Protein Alignment Lgr4 and igfals

DIOPT Version :10

• Sequence 1: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: XP_002940278.2
• Gene: igfals / 100489984
• XenbaseID: XB-GENE-1008441
• Length: 601
• Species: Xenopus tropicalis
• Alignment Length: 534
• Identity: 129/534 - (24%)
• Similarity: 207/534 - (38%)
• Gaps: 140/534 - (26%)

  Fly   162 CPCRGD-----EILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVL---K 218
            |.|..|     .:.|..:.||.:||. |.....:|.|.|||..|:....|..|..:|.|.|   :
 Frog    39 CVCSYDYSEEYSVFCSSRNLTRVPEP-PPPAARSLWLDGNNLTTVQAGAFRNLSHLDFLNLQSSQ 102

  Fly   219 FCSIREIASHAFDRLAD-----NPLRTL----------------------YMDD----------- 245
            ..|:.:.|.|....||.     |.:::|                      .::|
 Frog   103 VASLEQQALHGLKALAHLHLERNMIKSLAPSTFTHTQNLVSLTLNNNFLTKIEDGLFSGLSNLWY 167

  Fly   246 -----NKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFA 305
                 |.|..||:..|.:...|..|:||.|.|.:|:.|.||:|.:|:||||.||.:...:|.||.
 Frog   168 LNLGWNLLVVLPDMVFHDLLNLRELVLAGNRLVYLQPSLFLSLGELKELDLSGNSLKGIKANVFT 232

  Fly   306 RLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANT-FPFPRLRYLFLAGNRLS 369
            |......||||.||:..:.|..| ..:.||..|.|::|::..:..:| |..|.|..|.|:.|.|:
 Frog   233 RQQKTHKLYLNHNHISTVAPRAF-SGMKNLRWLDLSHNRLTALYEDTFFGLPSLNVLRLSNNSLT 296

  Fly   370 HIR------------------------DETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSLL 410
            .:|                        :.||..|:.|:.|.||.|.::.....:|..|.|::.:.
 Frog   297 SLRPRIFKDLQFLVELNLGQNKIKILLERTFEGLAQLELLSLNHNNVQEIRPGSFLGLLNVAVIN 361

  Fly   411 LTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISS--KLHLLDNQI----- 468
            |:||..::|.....|.|..|..:     |:.|:.:: .:......|:||  :|.|.:|:|
 Frog   362 LSGNCLKSLAEHCFKGLGKLHSL-----HMESSCLS-HIKPQMFAGLSSIRRLFLQNNEIVAIED 420

  Fly   469 -----LRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSL------------------YLRHLA 510
                 |.|    :..:.:..|.|..|....:....|:.:.|                  .|:.|.
 Frog   421 HSFTDLHG----LLELDLRSNKLTHLTTRSFTGLKNLSYLLLSSNQILTISPEVFSPVQQLQWLD 481

  Fly   511 ASD-----FLMGIYLTLIACADISFRGEYIK------------YEETWRHSGV----CAFAGFLS 554
            .||     ....|:|.|.:...:|.:...:|            .::.|.:...    ||..| |.
 Frog   482 LSDNQLKALTEDIFLPLSSLRYLSLKNNCLKTISVNFLIPPPTMQQLWLNGNQWDCGCALKG-LR 545

  Fly   555 TFSCQSSTLLLTLV 568
            ..:.::||::..||
 Frog   546 DLALRNSTIVPHLV 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011
		LRR	167..>430	CDD:443914	92/338 (27%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	7/25 (28%)
		leucine-rich repeat	238..261	CDD:275380	7/60 (12%)
		leucine-rich repeat	262..285	CDD:275380	11/22 (50%)
		leucine-rich repeat	286..309	CDD:275380	11/22 (50%)
		leucine-rich repeat	310..334	CDD:275380	8/23 (35%)
		leucine-rich repeat	335..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	9/46 (20%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..427	CDD:275380	5/20 (25%)
		7tmA_Relaxin_R	467..752	CDD:320265	26/151 (17%)
		TM helix 1	468..494	CDD:320265	6/35 (17%)
		TM helix 2	502..527	CDD:320265	8/47 (17%)
		TM helix 3	547..577	CDD:320265	8/22 (36%)
		TM helix 4	588..610	CDD:320265
		TM helix 5	638..667	CDD:320265
		TM helix 6	681..711	CDD:320265
		TM helix 7	720..745	CDD:320265
igfals	XP_002940278.2	leucine-rich repeat	69..92	CDD:275380	8/22 (36%)
		PLN00113	71..>534	CDD:215061	112/473 (24%)
		leucine-rich repeat	93..116	CDD:275380	6/22 (27%)
		leucine-rich repeat	117..140	CDD:275380	4/22 (18%)
		leucine-rich repeat	141..164	CDD:275380	1/22 (5%)
		leucine-rich repeat	165..188	CDD:275380	5/22 (23%)
		leucine-rich repeat	189..212	CDD:275380	11/22 (50%)
		leucine-rich repeat	213..236	CDD:275380	11/22 (50%)
		leucine-rich repeat	237..260	CDD:275380	8/23 (35%)
		leucine-rich repeat	261..284	CDD:275380	6/22 (27%)
		leucine-rich repeat	285..308	CDD:275380	6/22 (27%)
		leucine-rich repeat	309..332	CDD:275380	3/22 (14%)
		leucine-rich repeat	333..354	CDD:275380	6/20 (30%)
		leucine-rich repeat	357..380	CDD:275380	6/22 (27%)
		leucine-rich repeat	381..404	CDD:275380	4/28 (14%)
		leucine-rich repeat	405..428	CDD:275380	5/22 (23%)
		leucine-rich repeat	429..450	CDD:275380	3/20 (15%)
		leucine-rich repeat	453..472	CDD:275380	1/18 (6%)
		leucine-rich repeat	477..500	CDD:275380	7/22 (32%)
		leucine-rich repeat	525..537	CDD:275378	1/11 (9%)