DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and RLP35

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001319521.1	Gene:	RLP35 / 820279	AraportID:	AT3G11080	Length:	943	Species:	Arabidopsis thaliana

Alignment Length:	905	Identity:	194/905 - (21%)
Similarity:	306/905 - (33%)	Gaps:	305/905 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYMK 97
            :.|..||....:...|...|.   ..|...:.|.:.:.|:....|.:...|.      ||.....
plant    71 VSPHPTTESWRNNSDCCNWEG---ITCDTKSGEVIELDLSCSWLYGSFHSNS------SLFRLQN 126

  Fly    98 LEILDLSQN-----IIETLGS-------------------KNFEYQSELRTLNLSRNLVS----- 133
            |.:|||:||     |..::|:                   .:.|..|.|.:|:||.|..|
plant   127 LRVLDLTQNDLDGEIPSSIGNLSHLTSLHLSYNQFLGLIPSSIENLSRLTSLHLSSNQFSGQIPS 191

  Fly   134 -----------SLHKHAFKG--------LTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNN 179
                       .|..:.|.|        |:||..|.|..|......|:::.:||.|..|.|:.||
plant   192 SIGNLSHLTSLELSSNQFSGQIPSSIGNLSNLTFLSLPSNDFFGQIPSSIGNLARLTYLYLSYNN 256

  Fly   180 IVSLEDNCFKGMNTLEVLVFRNNRLL-DVPAS--NLWHLHAL------------KSLDMSLNLVE 229
            .|....:.|..:|.|.||...:|:|. :||.|  ||..|.||            .::.:..||::
plant   257 FVGEIPSSFGNLNQLIVLQVDSNKLSGNVPISLLNLTRLSALLLSHNQFTGTIPNNISLLSNLMD 321

  Fly   230 F-VRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLT-MVPTQQLSKLSNLTY 292
            | ..|::|.|               .|..|.| .:..|..||||||.|. .:....:|..|||.|
plant   322 FEASNNAFTG---------------TLPSSLF-NIPPLIRLDLSDNQLNGTLHFGNISSPSNLQY 370

  Fly   293 LNLGGNRF-----SQLPAVAFLNLFHLREL-------------HLSRLDFLQRIDSRAFVDNTHL 339
            |.:|.|.|     ..|.....|.||.|..|             ||..||.|:    .:::..|
plant   371 LIIGSNNFIGTIPRSLSRFVNLTLFDLSHLNTQCRPVDFSIFSHLKSLDDLR----LSYLTTT-- 429

  Fly   340 QTLHLNN-NPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLG-----DNP-- 396
             |:.||: .|....:......||       :.|.:.::..|:..|...:|.|||.     |.|
plant   430 -TIDLNDILPYFKTLRSLDISGN-------LVSATNKSSVSSDPPSQSIQSLYLSGCGITDFPEI 486

  Fly   397 --LQCNCSLL-------------WLWRL-------VTGN----FEGVD----------PGMEHAA 425
              .|.....|             |||.|       ::.|    ||...          |.|.|
plant   487 LRTQHELGFLDVSNNKIKGQVPGWLWTLPNLFYLNLSNNTFISFESSSKKHGLSSVRKPSMIH-- 549

  Fly   426 GGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNS 490
                                 ..||.::....:.::|.....:|.|..:|          :|.|.
plant   550 ---------------------LFASNNNFTGKIPSFICGLRSLNTLDLSE----------NNYNG 583

  Fly   491 GILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEIT--CPAHIVTVVCAVITCLLVAMIGISVLYYL 553
            .|.|       |   .:|:::...:|.:.:..::  .|.||           ..::..:.|.:.|
plant   584 SIPR-------C---MEKLKSTLFVLNLRQNNLSGGLPKHI-----------FESLRSLDVGHNL 627

  Fly   554 RFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGLG--LGMSMTLGGGNHVNGLGMTLNYPH 616
            ...|..|.|:.     .::..::||....:....|..|.  ..:.:.:...|..:|       |.
plant   628 LVGKLPRSLIR-----FSNLEVLNVESNRINDTFPFWLSSLSKLQVLVLRSNAFHG-------PI 680

