DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr4 and rxfp2

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_012813666.2	Gene:	rxfp2 / 100491657	XenbaseID:	XB-GENE-1011464	Length:	723	Species:	Xenopus tropicalis

Alignment Length:	706	Identity:	228/706 - (32%)
Similarity:	357/706 - (50%)	Gaps:	28/706 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEVDAKYWDHLYRKQPFGRHDNLRI 150
            |.:|..|:|.|.....|:|:..:|||..||::.:||..|   .|...|.:::.:.....:|.:..
Frog     9 DPECRMGFFPCGNVTICLPRTFHCDGVKDCENGADEEYC---GDNSGWANIFYEVHGKTNDVIEP 70

  Fly   151 GECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSL 215
            .||.......||.|:..|:.|....|..:|  ....::..|.|..|....:.:..|....|:..|
Frog    71 QECCLSRFPESCECKDTELECVDVNLEAVP--YVSSNVTLLSLKRNKIHALPDEVFIGYHDLTKL 133

  Fly   216 VLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDF 280
            .|:...::.|:..||..|..  |:.||:.:|.:.:|.:..|....:|..|||..|.:..:.:..|
Frog   134 FLQHNCLKNISQKAFFGLYH--LQRLYLSNNCISYLQQGIFSHLRELKWLILDENPIIRISQDIF 196

  Fly   281 LNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQI 345
            ..|..|..|.:..|.:......:.|::|.:..:....|.:|.|:...|. |...|..|.|..|||
Frog   197 AGLTSLFFLSMINNSLEALPQRLCAQMPLINWMDFEGNRIKTLESSSFV-TCNELTVLFLRGNQI 260

  Fly   346 EDIAANTFPFPR-LRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSL 409
            ..:..|.|...| |..:.|:.|.::.:...:|..|.:||.|:|..|.:..: .|.|..|::|.||
Frog   261 SLVKENIFSSLRSLAEIDLSNNLITRVPLSSFKELKHLQKLNLGCNPLSLY-TEQFESLQHLQSL 324

  Fly   410 LLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVW 474
            .|.......:.:|:.:.:.:|.:|||..|..||.|.:||||.|..|||||..:||.|.|||..||
Frog   325 DLEKIEIPNISTRMFQPMKNLSHIYFKKFRYCSYAPHVRVCTPLTDGISSFENLLANTILRVFVW 389

  Fly   475 VMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEE 539
            |:|.|...||:.|:..|...:| .|..|::.::.|..:|.||||||..|...|:.:||:|.||..
Frog   390 VIACITCFGNIFVIGMRSCIQS-ENKTHTMSIKVLCCADCLMGIYLFFIGVFDVKYRGQYKKYAL 453

  Fly   540 TWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLLWGISFGL 604
            .|..|..|...|||:..|.:.|.||||.:|.::.:::..|.......|.:.::.|:.||.:.|.:
Frog   454 LWMESLQCRSLGFLAMLSTEVSVLLLTFLTLEKYLAIVFPFSNIRPGKRQTLIILISLWAVGFII 518

  Fly   605 AAAPLLPNPYFGSHFYGNNGVCLSLH-IHDPYAKGWEYSALLFILVNTLSLIFILFSYIRMLQAI 668
            |..|.....:|| ::||.||||..|: .....|.|..||..:|:.||.|:.|.|:||||.|..:|
Frog   519 AIVPFWNEDFFG-NYYGKNGVCFPLYPDQTEEAGGQGYSLGVFLGVNLLAFIIIVFSYISMFCSI 582

  Fly   669 RDSGGGMR----STHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALSGCEISPDLYAWLAVLV 729
            :.:  .:|    ::|...:..||.||..||.:|..||:|:.::|:.:|...||...:.:|:.:.:
Frog   583 QKT--ALRTSEVNSHIHTDVAVANRFFFIVFSDAVCWIPVFLLKILSLFRVEIPGTVTSWIVIFI 645

  Fly   730 LPVNSALNPVLYTLTTAAFKQQLRRYCHTLPSCSLVNNETRSQTQTAYESGLSVSL 785
            ||:||||||:||||||:.||::|::..|.....|:..||.:|         ||.||
Frog   646 LPINSALNPILYTLTTSFFKEKLKQLLHRQRRRSVFRNERKS---------LSTSL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	13/36 (36%)
		LRR_RI	<184..397	CDD:238064	53/213 (25%)
		LRR_8	188..248	CDD:290566	15/59 (25%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	13/58 (22%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		LRR_4	284..325	CDD:289563	8/40 (20%)
		leucine-rich repeat	286..309	CDD:275380	4/22 (18%)
		LRR_4	308..348	CDD:289563	12/39 (31%)
		leucine-rich repeat	310..334	CDD:275380	5/23 (22%)
		leucine-rich repeat	335..357	CDD:275380	8/21 (38%)
		LRR_8	356..416	CDD:290566	18/60 (30%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		LRR_4	381..421	CDD:289563	12/39 (31%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..427	CDD:275380	5/20 (25%)
		7tm_1	483..741	CDD:278431	93/262 (35%)
rxfp2	XP_012813666.2	LDLa	12..47	CDD:238060	13/34 (38%)
		PPP1R42	105..347	CDD:411060	62/245 (25%)
		leucine-rich repeat	106..129	CDD:275380	4/22 (18%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..177	CDD:275380	6/22 (27%)
		leucine-rich repeat	178..201	CDD:275380	7/22 (32%)
		leucine-rich repeat	202..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..249	CDD:275380	5/23 (22%)
		leucine-rich repeat	250..273	CDD:275380	8/22 (36%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		leucine-rich repeat	298..320	CDD:275380	8/22 (36%)
		leucine-rich repeat	321..340	CDD:275380	5/18 (28%)
		7tmA_RXFP2_LGR8	382..668	CDD:320632	109/289 (38%)
		TM helix 1	384..408	CDD:320632	11/23 (48%)
		TM helix 2	417..438	CDD:320632	8/20 (40%)
		TM helix 3	462..484	CDD:320632	9/21 (43%)
		TM helix 4	506..522	CDD:320632	5/15 (33%)
		TM helix 5	554..577	CDD:320632	11/22 (50%)
		TM helix 6	603..625	CDD:320632	9/21 (43%)
		TM helix 7	636..661	CDD:320632	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110