DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Lrfn4

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001102978.1	Gene:	Lrfn4 / 688721	RGDID:	1585286	Length:	636	Species:	Rattus norvegicus

Alignment Length:	395	Identity:	101/395 - (25%)
Similarity:	129/395 - (32%)	Gaps:	156/395 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86
            |.||||||.      ...|.||..|.|.....:...||....|..||    |       .|:| |
  Rat     3 PPLLLLLLA------SGAAACPLPCVCQNLSESLSTLCAHRGLLFVP----P-------NVDR-R 49

  Fly    87 TLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDL 151
            |:|           |.|:.|.|:.||..:|...:.|..|.||||.::.:...:|
  Rat    50 TVE-----------LRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARSF----------- 92

  Fly   152 SFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLH 216
                         .||.||..|.|..|.:|.|..:..:|                 |. ||.|
  Rat    93 -------------GDLESLRSLHLDGNRLVELGSSSLRG-----------------PV-NLQH-- 124

  Fly   217 ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLI-SLKHLDLSDNNLTMVP 280
                                        |.:.||.:..:...||:..: ||:.||:|.|||..||
  Rat   125 ----------------------------LILSGNQLGRIAPGAFDDFLDSLEDLDVSYNNLRQVP 161

  Fly   281 TQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLN 345
            ...:..:..|..|||..|....||...|..|     ..|||||          :.:..|.||
  Rat   162 WAGIGSMPALHTLNLDHNLIDALPPGVFAQL-----SQLSRLD----------LTSNRLATL--- 208

  Fly   346 NNPQLSDIPMRLF------QGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLL 404
                   .|..||      :.:|:.|                       .|....|||.|||.||
  Rat   209 -------APDPLFSRGRDAEASPSPL-----------------------VLSFSGNPLHCNCELL 243

  Fly   405 WLWRL 409
            ||.||
  Rat   244 WLRRL 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/21 (24%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	14/59 (24%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	2/22 (9%)
		LRR	<161..>354	CDD:227223	46/193 (24%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	5/47 (11%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	10/65 (15%)
		leucine-rich repeat	339..360	CDD:275380	6/26 (23%)
Lrfn4	NP_001102978.1	LRR 1	49..70		10/31 (32%)
		leucine-rich repeat	50..73	CDD:275380	9/33 (27%)
		PPP1R42	53..203	CDD:411060	57/236 (24%)
		LRR 2	73..94		7/44 (16%)
		leucine-rich repeat	74..97	CDD:275380	9/46 (20%)
		LRR 3	97..118		7/20 (35%)
		leucine-rich repeat	98..121	CDD:275380	8/40 (20%)
		LRR 4	121..142		8/50 (16%)
		leucine-rich repeat	122..146	CDD:275380	7/53 (13%)
		LRR 5	146..169		10/22 (45%)
		leucine-rich repeat	147..170	CDD:275380	9/22 (41%)
		LRR 6	170..191		8/20 (40%)
		leucine-rich repeat	171..194	CDD:275380	9/27 (33%)
		LRR 7	194..215		10/40 (25%)
		leucine-rich repeat	195..213	CDD:275380	9/37 (24%)
		LRRCT	234..278	CDD:214507	12/15 (80%)
		Ig	281..368	CDD:416386
		Ig strand A	281..284	CDD:409353
		Ig strand A'	288..291	CDD:409353
		Ig strand B	297..305	CDD:409353
		Ig strand C	311..316	CDD:409353
		Ig strand C'	319..321	CDD:409353
		Ig strand D	327..331	CDD:409353
		Ig strand E	334..338	CDD:409353
		Ig strand F	348..355	CDD:409353
		Ig strand G	358..368	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..585
		PDZ-binding	633..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000