Protein Alignment Lgr4 and tmtops2b

DIOPT Version :10

• Sequence 1: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001269302.1
• Gene: tmtops2b / 100331536
• ZFINID: ZDB-GENE-110411-43
• Length: 368
• Species: Danio rerio
• Alignment Length: 296
• Identity: 79/296 - (26%)
• Similarity: 137/296 - (46%)
• Gaps: 37/296 - (12%)

  Fly   484 NLLVLLGRYFYKSRS-NVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVC 547
            ||:||:  .|.|.:: ....::.|.:::.||.|:.::.|.::.|. |.||.::    ..||.  |
Zfish    45 NLVVLV--LFCKFKTLRTPVNMLLLNISISDMLVCMFGTTLSFAS-SVRGRWL----LGRHG--C 100

  Fly   548 AFAGFLSTFSCQSSTLLLTLV--TWDRLMSVTRPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLL 610
            .:.||::  ||.....|::||  ::||..::|...| |..:..:.:|.:...|..|......|||
Zfish   101 MWYGFIN--SCFGIVSLISLVVLSYDRYSTLTVYHK-RAPDYRKPLLAVGGSWLYSLIWTVPPLL 162

  Fly   611 PNPYFGSHFYGNNGVCLSLHIH--DPYAKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGG 673
                 |...||..|...|..:.  ...|:...|...||:....|.::.:::.|.|:|.|::.. |
Zfish   163 -----GWSSYGLEGAGTSCSVSWTQRTAESHAYIICLFVFCLGLPVLVMVYCYGRLLYAVKQV-G 221

  Fly   674 GMRSTHSGRENVVATRFAIIVTTDC--ACWLPIIVVKLAALSGCE--ISPDLYAWLAVLVLPVNS 734
            .:|.| :.|:......|.:|.|..|  .||:|..||.:.|..|..  ||| :.:.:..|:...::
Zfish   222 KIRKT-AARKREYHVLFMVITTVVCYLLCWMPYGVVAMMATFGRPGIISP-VASVVPSLLAKSST 284

  Fly   735 ALNPVLYTLTTAAFKQQLRRYCHTLPSC---SLVNN 767
            .:||::|.|....|.:     |..:..|   ||:.|
Zfish   285 VINPLIYILMNKQFYR-----CFRILFCCQRSLLQN 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011
		LRR	167..>430	CDD:443914
		leucine-rich repeat	188..211	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	238..261	CDD:275380
		leucine-rich repeat	262..285	CDD:275380
		leucine-rich repeat	286..309	CDD:275380
		leucine-rich repeat	310..334	CDD:275380
		leucine-rich repeat	335..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..427	CDD:275380
		7tmA_Relaxin_R	467..752	CDD:320265	74/276 (27%)
		TM helix 1	468..494	CDD:320265	4/9 (44%)
		TM helix 2	502..527	CDD:320265	5/24 (21%)
		TM helix 3	547..577	CDD:320265	10/31 (32%)
		TM helix 4	588..610	CDD:320265	4/21 (19%)
		TM helix 5	638..667	CDD:320265	7/28 (25%)
		TM helix 6	681..711	CDD:320265	10/31 (32%)
		TM helix 7	720..745	CDD:320265	5/24 (21%)
tmtops2b	NP_001269302.1	7tmA_tmt_opsin	28..302	CDD:320214	74/281 (26%)
		TM helix 1	29..55	CDD:320214	5/11 (45%)
		TM helix 2	62..88	CDD:320214	6/26 (23%)
		TM helix 3	100..130	CDD:320214	10/31 (32%)
		TM helix 4	140..162	CDD:320214	4/21 (19%)
		TM helix 5	187..217	CDD:320214	7/29 (24%)
		TM helix 6	230..260	CDD:320214	9/29 (31%)
		TM helix 7	270..295	CDD:320214	6/25 (24%)