DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and flrt3

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001243575.1	Gene:	flrt3 / 558864	ZFINID:	ZDB-GENE-030131-1988	Length:	649	Species:	Danio rerio

Alignment Length:	819	Identity:	175/819 - (21%)
Similarity:	282/819 - (34%)	Gaps:	266/819 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFS 91
            |||.|. .|..|:|.|||:|:|.|    :...|.|..|..:|..:..:...:.|..|||::.  .
Zfish    17 LLLGLA-NPLMTSASCPSQCRCDG----TFIYCNDRDLTSIPSGIPEDATVLFLQNNRIKSA--G 74

  Fly    92 LPFYMKLEILDLSQ-NIIETLGSKNFEYQSELRTL--NLSRNLVSSLHKHAFKGLTNLLLLDLSF 153
            :|       .||.: |.:|    |.:.|.:.|...  ||..| |..||              |..
Zfish    75 IP-------TDLRRLNGVE----KIYLYCNNLDEFPTNLPLN-VKELH--------------LQE 113

  Fly   154 NRIETVHPTALSDLASLVELDLTNNNI--VSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLH 216
            |.|.|:...:|:.:..:.||.|.:|::  ||:|:..|:..|.|.:|....|.|..:|:.....:.
Zfish   114 NNIRTITHASLAQIPFIEELHLDDNSVSAVSIEEGAFRDSNHLRLLFLSRNHLSTIPSGLPMTIE 178

  Fly   217 ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLS--AFEGLISLKHLDLSDNNLTMV 279
            .|:..|   |.:..:...|.:.|..|..|.:.||:::...:.  |...|::|..|.|..|:||..
Zfish   179 ELRFDD---NRISSISEASLQDLINLKRLVLDGNLLNNRGIGEMALVNLVNLTELSLVRNSLTSP 240

  Fly   280 PTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHL 344
            |.....  |:|..|||..|..:.:|..||.   .||:|:  |||                    |
Zfish   241 PANLPG--SSLEKLNLQDNHINHVPPGAFA---FLRQLY--RLD--------------------L 278

  Fly   345 NNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWL--W 407
            :.| .||.:||.:|:                       .:|.|.:|.|.:||..|||.:.|:  |
Zfish   279 SGN-NLSSLPMGVFE-----------------------DLDNLTQLLLRNNPWHCNCRMKWVRDW 319

  Fly   408 -RLVTG--NFEG-VDPGMEHAAGGAVAALAKE---ADDEELADEATAVASTDDGVAALAAYIAEQ 465
             |.:..  |..| :..|.:...|.|:..|:.|   ..|.|:
Zfish   320 LRTLPSKVNVRGFMCQGPDKVKGMAIKDLSTELFGCSDTEI------------------------ 360

  Fly   466 HIVNALHTTEPSAYELATSSSNRNSGILRMDRQQ-----------IGCDI---WRDKVRTRRKLL 516
                      |:.||.:|.|:.     |...|.|           .|.|:   :|....:.||::
Zfish   361 ----------PTTYETSTVSNT-----LPPSRPQWPSYVTKRPVVKGPDLGRNYRSTTPSSRKII 410

  Fly   517 TMS-EGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHD 580
            |:| :.......||...|...:|.|.::.:               ||.|       |.:..::.:
Zfish   411 TISVKSSSAETVHISWRVSQPMTALRLSWL---------------KLGH-------SPAFGSITE 453

  Fly   581 RILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQAHHHYHQAM-PLQSHGGNGNHEY 644
            .|:||.....|                          ...|:....|...| |:::     ::.|
Zfish   454 TIVQGERTEYL--------------------------LTALEPESSYRICMVPMET-----SNIY 487

  Fly   645 QQTTLPQLDKLELERYLAAQTIANEYRALKPWELPVKEADDEPEHLYERFDHYEYPDTHTMSKLK 709
            .....|          :..:|.....:|..|.....:|.:.||         |:..:....|.:.
Zfish   488 LSDETP----------VCIETETGSLKAYNPTTTLNREQEKEP---------YKNSNLPLASIIG 533

  Fly   710 QAASL------------NHSNSSAGPSPVPPSSGKPHV-VYVXRGRGTGERVSQI-NTDIEMVGL 760
            .|.:|            .|.|.|........:.|:... .|...|......:.:| .|..:|:.:
Zfish   534 GAVALLAIIMLALVCWYVHRNGSLFSRNCTYNKGRRRKDDYAEAGTKKDNSILEIRETSFQMIPI 598

  Fly   761 NHLHL----------------------HHHHHNNNNNYR 777
            ||:.:                      |..:..||.:||
Zfish   599 NHMPVSKEEFVIHTIFPPNGLSLYKSPHSENSINNRSYR 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/21 (24%)
		leucine-rich repeat	98..121	CDD:275380	6/23 (26%)
		LRR_8	120..180	CDD:404697	16/61 (26%)
		leucine-rich repeat	122..145	CDD:275380	7/24 (29%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	52/196 (27%)
		leucine-rich repeat	170..193	CDD:275380	8/24 (33%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	11/48 (23%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	12/59 (20%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
flrt3	NP_001243575.1	LRRNT	31..61	CDD:214470	10/33 (30%)
		leucine-rich repeat	61..84	CDD:275378	7/31 (23%)
		leucine-rich repeat	85..105	CDD:275380	6/23 (26%)
		LRR_RI	104..327	CDD:238064	75/291 (26%)
		leucine-rich repeat	106..129	CDD:275380	8/36 (22%)
		leucine-rich repeat	130..155	CDD:275380	8/24 (33%)
		LRR_8	131..211	CDD:290566	23/82 (28%)
		leucine-rich repeat	156..176	CDD:275380	5/19 (26%)
		leucine-rich repeat	177..200	CDD:275380	5/25 (20%)
		LRR_8	178..237	CDD:290566	15/61 (25%)
		leucine-rich repeat	201..226	CDD:275380	6/24 (25%)
		leucine-rich repeat	227..248	CDD:275380	7/22 (32%)
		LRR_8	247..306	CDD:290566	26/107 (24%)
		leucine-rich repeat	249..272	CDD:275380	9/25 (36%)
		leucine-rich repeat	273..296	CDD:275380	11/68 (16%)
		LRRCT	305..356	CDD:214507	15/50 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960