DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and LINGO1

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_116197.4	Gene:	LINGO1 / 84894	HGNCID:	21205	Length:	620	Species:	Homo sapiens

Alignment Length:	430	Identity:	129/430 - (30%)
Similarity:	190/430 - (44%)	Gaps:	62/430 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SRPWLCGAI------------PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRA-LCVDAAL 64
            |:..|.|.:            |:|||:|.:  :|....|. ||.:|:|   .|..|| ||.....
Human     4 SKRMLAGGVRSMPSPLLACWQPILLLVLGS--VLSGSATG-CPPRCEC---SAQDRAVLCHRKRF 62

  Fly    65 EDVPIQLNPETKYINLTVNRIRTL---EF-SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTL 125
            ..||..:..||:.::|..|||:||   || |.|   .||.|:|::||:..:....|.....||||
Human    63 VAVPEGIPTETRLLDLGKNRIKTLNQDEFASFP---HLEELELNENIVSAVEPGAFNNLFNLRTL 124

  Fly   126 NLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKG 190
            .|..|.:..:....|.||:||..||:|.|:|..:......||.:|..|::.:|::|.:....|.|
Human   125 GLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSG 189

  Fly   191 MNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSV-QGNVMSE 254
            :|:||.|......|..:|...|.|||.|..|.:....:..:|:.||:.|..|..|.: ....:..
Human   190 LNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDT 254

  Fly   255 LDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHL 319
            :..:...|| :|..|.::..|||.||...:..|..|.:|||..|..|.:.......|..|:|:.|
Human   255 MTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQL 318

  Fly   320 SRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-P 383
            .                          ..||:.:....|:|...:..:.:..|.|.||..:.| .
Human   319 V--------------------------GGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHS 357

  Fly   384 VDQLQKLYLGDNPLQCNCSLLWL----WRLVTGNFEGVDP 419
            |..|:.|.|..|||.|:|.|||:    |||   ||....|
Human   358 VGNLETLILDSNPLACDCRLLWVFRRRWRL---NFNRQQP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	11/25 (44%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	48/193 (25%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	10/47 (21%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	14/60 (23%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	13/37 (35%)
		LRR	<66..371	CDD:227223	96/334 (29%)
		LRR 1	72..93		10/20 (50%)
		leucine-rich repeat	73..96	CDD:275380	11/25 (44%)
		LRR 2	96..117		7/20 (35%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		LRR_8	120..179	CDD:338972	21/58 (36%)
		LRR 3	120..141		7/20 (35%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		LRR 4	144..165		7/20 (35%)
		leucine-rich repeat	145..192	CDD:275380	14/46 (30%)
		LRR 5	168..189		5/20 (25%)
		LRR 6	192..213		6/20 (30%)
		leucine-rich repeat	193..216	CDD:275380	8/22 (36%)
		LRR 7	216..237		5/20 (25%)
		leucine-rich repeat	217..264	CDD:275380	10/47 (21%)
		LRR 8	264..285		7/20 (35%)
		leucine-rich repeat	265..288	CDD:275380	8/22 (36%)
		LRR 9	288..309		6/20 (30%)
		leucine-rich repeat	289..312	CDD:275380	7/22 (32%)
		LRR 10	312..333		6/46 (13%)
		leucine-rich repeat	313..336	CDD:275380	7/48 (15%)
		LRR 11	336..357		5/20 (25%)
		leucine-rich repeat	337..357	CDD:275380	5/19 (26%)
		PCC	341..>421	CDD:188093	23/57 (40%)
		Ig	439..514	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BH3X
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8524
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.960