DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and RXFP2

DIOPT Version :9

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_570718.1 Gene:RXFP2 / 122042 HGNCID:17318 Length:754 Species:Homo sapiens


Alignment Length:758 Identity:248/758 - (32%)
Similarity:374/758 - (49%) Gaps:50/758 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 ISLLGIIDGA--ESDILVPDADDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEVD 129
            |.|:.:.|.|  :..::.|    .|..|||.|....:|:|:..:|||..||.:.:||.||   .|
Human    25 IVLINVKDFALTQGSMITP----SCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENC---GD 82

  Fly   130 AKYWDHLYRKQPFGR-HDNLR----IGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLA 189
            ...|..:     ||. |.|..    ..||........|.|:..|:.|....|..:|  :..:::.
Human    83 TSGWATI-----FGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVP--MISNNVT 140

  Fly   190 TLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEH 254
            .|.|..|...::.:..|.:...:..:.|:...||.|:..||..|.:  |:.||::.|.:..|...
Human   141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCN--LQILYLNHNCITTLRPG 203

  Fly   255 FFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENH 319
            .|.:.:||:.|||..|.:..:.:..|..|..|..|.:..|.:.....::.|::|.|..:.|..|.
Human   204 IFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNR 268

  Fly   320 LKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNLQ 383
            :|.|....| .:..:|..|.|..|||..:...|| ....|..|.|:.|.::.:....|.:|..||
Human   269 IKYLTNSTF-LSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQ 332

  Fly   384 GLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVR 448
            .|:|:.|.:.......|..||.|.||.|.......:::|:.:.:.:|.:|||..|..||.|.:||
Human   333 KLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVR 397

  Fly   449 VCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASD 513
            :|.|..|||||...||.|.|||..|||:|.|...|||.|:..|.|.|: .|..|::.::.|..:|
Human   398 ICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKA-ENTTHAMSIKILCCAD 461

  Fly   514 FLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTR 578
            .|||:||..:...||.:||:|.||...|..|..|...|||:..|.:.|.||||.:|.::.:.:..
Human   462 CLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVF 526

  Fly   579 P---LKP--RDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLH---IHDPY 635
            |   ::|  |.|..:     |:.:|...|.:|..|.....||| :|||.||||..|:   ..|..
Human   527 PFSNIRPGKRQTSVI-----LICIWMAGFLIAVIPFWNKDYFG-NFYGKNGVCFPLYYDQTEDIG 585

  Fly   636 AKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTH----SGRENVVATRFAIIVTT 696
            :||  ||..:|:.||.|:.:.|:||||.|..:|:.:  .:::|.    .|||..||.||..||.:
Human   586 SKG--YSLGIFLGVNLLAFLIIVFSYITMFCSIQKT--ALQTTEVRNCFGREVAVANRFFFIVFS 646

  Fly   697 DCACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPS 761
            |..||:|:.|||:.:|...||...:.:|:.:..|||||||||:||||||..||.:|::..|....
Human   647 DAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQR 711

  Fly   762 CSL--VNNETRSQTQTAYESGLSVSLAHLGGGVGGGSGRKRMS 802
            .|:  :..::.|.:....|...|:.|..|.....|.|..|.:|
Human   712 KSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:278486 14/36 (39%)
LRR_RI <184..397 CDD:238064 55/213 (26%)
LRR_8 188..248 CDD:290566 15/59 (25%)
leucine-rich repeat 188..211 CDD:275380 4/22 (18%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 238..261 CDD:275380 6/22 (27%)
LRR_8 261..320 CDD:290566 16/58 (28%)
leucine-rich repeat 262..285 CDD:275380 7/22 (32%)
LRR_4 284..325 CDD:289563 10/40 (25%)
leucine-rich repeat 286..309 CDD:275380 4/22 (18%)
LRR_4 308..348 CDD:289563 13/39 (33%)
leucine-rich repeat 310..334 CDD:275380 6/23 (26%)
leucine-rich repeat 335..357 CDD:275380 8/22 (36%)
LRR_8 356..416 CDD:290566 18/59 (31%)
leucine-rich repeat 358..381 CDD:275380 6/22 (27%)
LRR_4 381..421 CDD:289563 12/39 (31%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
leucine-rich repeat 406..427 CDD:275380 5/20 (25%)
7tm_1 483..741 CDD:278431 102/269 (38%)
RXFP2NP_570718.1 LDLa 45..80 CDD:238060 14/34 (41%)
LRR 1 138..159 4/20 (20%)
leucine-rich repeat 139..162 CDD:275380 4/22 (18%)
LRR_RI <155..303 CDD:238064 41/150 (27%)
LRR_8 161..221 CDD:290566 19/61 (31%)
LRR 2 162..183 6/20 (30%)
leucine-rich repeat 163..186 CDD:275380 7/22 (32%)
LRR 3 186..207 6/22 (27%)
leucine-rich repeat 187..210 CDD:275380 6/22 (27%)
LRR 4 210..231 7/20 (35%)
leucine-rich repeat 211..234 CDD:275380 7/22 (32%)
LRR 5 234..255 3/20 (15%)
leucine-rich repeat 235..258 CDD:275380 4/22 (18%)
LRR 6 258..279 6/21 (29%)
leucine-rich repeat 259..282 CDD:275380 6/23 (26%)
LRR_8 282..341 CDD:290566 19/58 (33%)
LRR 7 282..303 8/20 (40%)
leucine-rich repeat 283..306 CDD:275380 8/22 (36%)
LRR_4 305..>341 CDD:289563 11/35 (31%)
LRR 8 306..327 5/20 (25%)
leucine-rich repeat 307..330 CDD:275380 6/22 (27%)
LRR 9 330..351 6/20 (30%)
LRR_8 331..383 CDD:290566 14/51 (27%)
leucine-rich repeat 331..354 CDD:275380 7/22 (32%)
LRR 10 354..375 5/20 (25%)
leucine-rich repeat 355..374 CDD:275380 5/18 (28%)
7tm_4 424..>628 CDD:304433 76/214 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D256258at33208
OrthoFinder 1 1.000 - - FOG0002061
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101648
Panther 1 1.100 - - O PTHR24372
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1524
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.780

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