DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lingo4b

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001082850.1	Gene:	lingo4b / 559074	ZFINID:	ZDB-GENE-091214-3	Length:	604	Species:	Danio rerio

Alignment Length:	416	Identity:	128/416 - (30%)
Similarity:	191/416 - (45%)	Gaps:	52/416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LC---GAIPVLLL--LLLTLVILPPETTAFCPSKCQCLGG--EANSRALCVDAALEDVPIQLNPE 74
            ||   ||..||||  |.|:...||      ||.:|.|...  |.|    |....|..||..|...
Zfish     5 LCGQRGAWTVLLLWCLNLSAADLP------CPQRCSCSRDPLEVN----CSSRHLTAVPEGLPTN 59

  Fly    75 TKYINLTVNRIRTL---EFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLH 136
            .|.::|:.|:::||   :||  ...|||.||||:|||..:..:.|:....||.|.:..|.:..|.
Zfish    60 AKRLDLSGNQLKTLARRQFS--SLSKLEDLDLSENIISMIEVETFQGLKNLRYLRIKNNRLKILP 122

  Fly   137 KHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRN 201
            ...|.||:||..||:|.|.|.........|:.:|.:||...|::|.:....|.|:..|:.|....
Zfish   123 VGVFSGLSNLRRLDISENEILVFLDYTFRDMINLQQLDAGENDLVFISQRAFVGLQALKELNVDR 187

  Fly   202 NRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSV-QGNVMSELDLSAFEGLIS 265
            :.|..:|...|..|.:|..|.:....:..:.|::|..|.:|..|.: ..:.:..|:.::..|| :
Zfish   188 SNLTSIPTEALSQLQSLTKLRLRKLTISVLPNNAFRRLHQLRTLQILHWSSLEMLNSNSLVGL-N 251

  Fly   266 LKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDS 330
            |..|.|::.||:.:|...|..|:.|.||:|..|..:.:......:|..|:||||...:.| ||:.
Zfish   252 LTTLVLTNCNLSAIPYSPLRHLAYLQYLDLSYNPITSIQGNLLGDLLRLQELHLVGGNLL-RIEP 315

  Fly   331 RAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGD 394
            .||...:..:.|:::                         ||.|.||..:.| .|..||.|.|..
Zfish   316 GAFRGLSRFRLLNVS-------------------------SNRLSTLEESAFHSVGNLQTLRLDR 355

  Fly   395 NPLQCNCSLLWLWRLVTG-NFEGVDP 419
            |||.|:|.|||:.|.... :|:|..|
Zfish   356 NPLACDCRLLWVMRRRRRLDFDGRQP 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/24 (29%)
		leucine-rich repeat	98..121	CDD:275380	10/22 (45%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	49/193 (25%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	10/47 (21%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	10/23 (43%)
		LRR_8	337..397	CDD:404697	13/60 (22%)
		leucine-rich repeat	339..360	CDD:275380	1/20 (5%)
lingo4b	NP_001082850.1	LRRNT	28..61	CDD:214470	12/42 (29%)
		leucine-rich repeat	41..62	CDD:275380	7/24 (29%)
		LRR	<56..304	CDD:227223	74/250 (30%)
		leucine-rich repeat	63..83	CDD:275380	6/21 (29%)
		leucine-rich repeat	84..107	CDD:275380	10/22 (45%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..251	CDD:275380	10/47 (21%)
		leucine-rich repeat	228..250	CDD:275380	3/21 (14%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		leucine-rich repeat	276..297	CDD:275380	5/20 (25%)
		LRR_8	299..358	CDD:316378	23/84 (27%)
		leucine-rich repeat	300..321	CDD:275380	10/21 (48%)
		leucine-rich repeat	324..344	CDD:275380	7/44 (16%)
		I-set	415..498	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010