DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Vasn

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001102852.1	Gene:	Vasn / 679921	RGDID:	1598149	Length:	673	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	124/488 - (25%)
Similarity:	175/488 - (35%)	Gaps:	146/488 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRI 85
            :|.||||||.|:   ......|||.|||   .......|.......||..:.|:|..:.:..|.|
  Rat     7 LPPLLLLLLVLL---GSGVQSCPSGCQC---NQPQTVFCTARQGTTVPRDVPPDTVGLYIFENGI 65

  Fly    86 RTLEFS-LPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLL 149
            .||:.. ...:..|::||||||.|.:|....|:....|..|:|:.|.:..:....|:||..|..|
  Rat    66 TTLDVGCFAGFPGLQLLDLSQNQITSLPGGIFQPLVNLSNLDLTANKLHEISNETFRGLRRLERL 130

  Fly   150 DLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWH 214
            .|..|||..:.|.|...|..|:||.|.:|.:                      |:|. |.    |
  Rat   131 YLGKNRIRHIQPGAFDALDHLLELKLPDNEL----------------------RVLP-PL----H 168

  Fly   215 LHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMV 279
            |..|..||:|.|.:..:.....: ...:.||.:.|..:.:||...|..|.:|..||:|||.|..:
  Rat   169 LPRLLLLDLSHNSIPALEAGILD-TANVEALRLAGLGLRQLDEGLFGRLRNLHDLDVSDNQLGHM 232

  Fly   280 PTQQLSKLSNLTYLNLGGN-RFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLH 343
            |: .:..|..||.|.|.|| |.:|           :|...|:.|..||.:|    |.|..||.|.
  Rat   233 PS-VIQGLRGLTRLRLAGNTRIAQ-----------IRPEDLAGLTALQELD----VSNLSLQALP 281

  Fly   344 LNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWR 408
                   ||:                         |:.||  :|:.|....||..|.|.|.|
  Rat   282 -------SDL-------------------------SSLFP--RLRLLAAARNPFNCLCPLSW--- 309

  Fly   409 LVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALHT 473
                                                             ...::.|.|:|.|
  Rat   310 -------------------------------------------------FGPWVRESHVVLA--- 322

  Fly   474 TEPSAYELATSSSNRNSG--ILRMDRQQIGCDI 504
               |..|.......:|:|  :|.:|....||.:
  Rat   323 ---SPEETRCHFPPKNAGRLLLELDYADFGCPV 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/22 (23%)
		leucine-rich repeat	98..121	CDD:275380	10/22 (45%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	55/193 (28%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	8/23 (35%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	11/59 (19%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
Vasn	NP_001102852.1	LRRNT	25..55	CDD:214470	10/32 (31%)
		leucine-rich repeat	35..57	CDD:275380	5/21 (24%)
		PPP1R42	58..257	CDD:411060	69/238 (29%)
		leucine-rich repeat	58..78	CDD:275380	4/19 (21%)
		leucine-rich repeat	79..102	CDD:275380	10/22 (45%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		leucine-rich repeat	127..150	CDD:275380	9/22 (41%)
		leucine-rich repeat	151..194	CDD:275380	15/70 (21%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		leucine-rich repeat	219..241	CDD:275380	9/22 (41%)
		leucine-rich repeat	242..266	CDD:275380	11/34 (32%)
		leucine-rich repeat	267..290	CDD:275380	13/60 (22%)
		PCC	271..>350	CDD:188093	29/174 (17%)
		EGF	410..441	CDD:394967
		fn3	469..546	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100