DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lrrtm1

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_005160139.1	Gene:	lrrtm1 / 570385	ZFINID:	ZDB-GENE-050506-80	Length:	524	Species:	Danio rerio

Alignment Length:	607	Identity:	146/607 - (24%)
Similarity:	231/607 - (38%)	Gaps:	148/607 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLCGAIPVLLLLLLTLVI-LPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYIN 79
            |.....|.|:|..|.:|: :.|.....||..|:|    .|.:..|....|.|:|..|:....
Zfish    14 WPLRKPPGLILCSLGIVLKIVPLVGGSCPRLCRC----DNKQLYCEGLNLTDIPQNLSSAIG--- 71

  Fly    80 LTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLT 144
                                 |.|.:|.|..|...||...|:|..|.|..|.:..:.:.||:.|.
Zfish    72 ---------------------LSLRENNISELREGNFVGLSQLTWLYLDHNNIEIVEESAFERLR 115

  Fly   145 NLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPA 209
            .:..||||.||||::.......|.:|..|||:.|.:.|||.:.|.|:..|..|..|.|.|..:|.
Zfish   116 RIKELDLSTNRIESLPNGTFRPLPNLRILDLSYNRLQSLEPDLFHGLRKLTNLHLRYNALKFIPV 180

  Fly   210 SNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDN 274
            .......:::.||:..|.::.:..:||.||.:|..|.::.|.:.:::|:.|..||||:.|.:.:|
Zfish   181 RIFQDCRSMQFLDLGYNQLQSLARNSFAGLFKLTELHLEHNELVKVNLAHFPRLISLRTLYMRNN 245

  Fly   275 NLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHL 339
            ..|:|       ::.|.:                            ..|:|::||
Zfish   246 KATIV-------VNTLEW----------------------------TWDYLEKID---------- 265

  Fly   340 QTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVD---QLQKLYLGDNPLQCN- 400
                .:|| ::..|...:|:..|.:..:.:.||.|  .|..|..:|   .|..:.|..|..:|:
Zfish   266 ----FSNN-EIEYIEPHVFESVPKLNTLMLDSNKL--TYIDQRILDSWTSLSSITLSGNDWECSR 323

  Fly   401 --CSLL-WLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYI 462
              |:|. ||     .||:|      ....|.:.|....|..|::.|...|....:|.|.|
Zfish   324 NVCALASWL-----SNFQG------QRDSGLLCANPDIAQGEDILDAVYAFQLCEDNVEA----- 372

  Fly   463 AEQHIVNALHTTEPSAYELATSSSNRNSGIL-------RMDRQQIGCDIWRDKVRTRRKLLTMSE 520
                      ||     :..|.:.||..|.:       ..|.|    |:...:|.|....:|.|.
Zfish   373 ----------TT-----QTFTVTRNRPRGFIYEGPTKNPYDLQ----DMEGGEVVTNSLTVTASA 418

  Fly   521 GEITCPAHIVTVVCAVITCLLVAMIGISVLY-----------YLR--FVKRRRKLLHERGPMR-- 570
            .::.....|..||...:..:...:|.:.:||           .||  |..:|||...::...:
Zfish   419 DDLESTMKIHKVVTGTMALIFSFLIMVLMLYVSWKCFPAGVRQLRQCFTSQRRKQKQKQTMQQMA 483

  Fly   571 -TSKSIINVHDRILQGHNPGGL 591
             ||.|...|..:  ..|..|||
Zfish   484 TTSASEYYVDYK--PNHIDGGL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	0/21 (0%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	22/59 (37%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	44/192 (23%)
		leucine-rich repeat	170..193	CDD:275380	10/22 (45%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	13/46 (28%)
		leucine-rich repeat	266..289	CDD:275380	5/22 (23%)
		leucine-rich repeat	290..313	CDD:275380	1/22 (5%)
		leucine-rich repeat	314..338	CDD:275380	4/23 (17%)
		LRR_8	337..397	CDD:404697	14/62 (23%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
lrrtm1	XP_005160139.1	LRR_8	72..127	CDD:290566	20/54 (37%)
		leucine-rich repeat	72..92	CDD:275380	7/19 (37%)
		LRR_RI	90..322	CDD:238064	72/283 (25%)
		leucine-rich repeat	93..116	CDD:275380	7/22 (32%)
		LRR_8	115..175	CDD:290566	23/59 (39%)
		leucine-rich repeat	117..140	CDD:275380	9/22 (41%)
		leucine-rich repeat	141..164	CDD:275380	10/22 (45%)
		leucine-rich repeat	165..188	CDD:275380	6/22 (27%)
		leucine-rich repeat	189..212	CDD:275380	7/22 (32%)
		LRR_8	192..246	CDD:290566	17/53 (32%)
		leucine-rich repeat	213..236	CDD:275380	6/22 (27%)
		leucine-rich repeat	237..259	CDD:275380	6/56 (11%)
		LRR_8	261..318	CDD:290566	16/73 (22%)
		leucine-rich repeat	261..284	CDD:275380	7/37 (19%)
		leucine-rich repeat	285..305	CDD:275380	5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100