  Fly   617 HAQTLQ-------AHHHYHQAMP---------LQSHGGN---------GNHEYQQTTLPQLDK-- 654
            |..|..       :|:|::..:|         :.|.|.|         |:..|.|.::..::|
plant   681 HEATFPELRIIDISHNHFNGTLPTEYFVKWSAMSSLGKNEDQSNEKYMGSGLYYQDSMVLMNKGL 745

  Fly   655 -LELER----YLAAQTIANEYRALKPWELPVKEADDEPEHLYERFDHYEYPDTHTMSKLKQAASL 714
             :||.|    |.|.....|::..    |:|                       .::..||:...|
plant   746 AMELVRILTIYTALDFSGNKFEG----EIP-----------------------KSIGLLKELLVL 783

  Fly   715 NHSNSSAGPSPVPPSSGKPHVVY---VXRGRGTGERVSQINTDIEMVGLNHLHLHHHHHN 771
            |.||::.| ..:|.|.|....:.   |.:.:.||| :.|     |:..|:.|...:..||
plant   784 NLSNNAFG-GHIPSSMGNLTALESLDVSQNKLTGE-IPQ-----ELGDLSFLAYMNFSHN 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	9/46 (20%)
		LRR_8	120..180	CDD:404697	23/83 (28%)
		leucine-rich repeat	122..145	CDD:275380	10/46 (22%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR	<161..>354	CDD:227223	66/228 (29%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	11/25 (44%)
		leucine-rich repeat	218..265	CDD:275380	10/59 (17%)
		leucine-rich repeat	266..289	CDD:275380	9/23 (39%)
		leucine-rich repeat	290..313	CDD:275380	9/27 (33%)
		leucine-rich repeat	314..338	CDD:275380	7/36 (19%)
		LRR_8	337..397	CDD:404697	16/69 (23%)
		leucine-rich repeat	339..360	CDD:275380	4/21 (19%)
RLP35	NP_001319521.1	LRRNT_2	39..95	CDD:311940	5/26 (19%)
		PLN00113	79..>658	CDD:331614	146/676 (22%)
		leucine-rich repeat	103..123	CDD:275380	5/25 (20%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	1/22 (5%)
		leucine-rich repeat	175..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		leucine-rich repeat	223..246	CDD:275380	6/22 (27%)
		leucine-rich repeat	247..270	CDD:275380	7/22 (32%)
		leucine-rich repeat	271..294	CDD:275380	10/22 (45%)
		leucine-rich repeat	295..318	CDD:275380	3/22 (14%)
		leucine-rich repeat	319..337	CDD:275380	6/32 (19%)
		leucine-rich repeat	343..367	CDD:275380	9/23 (39%)
		leucine-rich repeat	368..388	CDD:275380	7/19 (37%)
		leucine-rich repeat	392..417	CDD:275380	7/24 (29%)
		leucine-rich repeat	443..469	CDD:275380	5/32 (16%)
		leucine-rich repeat	470..492	CDD:275380	7/21 (33%)
		leucine-rich repeat	493..516	CDD:275380	5/22 (23%)
		leucine-rich repeat	517..541	CDD:275380	3/23 (13%)
		leucine-rich repeat	542..570	CDD:275380	6/50 (12%)
		leucine-rich repeat	571..594	CDD:275380	9/42 (21%)
		leucine-rich repeat	596..617	CDD:275380	4/31 (13%)
		leucine-rich repeat	618..641	CDD:275380	5/27 (19%)
		LRR_8	640..698	CDD:316378	10/64 (16%)
		leucine-rich repeat	642..665	CDD:275380	4/22 (18%)
		leucine-rich repeat	716..803	CDD:275380	24/114 (21%)
		PLN00113	<758..864	CDD:331614	24/113 (21%)
		leucine-rich repeat	804..825	CDD:275380	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000