DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and lrrtm4l2

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:XP_009302017.1 Gene:lrrtm4l2 / 568695 ZFINID:ZDB-GENE-080327-14 Length:557 Species:Danio rerio


Alignment Length:732 Identity:137/732 - (18%)
Similarity:236/732 - (32%) Gaps:229/732 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 LLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEF 90
            ||..::::|..:....||..|:|.|    ....|.....:|||..::...:.::|..|.:..|  
Zfish    14 LLHASVLLLLSKGERMCPVSCRCEG----KIVYCESGGFQDVPENISLGCQGLSLRYNSLLLL-- 72

  Fly    91 SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNR 155
             ||:                    .|.:.::|..|.|..|.:|::.:.||:||..|..|.||.|:
Zfish    73 -LPY--------------------QFAHLNQLVWLYLDHNSISTVDRLAFQGLRRLKELILSSNK 116

  Fly   156 IETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKS 220
            |..:.......:.:|..|||:.|.:..|....|.|:..|:.|..|:|.:..:|........:|:.
Zfish   117 IAQLQNGTFETVPNLRNLDLSYNQMQDLVPGHFHGLRKLQNLHLRSNNIRSIPVRTFMECRSLEF 181

  Fly   221 LDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLS 285
            ||:..|.:..:...:|.||..|..|.::.|..|.::...|..|::|:.|.|..|.:..|......
Zfish   182 LDLGYNRLRTITRTTFLGLLRLTELHLEHNQFSRINFFLFPRLLNLQALYLQWNRIRTVVQGSPW 246

  Fly   286 KLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQL 350
            ....|..|:|.||.                         :|.:|...|....:|.||:|.:| ::
Zfish   247 TWHTLQKLDLSGNE-------------------------IQILDPAIFRCLPNLHTLNLESN-KI 285

  Fly   351 SDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLL----WLWRLVT 411
            |::.          |||.....|:.|             :.|..|...|:.|:.    ||     
Zfish   286 SNVS----------LEVVSSWISIST-------------INLAGNIWDCSSSICPLVSWL----- 322

  Fly   412 GNFEGVDPGMEHAAGGAVAALAKEADDEELAD---------EATAVASTDDGVAALAAYIAEQHI 467
            .||.|.      .....:.:..|....|.:.|         |...|..|.:....|..      .
Zfish   323 RNFRGT------RDASIICSTPKSLQGERVMDAVRNNSVCEEMFTVEPTTELTLLLTT------T 375

  Fly   468 VNALHTTEPSAYELAT--SSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITC---PA 527
            ...|:.|:|......|  :::.:.|.:..:.|......:   .||..::.||::...:..   |.
Zfish   376 TTTLYVTKPPTTTTTTPRTTTRQLSQVTHIQRLTPKVLL---PVRPEKEFLTVTPSSLPFTPEPE 437

  Fly   528 HIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGLG 592
            ........:|...:...:.:|::..:.:|..||                                
Zfish   438 FEHMTFHKIIAGSVALFLSVSLILLVIYVSWRR-------------------------------- 470

  Fly   593 LGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLEL 657
                                 ||:..:.||.|                             .:..
Zfish   471 ---------------------YPNSMRQLQQH-----------------------------SIRR 485

  Fly   658 ERYLAAQTIANEYRALKPWELPVKEADDEPEH-----LYERFDHYEYPDTHTMSKLKQAA----- 712
            :|                     ::...||||     |.|.:..|.:.:..||..|...|     
Zfish   486 KR---------------------RKKTREPEHNINSQLQEYYLSYNHANAETMDSLVNGACTCTI 529

  Fly   713 --SLNHSNSSAGPSPVP 727
              |....|:.:.|.|:|
Zfish   530 SGSRECENAYSYPRPLP 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 5/21 (24%)
leucine-rich repeat 98..121 CDD:275380 1/22 (5%)
LRR_8 120..180 CDD:404697 20/59 (34%)
leucine-rich repeat 122..145 CDD:275380 9/22 (41%)
leucine-rich repeat 146..169 CDD:275380 6/22 (27%)
LRR <161..>354 CDD:227223 45/192 (23%)
leucine-rich repeat 170..193 CDD:275380 8/22 (36%)
leucine-rich repeat 194..217 CDD:275380 5/22 (23%)
leucine-rich repeat 218..265 CDD:275380 13/46 (28%)
leucine-rich repeat 266..289 CDD:275380 5/22 (23%)
leucine-rich repeat 290..313 CDD:275380 5/22 (23%)
leucine-rich repeat 314..338 CDD:275380 3/23 (13%)
LRR_8 337..397 CDD:404697 13/59 (22%)
leucine-rich repeat 339..360 CDD:275380 6/20 (30%)
lrrtm4l2XP_009302017.1 LRR_8 <74..117 CDD:290566 16/62 (26%)
leucine-rich repeat 83..106 CDD:275380 9/22 (41%)
LRR_8 105..165 CDD:290566 18/59 (31%)
LRR_RI 107..307 CDD:238064 57/248 (23%)
leucine-rich repeat 107..130 CDD:275380 6/22 (27%)
leucine-rich repeat 131..154 CDD:275380 8/22 (36%)
LRR_8 153..213 CDD:290566 15/59 (25%)
leucine-rich repeat 155..178 CDD:275380 5/22 (23%)
leucine-rich repeat 179..202 CDD:275380 7/22 (32%)
leucine-rich repeat 203..226 CDD:275380 6/22 (27%)
LRR_8 226..285 CDD:290566 18/84 (21%)
leucine-rich repeat 227..250 CDD:275380 5/22 (23%)
leucine-rich repeat 251..274 CDD:275380 8/47 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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