DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr4 and LOC100494508

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_002938964.2	Gene:	LOC100494508 / 100494508	-ID:	-	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	708	Identity:	224/708 - (31%)
Similarity:	353/708 - (49%)	Gaps:	40/708 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 VISLLGIIDGAESDILVPDADDK--CPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEV 128
            ::||..::..|...:::|...|.  ||.|.|.|...:.|:||..:|:|..||.:.:||.||   |
Frog     4 LLSLAPLLLSATESLMIPSNLDSGICPLGQFPCGNLSVCLPQLLHCNGHKDCANGADEENC---V 65

  Fly   129 DAKYWDHLY----------RKQPFGRHDNLRIGECLWPNENFSCPCRGDEILCRFQQLTDIPERL 183
            |...|..|:          :.|....|      ||:.......|.|....:.|..|.|..:|.
Frog    66 DNSGWPKLFDTIQSARGNRKMQDEETH------ECMLDIYPEPCECWRRMVNCSSQGLHSVPP-- 122

  Fly   184 PQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKL 248
            ...::..|:|..|..:|:|:..||...|::.|:|:...:.:|:..||..|.  .|:.|::..|::
Frog   123 VSSNVTALNLKDNKIKTLHDGIFSRYQDLEKLLLQNNELHDISRLAFSGLF--KLKMLFLSQNRI 185

  Fly   249 PHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNF-EAEVFARLPNLEV 312
            ..|....|.:...|..|||..|.:..:....|..|:.|..||:..|.|... ...:...:|:|..
Frog   186 RSLKAGVFKDLRSLEWLILDNNQVSKIVPGTFSGLESLYFLDMLNNSIREIPRNSICEEMPHLNW 250

  Fly   313 LYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETF 376
            |.|..|.::.:....|...:.   .|||..|.|..|..... ...:|..|.|:.|::..:....|
Frog   251 LDLEGNQMQTIHSSVFQECIT---VLSLRRNNIRKIRKGALSQMNKLVDLDLSMNQIVELSPSLF 312

  Fly   377 CNLSNLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLC 441
            .||.:||.|:::.|.::......|..|.||.||.:.......:.:|:..:|.:|.:|||..|..|
Frog   313 TNLRDLQQLNISFNPLQHIQPNQFDLLSNLQSLNMEDIEIPNIHNRMFSSLVNLSHIYFKKFQYC 377

  Fly   442 SAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYL 506
            |.|.:||.|.|:.|||||..:||.|.:||..|||||.:...|||.|:..|.|..: .|.:|::.:
Frog   378 SYAPHVRSCKPNSDGISSFENLLANILLRVFVWVMACVTCFGNLFVICMRSFIVT-ENCQHTMSI 441

  Fly   507 RHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWD 571
            :.|..:|.|||.||..:...||.|:|||.|:.:.|..|..|...|.|:..|.:.|.::||.:|.:
Frog   442 KSLCCADCLMGFYLFCLGAFDIKFQGEYNKHAQAWMESWECKLVGSLAMLSSEVSVMMLTYMTLE 506

  Fly   572 RLMSVTRPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIH--DP 634
            :.:.:..|.......:.:.:..|..:||:.|.:...|......|| :|||.||||..|...  :.
Frog   507 KYLCIVFPFSHFRAGRGQTLCTLTAIWGLGFFITVIPFFSYDTFG-NFYGRNGVCFPLQSDSTEK 570

  Fly   635 Y-AKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGG--GMRSTHSGRENVVATRFAIIVTT 696
            | |:|  ||..:|:.:|.|:.:.|:|||..|..:|..:|.  ..||..| ||..:|.||..||.|
Frog   571 YGARG--YSVSIFLGLNLLAFVTIVFSYSSMFYSIHKTGAKTAERSVLS-REVTIAKRFFFIVFT 632

  Fly   697 DCACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRR 754
            |..||:||.::|..:|:..||...:.:|:.:.:||:||||||:||||||::|:::|::
Frog   633 DALCWIPIFLLKAVSLTEAEIPGTITSWIVIFILPINSALNPILYTLTTSSFQEKLKQ 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	15/38 (39%)
		LRR_RI	<184..397	CDD:238064	54/214 (25%)
		LRR_8	188..248	CDD:290566	17/59 (29%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	5/22 (23%)
		LRR_8	261..320	CDD:290566	17/59 (29%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		LRR_4	284..325	CDD:289563	10/41 (24%)
		leucine-rich repeat	286..309	CDD:275380	5/23 (22%)
		LRR_4	308..348	CDD:289563	11/39 (28%)
		leucine-rich repeat	310..334	CDD:275380	5/23 (22%)
		leucine-rich repeat	335..357	CDD:275380	6/22 (27%)
		LRR_8	356..416	CDD:290566	17/59 (29%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		LRR_4	381..421	CDD:289563	10/39 (26%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..427	CDD:275380	4/20 (20%)
		7tm_1	483..741	CDD:278431	92/262 (35%)
LOC100494508	XP_002938964.2	LDLa	29..64	CDD:238060	14/34 (41%)
		leucine-rich repeat	108..126	CDD:275378	4/19 (21%)
		internalin_A	125..>369	CDD:380193	63/248 (25%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		leucine-rich repeat	151..174	CDD:275380	6/24 (25%)
		leucine-rich repeat	175..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		leucine-rich repeat	223..247	CDD:275380	5/23 (22%)
		leucine-rich repeat	248..269	CDD:275380	5/20 (25%)
		leucine-rich repeat	271..293	CDD:275380	6/24 (25%)
		leucine-rich repeat	294..317	CDD:275380	7/22 (32%)
		leucine-rich repeat	318..341	CDD:275380	6/22 (27%)
		leucine-rich repeat	342..363	CDD:275380	4/20 (20%)
		7tm_GPCRs	403..688	CDD:391938	106/289 (37%)
		TM helix 1	405..429	CDD:341315	12/23 (52%)
		TM helix 2	438..459	CDD:341315	7/20 (35%)
		TM helix 3	483..505	CDD:341315	6/21 (29%)
		TM helix 4	527..543	CDD:341315	4/15 (27%)
		TM helix 5	575..598	CDD:341315	10/24 (42%)
		TM helix 6	620..645	CDD:341315	11/24 (46%)
		TM helix 7	656..681	CDD:341315	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020