DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and igfals

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:XP_003198203.1 Gene:igfals / 570758 ZFINID:ZDB-GENE-061009-25 Length:614 Species:Danio rerio


Alignment Length:336 Identity:103/336 - (30%)
Similarity:168/336 - (50%) Gaps:17/336 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 ETKYINLTVNRIRTLE----FSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSS 134
            |.|.::||.|.::.::    ..||   ||:.|.|.||.|.|:..:.|.....||.|:||||.::.
Zfish   227 ELKELDLTGNYLKVIKANVFLKLP---KLQKLYLGQNQIVTVAPRAFVGMKSLRWLDLSRNRLTV 288

  Fly   135 LHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVF 199
            ||...|.||.:|.:|.||.|.|.::.|....||..|.||.|.:|.|.:|....|:|:..||||..
Zfish   289 LHDETFIGLQSLHVLRLSNNSINSLRPGTFRDLQYLEELCLYHNQIRALGVRVFEGLGHLEVLNL 353

  Fly   200 RNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLI 264
            .||||.:........|:.|..:.::.:....:.:..|:||.:|.::.:..:.::::...:|.||.
Zfish   354 ENNRLQEARMGTFMGLNHLAVMKLTGSCFHSLPDQVFKGLSKLHSIHLDRSCLTKVSSQSFSGLT 418

  Fly   265 SLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRID 329
            .|:.|.|..||:::|..|...:|..|..|:|..|:.:.:.:..|..|.:|..|.||. :.|..:.
Zfish   419 GLRRLFLQHNNISLVERQSFVELQRLQQLDLRFNKLTTITSNTFYGLKNLDYLLLSG-NLLHNLP 482

  Fly   330 SRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPV---DQLQKLY 391
            :.|.:...||..|.|:.| :|..|........|.:..:.::.|.|..|     ||   :.|.:|:
Zfish   483 AEALLPLQHLSWLDLSGN-KLELILNATIYMLPRLRYLNLKDNILVNL-----PVSIPESLDQLW 541

  Fly   392 LGDNPLQCNCS 402
            |..|..:|:||
Zfish   542 LSGNNWKCDCS 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 6/25 (24%)
leucine-rich repeat 98..121 CDD:275380 8/22 (36%)
LRR_8 120..180 CDD:404697 26/59 (44%)
leucine-rich repeat 122..145 CDD:275380 12/22 (55%)
leucine-rich repeat 146..169 CDD:275380 9/22 (41%)
LRR <161..>354 CDD:227223 55/192 (29%)
leucine-rich repeat 170..193 CDD:275380 9/22 (41%)
leucine-rich repeat 194..217 CDD:275380 9/22 (41%)
leucine-rich repeat 218..265 CDD:275380 8/46 (17%)
leucine-rich repeat 266..289 CDD:275380 8/22 (36%)
leucine-rich repeat 290..313 CDD:275380 6/22 (27%)
leucine-rich repeat 314..338 CDD:275380 6/23 (26%)
LRR_8 337..397 CDD:404697 17/62 (27%)
leucine-rich repeat 339..360 CDD:275380 6/20 (30%)
igfalsXP_003198203.1 LRRNT 48..81 CDD:279764
leucine-rich repeat 65..83 CDD:275380
leucine-rich repeat 84..107 CDD:275380
LRR_8 85..142 CDD:290566
leucine-rich repeat 108..131 CDD:275380
LRR_8 131..214 CDD:290566
leucine-rich repeat 132..155 CDD:275380
leucine-rich repeat 156..203 CDD:275380
leucine-rich repeat 204..227 CDD:275380 103/336 (31%)
LRR_RI <219..456 CDD:238064 75/231 (32%)
LRR_8 227..286 CDD:290566 23/61 (38%)
leucine-rich repeat 228..251 CDD:275380 6/25 (24%)
leucine-rich repeat 252..275 CDD:275380 8/22 (36%)
LRR_8 274..334 CDD:290566 26/59 (44%)
leucine-rich repeat 276..299 CDD:275380 12/22 (55%)
leucine-rich repeat 300..323 CDD:275380 9/22 (41%)
leucine-rich repeat 324..347 CDD:275380 9/22 (41%)
leucine-rich repeat 348..369 CDD:275380 8/20 (40%)
LRR_8 371..430 CDD:290566 12/58 (21%)
leucine-rich repeat 396..419 CDD:275380 4/22 (18%)
LRR_8 418..478 CDD:290566 18/60 (30%)
leucine-rich repeat 420..443 CDD:275380 8/22 (36%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_8 466..524 CDD:290566 14/59 (24%)
leucine-rich repeat 468..486 CDD:275380 5/18 (28%)
leucine-rich repeat 492..515 CDD:275380 6/23 (26%)
leucine-rich repeat 516..540 CDD:275380 6/28 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

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