DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and lrrc3ca

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_005156157.1	Gene:	lrrc3ca / 571711	ZFINID:	ZDB-GENE-080327-9	Length:	266	Species:	Danio rerio

Alignment Length:	328	Identity:	72/328 - (21%)
Similarity:	118/328 - (35%)	Gaps:	94/328 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLCGAIPVLLLLLLTLVILPPETTAF------CPSKCQCLGGEANSRALCVDAALEDVPIQLNPE 74
            ||.....|:.||..:.|::   |..|      |...|.|...|.:...
Zfish     7 WLLRHSVVMWLLFHSFVLM---TLCFHHAATSCSKGCYCSDSEGSFDG----------------- 51

  Fly    75 TKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHA 139
                       :|:..|     .|.:.::.|:|           .::.|.|.|..||::|:..:|
Zfish    52 -----------KTMRCS-----NLHLTEIPQDI-----------PNDTRRLYLDYNLLTSIPANA 89

  Fly   140 FKGLTNLLLLDLSFNRIETVHPTALSDL-ASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNR 203
            |..|..|..||||.|.:..:.|.|...| |||..|||::|.:.:|:.:.|..:..      |:|.
Zfish    90 FHDLPLLAELDLSHNELSLLEPGAFRGLTASLKFLDLSSNQLKTLDPDAFDSVRA------RSNL 148

  Fly   204 LLDVPASNLWHLH-----ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGL 263
                 ..|.||..     ||..||:.                   .:|:.|.|....:.|. .|.
Zfish   149 -----TGNPWHCDCRLQTALPRLDLE-------------------PVSLTGIVCQTFEPSD-AGA 188

  Fly   264 ISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRI 328
            ..:..|...|.:|.:|    |.|.:::..|......|:.:.:.....:.|.:|.....|::|:.:
Zfish   189 QGVPFLLAKDLDLCVV----LKKTTDVAMLVTMFGWFTMVISYLVYYVRHNQEDARRHLEYLKSL 249

  Fly   329 DSR 331
            .||
Zfish   250 PSR 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		leucine-rich repeat	98..121	CDD:275380	3/22 (14%)
		LRR_8	120..180	CDD:404697	25/60 (42%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	9/23 (39%)
		LRR	<161..>354	CDD:227223	40/177 (23%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	5/27 (19%)
		leucine-rich repeat	218..265	CDD:275380	8/46 (17%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	2/22 (9%)
		leucine-rich repeat	314..338	CDD:275380	5/18 (28%)
		LRR_8	337..397	CDD:404697
		leucine-rich repeat	339..360	CDD:275380
lrrc3ca	XP_005156157.1	LRRNT	36..72	CDD:214470	9/79 (11%)
		leucine-rich repeat	52..71	CDD:275378	5/34 (15%)
		LRR_RI	<60..>131	CDD:238064	27/81 (33%)
		leucine-rich repeat	72..95	CDD:275378	9/22 (41%)
		LRR_8	73..131	CDD:290566	25/57 (44%)
		leucine-rich repeat	96..120	CDD:275378	9/23 (39%)
		leucine-rich repeat	121..144	CDD:275378	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100