DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fili and Flrt3

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001165631.1 Gene:Flrt3 / 71436 MGIID:1918686 Length:649 Species:Mus musculus


Alignment Length:409 Identity:97/409 - (23%)
Similarity:160/409 - (39%) Gaps:97/409 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT--LEFSLPFYMKLEILDLS 104
            |||.|:|..|    ...|.|.:|..:|:.:..:...:.|..|:|..  :...|...:|::.:.|.
Mouse    31 CPSVCRCDAG----FIYCNDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLY 91

  Fly   105 QNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLAS 169
            .|.::       |:.:.|      ...|..||              |..|.|.|:...:||.:..
Mouse    92 HNSLD-------EFPTNL------PKYVKELH--------------LQENNIRTITYDSLSKIPY 129

  Fly   170 LVELDLTNNNI--VSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVR 232
            |.||.|.:|::  ||:|:..|:..|.|.:|....|.|..:|..   ....::.|.:..|.:..:.
Mouse   130 LEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGG---LPRTIEELRLDDNRISTIS 191

  Fly   233 NDSFEGLKELLALSVQGNVMSELDL--SAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNL 295
            :.|..||..|..|.:.||:::...|  ..|..|::|..|.|..|:||..|            :||
Mouse   192 SPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP------------VNL 244

  Fly   296 GGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQG 360
            .|....:|         :|::.|::      |:...||.....|..|.::|| .||::|..:|. 
Mouse   245 PGTSLRKL---------YLQDNHIN------RVPPNAFSYLRQLYRLDMSNN-NLSNLPQGIFD- 292

  Fly   361 NPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWL--WRL---VTGNFEG-VDP 419
                                  .:|.:.:|.|.:||..|.|.:.|:  |..   |..|..| :..
Mouse   293 ----------------------DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQ 335

  Fly   420 GMEHAAGGAVAALAKEADD 438
            ..|...|.|:..|:.|..|
Mouse   336 APEKVRGMAIKDLSAELFD 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 4/23 (17%)
leucine-rich repeat 98..121 CDD:275380 3/22 (14%)
LRR_8 120..180 CDD:404697 15/59 (25%)
leucine-rich repeat 122..145 CDD:275380 4/22 (18%)
leucine-rich repeat 146..169 CDD:275380 6/22 (27%)
LRR <161..>354 CDD:227223 51/196 (26%)
leucine-rich repeat 170..193 CDD:275380 9/24 (38%)
leucine-rich repeat 194..217 CDD:275380 5/22 (23%)
leucine-rich repeat 218..265 CDD:275380 12/48 (25%)
leucine-rich repeat 266..289 CDD:275380 7/22 (32%)
leucine-rich repeat 290..313 CDD:275380 4/22 (18%)
leucine-rich repeat 314..338 CDD:275380 5/23 (22%)
LRR_8 337..397 CDD:404697 12/59 (20%)
leucine-rich repeat 339..360 CDD:275380 8/20 (40%)
Flrt3NP_001165631.1 LRRNT 31..61 CDD:214470 10/33 (30%)
Interaction with ADGRL3. /evidence=ECO:0000250|UniProtKB:Q9NZU0 38..67 6/32 (19%)
LRR 1. /evidence=ECO:0000255 58..82 4/23 (17%)
LRR_4 61..100 CDD:289563 8/45 (18%)
leucine-rich repeat 61..84 CDD:275378 4/22 (18%)
LRR 2. /evidence=ECO:0000255 83..105 5/34 (15%)
leucine-rich repeat 85..104 CDD:275380 4/31 (13%)
LRR_8 106..166 CDD:290566 22/73 (30%)
leucine-rich repeat 106..129 CDD:275380 9/36 (25%)
LRR_RI 107..327 CDD:238064 69/287 (24%)
LRR 3. /evidence=ECO:0000255 107..126 7/32 (22%)
LRR 4. /evidence=ECO:0000255 127..152 9/24 (38%)
leucine-rich repeat 130..155 CDD:275380 9/24 (38%)
LRR 5. /evidence=ECO:0000255 153..176 6/25 (24%)
leucine-rich repeat 156..176 CDD:275380 5/22 (23%)
LRR_8 175..237 CDD:290566 16/61 (26%)
leucine-rich repeat 177..200 CDD:275380 5/22 (23%)
LRR 6. /evidence=ECO:0000255 178..197 3/18 (17%)
LRR 7. /evidence=ECO:0000255 198..223 7/24 (29%)
leucine-rich repeat 201..226 CDD:275380 7/24 (29%)
LRR 8. /evidence=ECO:0000255 224..246 10/33 (30%)
leucine-rich repeat 227..248 CDD:275380 10/32 (31%)
LRR_8 247..306 CDD:290566 17/97 (18%)
LRR 9. /evidence=ECO:0000255 247..269 6/36 (17%)
leucine-rich repeat 249..272 CDD:275380 6/37 (16%)
LRR 10. /evidence=ECO:0000255 270..293 8/46 (17%)
leucine-rich repeat 273..296 CDD:275380 8/46 (17%)
LRRCT 305..356 CDD:214507 15/50 (30%)
fn3 413..478 CDD:278470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..649
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
10.960

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