DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr4 and rxfp1

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_031751332.1	Gene:	rxfp1 / 100494807	XenbaseID:	XB-GENE-985695	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	704	Identity:	220/704 - (31%)
Similarity:	340/704 - (48%)	Gaps:	70/704 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNC------VNEVDAKYWDHLYRKQPFGR 144
            |..||.|||.|....:|:||..:|:|..:|.:.:||.||      ..::|..:..| |.|.....
Frog    26 DISCPLGYFPCGNITKCLPQFMHCNGVDECGNQADEDNCGDNNGWSQQLDKLFEKH-YEKIGLNV 89

  Fly   145 HD-NLRIGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSE 208
            .| .::..||........|.|||.|:.|...:|..:|...|  ::..:.|..|....:....|..
Frog    90 FDLEMKPSECTLGPVPTQCLCRGLELDCDGAKLRTVPSVSP--NVTIMSLQNNMLRKLGPDEFRI 152

  Fly   209 LPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLH 273
            .||:..|.|:..:||.::.|||        :.||                  .|:.|.|:.|.:.
Frog   153 FPDLRKLYLQHNNIRTVSVHAF--------KGLY------------------NLTKLYLSHNEIT 191

  Fly   274 HLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTL 338
            .||...|.:|.:|:.|.:..|:|.....:.|..|.:|.:|.:..|.|:||......:.:..|:.|
Frog   192 TLKPGVFEDLHRLEWLIIENNKITRIYPQTFQGLNSLILLVMMNNFLERLPDKSLCQHMPKLNWL 256

  Fly   339 SLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFAC 402
            ....|.::.:...|| ....|..|.:..||:|.|.:.||.:|..|..|.|..||||.|.......
Frog   257 DFEGNNVQSLTNTTFISCATLTVLVMRRNRISTISENTFSSLYRLDELDLANNRIEAFSPSLMKG 321

  Fly   403 LKNLSSLLLTGNRFQTLDS------------------------RVLKNLTSLDYIYFSWFHLCSA 443
            :|.||.|.::.|..|.:.:                        |:...|.:|.:|||..|..|..
Frog   322 VKELSQLNISHNPIQKIQADQFDYVIKLKSLSLEGIEIPNIQRRMFMPLKNLTHIYFKKFQYCGF 386

  Fly   444 AMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRH 508
            |.:||.|.|:.|||||..:||.:.:.|..|||::.|...||:.|:..|.:.:|.:.: |::.:..
Frog   387 APHVRNCKPNTDGISSLENLLASIVQRVFVWVVSVITCFGNIFVICTRPYIRSENKL-HAMSIMS 450

  Fly   509 LAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRL 573
            |..:|.|||:||.:|...|:.:||||.:..:.|..|..|...|.|:..|.:.|.||||.:|.::.
Frog   451 LCCADCLMGVYLFVIGYFDLKYRGEYNENAQAWMDSTQCRLVGSLAILSTEVSVLLLTYLTLEKY 515

  Fly   574 MSVTRPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKG 638
            :.:..|.:.....|.|.:..|:|:|.|.|.:|..| |.|..|..::||.||||..||...|.:..
Frog   516 ICIVYPFRCLKPGKCRTITTLILIWIIGFVIAFIP-LSNQTFFHNYYGTNGVCFPLHSEQPESTA 579

  Fly   639 WE-YSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRST----HSGRENVVATRFAIIVTTDC 698
            .: ||.::|:.||..:.|.|:|||..|..:|..:  .:.:|    |..:|..:|.||..||.||.
Frog   580 AQIYSVIIFLGVNLAAFIIIVFSYSSMFYSIHRT--AIMATEIHNHIKKEMTLAKRFFFIVFTDA 642

  Fly   699 ACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQL 752
            .||:||.::||.:|...||...:.:|:.:.:||:||||||:|||:||..||:.:
Frog   643 LCWIPIFILKLLSLLQVEIPGSISSWVVIFILPINSALNPILYTITTRPFKEMI 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	14/36 (39%)
		LRR_RI	<184..397	CDD:238064	57/213 (27%)
		LRR_8	188..248	CDD:290566	14/59 (24%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	238..261	CDD:275380	2/22 (9%)
		LRR_8	261..320	CDD:290566	17/58 (29%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		LRR_4	284..325	CDD:289563	12/40 (30%)
		leucine-rich repeat	286..309	CDD:275380	6/22 (27%)
		LRR_4	308..348	CDD:289563	9/39 (23%)
		leucine-rich repeat	310..334	CDD:275380	6/23 (26%)
		leucine-rich repeat	335..357	CDD:275380	5/22 (23%)
		LRR_8	356..416	CDD:290566	22/59 (37%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		LRR_4	381..421	CDD:289563	14/39 (36%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..427	CDD:275380	6/44 (14%)
		7tm_1	483..741	CDD:278431	93/262 (35%)
rxfp1	XP_031751332.1	LDLa	29..64	CDD:238060	14/34 (41%)
		LRRNT	105..134	CDD:214470	9/30 (30%)
		PPP1R42	131..375	CDD:411060	65/269 (24%)
		leucine-rich repeat	132..155	CDD:275380	3/22 (14%)
		leucine-rich repeat	156..179	CDD:275380	9/48 (19%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	228..252	CDD:275380	6/23 (26%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		leucine-rich repeat	349..370	CDD:275380	1/20 (5%)
		7tmA_RXFP1_LGR7	410..696	CDD:320631	105/289 (36%)
		TM helix 1	412..436	CDD:320631	9/23 (39%)
		TM helix 2	445..466	CDD:320631	7/20 (35%)
		TM helix 3	490..512	CDD:320631	8/21 (38%)
		TM helix 4	534..550	CDD:320631	6/15 (40%)
		TM helix 5	582..605	CDD:320631	10/22 (45%)
		TM helix 6	631..653	CDD:320631	11/21 (52%)
		TM helix 7	664..689	CDD:320631	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11007
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020