSWIVVFFLPVNSALNPILYTLTTSFFKDKLKQLLH 693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011 15/36 (42%)
LRR 167..>430 CDD:443914 68/263 (26%)
leucine-rich repeat 188..211 CDD:275380 5/22 (23%)
leucine-rich repeat 212..235 CDD:275380 6/22 (27%)
leucine-rich repeat 238..261 CDD:275380 6/22 (27%)
leucine-rich repeat 262..285 CDD:275380 7/22 (32%)
leucine-rich repeat 286..309 CDD:275380 6/22 (27%)
leucine-rich repeat 310..334 CDD:275380 6/23 (26%)
leucine-rich repeat 335..357 CDD:275380 8/22 (36%)
leucine-rich repeat 358..381 CDD:275380 6/22 (27%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
leucine-rich repeat 406..427 CDD:275380 4/20 (20%)
7tmA_Relaxin_R 467..752 CDD:320265 119/290 (41%)
TM helix 1 468..494 CDD:320265 15/25 (60%)
TM helix 2 502..527 CDD:320265 8/24 (33%)
TM helix 3 547..577 CDD:320265 12/29 (41%)
TM helix 4 588..610 CDD:320265 6/21 (29%)
TM helix 5 638..667 CDD:320265 11/28 (39%)
TM helix 6 681..711 CDD:320265 15/29 (52%)
TM helix 7 720..745 CDD:320265 15/24 (63%)
Rxfp2XP_011239323.1 LDLa 31..66 CDD:238060 15/34 (44%)
LRR <123..>350 CDD:443914 64/229 (28%)
leucine-rich repeat 125..148 CDD:275380 5/22 (23%)
leucine-rich repeat 149..172 CDD:275380 6/24 (25%)
leucine-rich repeat 173..196 CDD:275380 6/22 (27%)
leucine-rich repeat 197..220 CDD:275380 7/22 (32%)
leucine-rich repeat 221..244 CDD:275380 6/22 (27%)
leucine-rich repeat 245..268 CDD:275380 6/23 (26%)
leucine-rich repeat 269..292 CDD:275380 8/22 (36%)
leucine-rich repeat 293..316 CDD:275380 6/22 (27%)
leucine-rich repeat 317..340 CDD:275380 7/22 (32%)
leucine-rich repeat 341..360 CDD:275380 4/18 (22%)
7tm_GPCRs 403..688 CDD:475119 119/289 (41%)
TM helix 1 404..428 CDD:410628 14/23 (61%)
TM helix 2 437..458 CDD:410628 7/20 (35%)
TM helix 3 482..504 CDD:410628 10/21 (48%)
TM helix 4 526..542 CDD:410628 5/15 (33%)
TM helix 5 574..597 CDD:410628 10/24 (42%)
TM helix 6 623..645 CDD:410628 11/21 (52%)
TM helix 7 656..681 CDD:410628 15/24 (63%)

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