DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Lrrn3

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_110483.2	Gene:	Lrrn3 / 81514	RGDID:	71066	Length:	707	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	112/397 - (28%)
Similarity:	191/397 - (48%)	Gaps:	36/397 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IPVLLLLLLTLVILPPETTAFCPSKCQC-LGGEANSRAL--------CVDAALEDVPIQLNPETK 76
            |.|||.|.:|.::...:....||..|.| :......|::        |.|..|.:.|.:|..:|:
  Rat     8 IHVLLGLAITALVQAGDKKVDCPQLCTCEIRPWFTPRSIYMEALTVDCNDLGLLNFPARLPADTQ 72

  Fly    77 YINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFK 141
            .:.|..|.|..:|.|..|.:.|..||||||.:.::.:.|.:..|:|.::.|..|.::.|.:....
  Rat    73 ILLLQTNNIARIEHSTDFPVNLTGLDLSQNNLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLY 137

  Fly   142 GLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLD 206
            ||:||..|.::.|.:..:.|.|...|.:|:.|.|.:|.:..:....|:.:..||:|:..:|.:|.
  Rat   138 GLSNLQELYVNHNLLSAISPGAFVGLHNLLRLHLNSNRLQMINSKWFEALPNLEILMLGDNPILR 202

  Fly   207 VPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDL 271
            :...|                        |:.|.:|.:|.:.|..::|:...|..||.:|:.:..
  Rat   203 IKDMN------------------------FQPLLKLRSLVIAGINLTEVPGDALVGLENLESISF 243

  Fly   272 SDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDN 336
            .||.|..||...|.|..||.:|:|..|..:::....|.|:.||:||.::.:..|..|||.| |||
  Rat   244 YDNRLNKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELVSIDSLA-VDN 307

  Fly   337 -THLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQC 399
             ..|:.:...|||:||.|....|...|.:..:.:.||:|..||.... .:..|:::.:..||::|
  Rat   308 LPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRC 372

  Fly   400 NCSLLWL 406
            :|.:.|:
  Rat   373 DCVIRWI 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/21 (33%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	18/59 (31%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR	<161..>354	CDD:227223	56/193 (29%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	9/46 (20%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	11/24 (46%)
		LRR_8	337..397	CDD:404697	16/60 (27%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
Lrrn3	NP_110483.2	LRRNT	28..72	CDD:214470	10/43 (23%)
		LRR 1	70..91		6/20 (30%)
		LRR	<72..355	CDD:227223	89/307 (29%)
		leucine-rich repeat	72..93	CDD:275380	6/20 (30%)
		LRR 2	93..114		8/20 (40%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		LRR 3	117..138		4/20 (20%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		LRR 4	141..162		6/20 (30%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		LRR 5	165..186		5/20 (25%)
		leucine-rich repeat	166..189	CDD:275380	5/22 (23%)
		LRR 6	189..210		7/44 (16%)
		leucine-rich repeat	190..213	CDD:275380	8/46 (17%)
		LRR 7	213..234		5/20 (25%)
		leucine-rich repeat	214..237	CDD:275380	7/22 (32%)
		LRR 8	237..258		7/20 (35%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		LRR 9	261..282		6/20 (30%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		LRR 10	285..304		8/18 (44%)
		leucine-rich repeat	286..310	CDD:275380	11/24 (46%)
		LRR 11	310..332		8/21 (38%)
		leucine-rich repeat	311..333	CDD:275380	8/21 (38%)
		LRR 12	335..358		5/22 (23%)
		leucine-rich repeat	336..359	CDD:275378	5/22 (23%)
		PCC	341..>405	CDD:188093	11/39 (28%)
		leucine-rich repeat	360..372	CDD:275378	3/11 (27%)
		Ig	440..513	CDD:416386
		Ig strand B	440..447	CDD:409353
		Ig strand C	453..458	CDD:409353
		Ig strand C'	461..464	CDD:409353
		Ig strand D	470..474	CDD:409353
		Ig strand E	479..483	CDD:409353
		Ig strand F	493..500	CDD:409353
		Ig strand G	503..513	CDD:409353
		fn3	526..593	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8997
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010