DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and RXFP2

DIOPT Version :10

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_570718.1 Gene:RXFP2 / 122042 HGNCID:17318 Length:754 Species:Homo sapiens


Alignment Length:758 Identity:248/758 - (32%)
Similarity:374/758 - (49%) Gaps:50/758 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 ISLLGIIDGA--ESDILVPDADDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEVD 129
            |.|:.:.|.|  :..::.|    .|..|||.|....:|:|:..:|||..||.:.:||.||   .|
Human    25 IVLINVKDFALTQGSMITP----SCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENC---GD 82

  Fly   130 AKYWDHLYRKQPFGR-HDNLR----IGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLA 189
            ...|..:     ||. |.|..    ..||........|.|:..|:.|....|..:|  :..:::.
Human    83 TSGWATI-----FGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVP--MISNNVT 140

  Fly   190 TLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEH 254
            .|.|..|...::.:..|.:...:..:.|:...||.|:..||..|.:  |:.||::.|.:..|...
Human   141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCN--LQILYLNHNCITTLRPG 203

  Fly   255 FFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENH 319
            .|.:.:||:.|||..|.:..:.:..|..|..|..|.:..|.:.....::.|::|.|..:.|..|.
Human   204 IFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNR 268

  Fly   320 LKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNLQ 383
            :|.|....| .:..:|..|.|..|||..:...|| ....|..|.|:.|.::.:....|.:|..||
Human   269 IKYLTNSTF-LSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQ 332

  Fly   384 GLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVR 448
            .|:|:.|.:.......|..||.|.||.|.......:::|:.:.:.:|.:|||..|..||.|.:||
Human   333 KLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVR 397

  Fly   449 VCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASD 513
            :|.|..|||||...||.|.|||..|||:|.|...|||.|:..|.|.|: .|..|::.::.|..:|
Human   398 ICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKA-ENTTHAMSIKILCCAD 461

  Fly   514 FLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTR 578
            .|||:||..:...||.:||:|.||...|..|..|...|||:..|.:.|.||||.:|.::.:.:..
Human   462 CLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVF 526

  Fly   579 P---LKP--RDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLH---IHDPY 635
            |   ::|  |.|..:     |:.:|...|.:|..|.....||| :|||.||||..|:   ..|..
Human   527 PFSNIRPGKRQTSVI-----LICIWMAGFLIAVIPFWNKDYFG-NFYGKNGVCFPLYYDQTEDIG 585

  Fly   636 AKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTH----SGRENVVATRFAIIVTT 696
            :||  ||..:|:.||.|:.:.|:||||.|..:|:.:  .:::|.    .|||..||.||..||.:
Human   586 SKG--YSLGIFLGVNLLAFLIIVFSYITMFCSIQKT--ALQTTEVRNCFGREVAVANRFFFIVFS 646

  Fly   697 DCACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPS 761
            |..||:|:.|||:.:|...||...:.:|:.:..|||||||||:||||||..||.:|::..|....
Human   647 DAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQR 711

  Fly   762 CSL--VNNETRSQTQTAYESGLSVSLAHLGGGVGGGSGRKRMS 802
            .|:  :..::.|.:....|...|:.|..|.....|.|..|.:|
Human   712 KSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011 14/36 (39%)
LRR 167..>430 CDD:443914 67/263 (25%)
leucine-rich repeat 188..211 CDD:275380 4/22 (18%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 238..261 CDD:275380 6/22 (27%)
leucine-rich repeat 262..285 CDD:275380 7/22 (32%)
leucine-rich repeat 286..309 CDD:275380 4/22 (18%)
leucine-rich repeat 310..334 CDD:275380 6/23 (26%)
leucine-rich repeat 335..357 CDD:275380 8/22 (36%)
leucine-rich repeat 358..381 CDD:275380 6/22 (27%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
leucine-rich repeat 406..427 CDD:275380 5/20 (25%)
7tmA_Relaxin_R 467..752 CDD:320265 118/296 (40%)
TM helix 1 468..494 CDD:320265 13/25 (52%)
TM helix 2 502..527 CDD:320265 8/24 (33%)
TM helix 3 547..577 CDD:320265 11/29 (38%)
TM helix 4 588..610 CDD:320265 5/21 (24%)
TM helix 5 638..667 CDD:320265 13/28 (46%)
TM helix 6 681..711 CDD:320265 16/29 (55%)
TM helix 7 720..745 CDD:320265 14/24 (58%)
RXFP2NP_570718.1 LDLa 45..80 CDD:238060 14/34 (41%)
LRR <128..370 CDD:443914 64/246 (26%)
LRR 1 138..159 4/20 (20%)
leucine-rich repeat 139..162 CDD:275380 4/22 (18%)
LRR 2 162..183 6/20 (30%)
leucine-rich repeat 163..186 CDD:275380 7/22 (32%)
LRR 3 186..207 6/22 (27%)
leucine-rich repeat 187..210 CDD:275380 6/22 (27%)
LRR 4 210..231 7/20 (35%)
leucine-rich repeat 211..234 CDD:275380 7/22 (32%)
LRR 5 234..255 3/20 (15%)
leucine-rich repeat 235..258 CDD:275380 4/22 (18%)
LRR 6 258..279 6/21 (29%)
leucine-rich repeat 259..282 CDD:275380 6/23 (26%)
LRR 7 282..303 8/20 (40%)
leucine-rich repeat 283..306 CDD:275380 8/22 (36%)
LRR 8 306..327 5/20 (25%)
leucine-rich repeat 307..330 CDD:275380 6/22 (27%)
LRR 9 330..351 6/20 (30%)
leucine-rich repeat 331..354 CDD:275380 7/22 (32%)
LRR 10 354..375 5/20 (25%)
leucine-rich repeat 355..374 CDD:275380 5/18 (28%)
7tmA_RXFP2_LGR8 416..702 CDD:320632 118/296 (40%)
TM helix 1 417..443 CDD:320632 13/25 (52%)
TM helix 2 450..475 CDD:320632 8/24 (33%)
TM helix 3 495..525 CDD:320632 11/29 (38%)
TM helix 4 536..558 CDD:320632 7/26 (27%)
TM helix 5 586..615 CDD:320632 14/30 (47%)
TM helix 6 631..661 CDD:320632 16/29 (55%)
TM helix 7 670..695 CDD:320632 14/24 (58%)

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