DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lrrn1

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001124166.1	Gene:	lrrn1 / 568527	ZFINID:	ZDB-GENE-071126-1	Length:	717	Species:	Danio rerio

Alignment Length:	676	Identity:	146/676 - (21%)
Similarity:	256/676 - (37%)	Gaps:	148/676 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLLLLLLTLVILPPETTAFCPSKCQC-----LGGEANSRAL----CVDAALEDVPIQLNPETKYI 78
            :..:|||.::.|....:..||..|.|     ...::..|..    |.|..|..:|..|:.:|:.:
Zfish    14 ICFILLLAVLGLSSVHSTECPQLCVCEIRPWFTPQSTYREATTVDCNDLHLTRIPGNLSADTQVL 78

  Fly    79 NLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGL 143
            .|..|.|......|...:.|..||||||....:........|:|.||:|..|.:..:...:.:.|
Zfish    79 LLQSNYIARTSEELEQLLNLTELDLSQNNFSNIRDIGLTNMSQLTTLHLEENQIVEMPDFSLQDL 143

  Fly   144 TNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVP 208
            |||..|.::.|:|.::.|.|.:.|.:|:.|.|.:|.:.:::...|:....||:|:...|.::.:
Zfish   144 TNLQELYINHNQISSIAPNAFAGLRNLLRLHLNSNRLKAIDSRWFESTPNLEILMIGENPVVGI- 207

  Fly   209 ASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSD 273
                        ||:           :|:.|..|.:|.:.|..::::..:||.||.:|:.|...|
Zfish   208 ------------LDL-----------NFKPLTNLRSLVLAGMELTDIPGNAFVGLDNLESLSFYD 249

  Fly   274 NNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTH 338
            |.|..||...|.||.||.:|:|..|...::....|.|:..|:||.::.:..|..||..|..:...
Zfish   250 NKLVRVPQTALQKLPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSIDRFALDNLPE 314

  Fly   339 LQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCS 402
            |..|...|||:.|.:....|:..|.:..:.:.:|:|.:||.|.. .:..|:::.:..|||:|:|.
Zfish   315 LTKLEATNNPKFSYVSRLAFRDLPALESLMLNNNALNSLYQATADSLPNLREISIHSNPLRCDCV 379

  Fly   403 LLWLWRLVTGNFEGV----------------------DPGMEHAAGGAVAALAKEADDEELADEA 445
            :.|:    :.|...:                      |......:|..:..::.:.....|..:.
Zfish   380 IQWM----SSNKTTIRFMEPLSMFCTMPIEVRGQRVRDVFSREPSGQCLPMISHDTFPNHLNLDI 440

  Fly   446 TAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNR-------------NSGILRMDR 497
            ......|               ..|:...||..| ..|.|.|:             ::|.||:..
Zfish   441 GMTVDLD---------------CRAMAEPEPEIY-WVTPSGNKVMMDTVSDKYQLNSAGTLRISY 489

  Fly   498 QQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKL 562
            .|:.                 ..|..||.|.........:|.:.|
Zfish   490 IQVD-----------------DSGHYTCVAQNTEGADTRVTAIRV-------------------- 517

  Fly   563 LHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQ---AH 624
               .|.:..|..::.::.:..:.|         |:.:..  .||...||.|....:.|::   .|
Zfish   518 ---NGTLLDSTQLMKIYVKHTESH---------SILVSW--KVNSNVMTSNLKWSSATMKIDNPH 568

  Fly   625 HHYHQAMPLQSHGGNGNH-----EYQ 645
            ..|...:|:..|..|..|     ||:
Zfish   569 ITYTAKVPVDVHEYNLTHLQPATEYE 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/21 (24%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	53/192 (28%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	7/23 (30%)
		LRR_8	337..397	CDD:404697	15/60 (25%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
lrrn1	NP_001124166.1	leucine-rich repeat	55..74	CDD:275380	5/18 (28%)
		LRR_RI	86..>276	CDD:238064	59/213 (28%)
		LRR_8	97..156	CDD:290566	19/58 (33%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	8/46 (17%)
		LRR_8	216..276	CDD:290566	22/59 (37%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		LRR_RI	242..401	CDD:238064	45/162 (28%)
		leucine-rich repeat	242..265	CDD:275380	10/22 (45%)
		LRR_8	264..324	CDD:290566	17/59 (29%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..314	CDD:275380	7/23 (30%)
		LRR_8	313..374	CDD:290566	15/60 (25%)
		leucine-rich repeat	315..337	CDD:275380	7/21 (33%)
		leucine-rich repeat	340..353	CDD:275378	2/12 (17%)
		leucine-rich repeat	364..376	CDD:275378	4/11 (36%)
		LRRCT	372..414	CDD:214507	7/45 (16%)
		IG_like	433..517	CDD:214653	18/116 (16%)
		Ig	441..517	CDD:299845	17/108 (16%)
		FN3	532..601	CDD:214495	16/74 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010