DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and lrrc4cb

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_005166545.1	Gene:	lrrc4cb / 564462	ZFINID:	ZDB-GENE-080327-5	Length:	631	Species:	Danio rerio

Alignment Length:	727	Identity:	164/727 - (22%)
Similarity:	261/727 - (35%)	Gaps:	229/727 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT 87
            :|||.|..||:........|||.|.|  ....|:.:|....|:|||..::..|:|:||..|:|:.
Zfish    29 LLLLALQLLVVAGLVRAQTCPSVCSC--SNQFSKVICTRRGLKDVPDGVSTNTRYLNLQDNQIQV 91

  Fly    88 LEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLS 152
            ::..                       :|::...|..|.||||.:.::...||.|||:|..|:|.
Zfish    92 IKVD-----------------------SFKHLRHLEILQLSRNHIRNIEIGAFNGLTSLNTLELF 133

  Fly   153 FNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHA 217
            .||:.|:...|...|:.|.||.|.||.|.|:..:.|.                        .|.:
Zfish   134 DNRLTTIPNGAFEYLSKLKELWLRNNPIESIPSDAFS------------------------RLPS 174

  Fly   218 LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQ 282
            |:.||:.             .||.|          |.:...||:||.:|::|:|...||..||
Zfish   175 LRRLDLG-------------ELKRL----------SYISSGAFQGLSNLRYLNLGMCNLKEVP-- 214

  Fly   283 QLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNN 347
            .:..|..|..|.:.||:.:.:...:|..|.||::|.:.... :|.|:..:|.|...|:.|:|.:|
Zfish   215 NIQPLIRLDELEMSGNQLTVIQPSSFKGLVHLQKLWMMHAQ-VQTIERNSFDDLHSLRELNLAHN 278

  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWL-WRL-- 409
             .|:.:|..|:.                       |:..||:::|..||..|||.:||| |.|
Zfish   279 -NLTFLPHDLYT-----------------------PLHHLQRVHLHHNPWNCNCDILWLSWWLRE 319

  Fly   410 -----------------VTGNFEG--------------VDPGMEHAAGGAVAALAKEADDEELAD 443
                             :.|.:.|              ::|.::......:||        ||..
Zfish   320 TVPTNTSCCARCNSPPSLKGRYIGELDQSYFQCYAPVIIEPPVDLNLTEGMAA--------ELKC 376

  Fly   444 EATAVAST----------------------DDGVAALAAYIAEQ------HIVNALHTTEPSAYE 480
            ...:|.|.                      :||.........:.      ::.|.|..|..||..
Zfish   377 RTNSVTSVSWLTPNGSIITHGTLKMRINVQNDGTLNFTNVTLQDTGTYTCYVSNMLGNTSASAIL 441

  Fly   481 LATSSSNRN-SGILRMDRQQIGCDI-------------WRDKVRTRRKLLTMSEGEITCPA---- 527
            ..||..|.. |....:..:.|...|             |.....||...:. :|...|.|.
Zfish   442 NVTSVDNSGFSYFTTVTVETIETPIDGESRTPVQPSFGWASSSTTRGTPIA-TERAYTIPVTEID 505

  Fly   528 ---------HIVTVVCAVITCL----LVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVH 579
                     .::.....:|.|.    |:|.:.:.:.|.:|  |:..:..|: ||.| |..||:||
Zfish   506 IDGALNGLEEVMKTTKIIIGCFVAITLMAAVMLIIFYKMR--KQHHQQDHD-GPSR-SMEIISVH 566

  Fly   580 DRI-----LQGHNPGGLGLGMSMTL-----GGGNHVNGLGMTLNYPHHAQTLQA-HHHYHQAMPL 633
            :.:     ::.|          :||     ...||.|......|   |...|.: |...|:.:.:
Zfish   567 EDLTRVPAMESH----------LTLPPLEHDHYNHYNSYKTAYN---HVSALSSLHSSVHEPLLI 618

  Fly   634 QSHGGNGNHEYQ 645
            |:...:...|.|
Zfish   619 QASSKDNVQETQ 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/21 (29%)
		leucine-rich repeat	98..121	CDD:275380	1/22 (5%)
		LRR_8	120..180	CDD:404697	25/59 (42%)
		leucine-rich repeat	122..145	CDD:275380	10/22 (45%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	49/192 (26%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	1/22 (5%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	12/59 (20%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
lrrc4cb	XP_005166545.1	LRRNT	48..81	CDD:214470	12/34 (35%)
		LRR_8	77..137	CDD:290566	22/82 (27%)
		leucine-rich repeat	79..102	CDD:275380	7/45 (16%)
		LRR_RI	82..>281	CDD:238064	70/272 (26%)
		leucine-rich repeat	103..126	CDD:275380	10/22 (45%)
		LRR_8	125..180	CDD:290566	21/78 (27%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	10/46 (22%)
		leucine-rich repeat	175..199	CDD:275380	11/46 (24%)
		leucine-rich repeat	200..221	CDD:275380	8/22 (36%)
		LRR_8	221..280	CDD:290566	17/60 (28%)
		leucine-rich repeat	222..245	CDD:275380	6/22 (27%)
		leucine-rich repeat	246..269	CDD:275380	6/23 (26%)
		leucine-rich repeat	270..291	CDD:275380	7/44 (16%)
		LRRCT	302..352	CDD:214507	12/49 (24%)
		I-set	355..443	CDD:254352	14/95 (15%)
		Ig	372..439	CDD:143165	10/74 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910