DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr4 and rxfp1

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001177863.1	Gene:	rxfp1 / 100498669	ZFINID:	ZDB-GENE-110125-1	Length:	748	Species:	Danio rerio

Alignment Length:	672	Identity:	221/672 - (32%)
Similarity:	338/672 - (50%)	Gaps:	21/672 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 CPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEVDAKYWDHLYRKQPFGRHDNLRIGE- 152
            ||.|||.|...:.|:||..:|:|..||.:.:||.||   .|...|.||:... ||...| .:|.
Zfish    29 CPLGYFPCGNLSTCLPQVLHCNGVDDCGNQADEENC---GDNNGWPHLFDNY-FGIPSN-NLGNK 88

  Fly   153 ---CLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDS 214
               ||.......|.||..|:.|......|:|  :...::..:.|..|....::...|.:...:..
Zfish    89 SDACLLGTVPAECQCRDLELDCDGAHFKDVP--MVSINVTMMSLQRNGLRKLNADMFLKYQSLQK 151

  Fly   215 LVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSD 279
            |.|:...|:.:...||..|.:  |..||:..|::..|....|.:.::|..|||..|.|||:....
Zfish   152 LYLQHNRIKSVHPQAFRGLYN--LTRLYLSYNRITTLLPDVFQDLHKLEWLILENNSLHHISSLT 214

  Fly   280 FLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQ 344
            |..|:.|..|.|..|.:...: ::...:|.|..|.:..|.::.:....| |:...|..|.|..|:
Zfish   215 FSGLRSLVLLVLLNNALTKLD-DICLEMPRLNWLDIEGNKMETVGNVTF-RSCNMLTVLVLQRNR 277

  Fly   345 IEDIAANTFPFPR-LRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSS 408
            |..|.|..|...| |..|.|:.||:..|..:.|.||.:|..|:::.|.|....::.|..|..|.|
Zfish   278 ISRIHAQAFSLLRKLGELDLSSNRIEAIPPDLFVNLGDLLQLNISYNPIMNLRVDHFDKLHKLKS 342

  Fly   409 LLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSV 473
            |.:.|.....:..|:.:.|.:|.:|||..|..|..|..||.|.|:.|||||...||.|.:||..|
Zfish   343 LSIEGIEIGNIHRRMFEPLKNLTHIYFKKFQYCGYAPYVRSCKPNTDGISSFEDLLANIVLRVFV 407

  Fly   474 WVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYE 538
            |.:::....||:.|:..|.:.:|.:.: |::.:..|..:|.|||:||.:|...|:.|||||.::.
Zfish   408 WAVSATTCFGNIFVICMRSYIRSENKL-HAMCIISLCCADGLMGVYLFMIGAYDLKFRGEYNRHA 471

  Fly   539 ETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLLWGISFG 603
            :....|..|...|.|:..|.:.|.||||.:|.::.:.:..|.:.....:.|.|..|:::|.:.|.
Zfish   472 QAGMDSEACQVIGSLAMLSTEVSVLLLTYLTLEKYICIVYPFRYLTLGRRRTVTILVVIWVLGFI 536

  Fly   604 LAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWE-YSALLFILVNTLSLIFILFSYIRMLQA 667
            :|..|||....| .:|||.||||..||...|...|.: ||.::|:.:|.::.:.|:.||..|...
Zfish   537 IAFLPLLFKGVF-RNFYGTNGVCFPLHSEQPETLGAQIYSIVIFLGLNLVAFLIIVLSYGSMFYN 600

  Fly   668 IRDSGGGMR--STHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALSGCEISPDLYAWLAVLVL 730
            |:.:|....  |.|..:|..:|.||..||.||..||:||.::|..:|...||...:.:|:.:.:|
Zfish   601 IQRTGTQTTKYSNHIKKELTIAKRFFSIVITDSLCWIPIFILKTLSLMEVEIPGTISSWVVIFIL 665

  Fly   731 PVNSALNPVLYTLTTAAFKQQL 752
            |:||||||:||||||..||:.|
Zfish   666 PINSALNPILYTLTTRPFKETL 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	15/34 (44%)
		LRR_RI	<184..397	CDD:238064	57/213 (27%)
		LRR_8	188..248	CDD:290566	13/59 (22%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	18/58 (31%)
		leucine-rich repeat	262..285	CDD:275380	10/22 (45%)
		LRR_4	284..325	CDD:289563	8/40 (20%)
		leucine-rich repeat	286..309	CDD:275380	4/22 (18%)
		LRR_4	308..348	CDD:289563	11/39 (28%)
		leucine-rich repeat	310..334	CDD:275380	5/23 (22%)
		leucine-rich repeat	335..357	CDD:275380	8/21 (38%)
		LRR_8	356..416	CDD:290566	20/60 (33%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		LRR_4	381..421	CDD:289563	10/39 (26%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..427	CDD:275380	5/20 (25%)
		7tm_1	483..741	CDD:278431	90/260 (35%)
rxfp1	NP_001177863.1	LDLa	29..64	CDD:238060	15/34 (44%)
		LRR_RI	99..304	CDD:238064	56/210 (27%)
		leucine-rich repeat	125..148	CDD:275380	3/22 (14%)
		LRR_8	148..207	CDD:290566	17/60 (28%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	196..278	CDD:290566	24/83 (29%)
		leucine-rich repeat	197..220	CDD:275380	10/22 (45%)
		leucine-rich repeat	221..243	CDD:275380	4/22 (18%)
		leucine-rich repeat	244..267	CDD:275380	5/23 (22%)
		LRR_8	268..326	CDD:290566	21/57 (37%)
		leucine-rich repeat	268..291	CDD:275380	8/22 (36%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		leucine-rich repeat	316..339	CDD:275380	6/22 (27%)
		leucine-rich repeat	340..361	CDD:275380	5/20 (25%)
		7tm_1	417..676	CDD:278431	90/260 (35%)
		7tm_4	<482..>616	CDD:304433	43/134 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11007
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920