DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and lgr4

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001340791.1 Gene:lgr4 / 558825 ZFINID:ZDB-GENE-111013-1 Length:971 Species:Danio rerio


Alignment Length:404 Identity:110/404 - (27%)
Similarity:183/404 - (45%) Gaps:64/404 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 TTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYMKLEILD 102
            |.|.|...|:|   :.:..|.|....|..||..|:..|.|:::::|               .|.:
Zfish    28 TPATCSPLCRC---DEDGGADCSGRGLTSVPTGLSAFTYYLDISMN---------------NITE 74

  Fly   103 LSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDL 167
            |..|:.     :|..|..|||   |:.|.::.:|..|..||..|.:|.|..|:::||...||.:|
Zfish    75 LPANVF-----RNLPYLEELR---LAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKNL 131

  Fly   168 ASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVR 232
            .:|..|.|..|:|.|:.::.|:|:..|..|...:|.|.:||.|.|.|...|::|.::||.:..:.
Zfish   132 NALQSLRLDANHITSVPEDSFEGLQQLRHLWLDDNSLTEVPISPLQHQSNLQALTLALNRITHIP 196

  Fly   233 NDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGG 297
            :::|..|..|:.|.:..|.:.|:..:.|.||.:|:.|||:.|||.:.| :.:..|..|..|....
Zfish   197 DNAFANLSSLVVLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNLKIFP-EAIQMLPKLKELGFHS 260

  Fly   298 NRFSQLPAVAFLNLFHLRELHL--SRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSD-------- 352
            |..:.:|..||.....||.:||  :.|.|   :.:.||.:.:.|.:|.|.....:.|        
Zfish   261 NNIASIPEGAFCRNSLLRTIHLFDNPLSF---VGTTAFQNLSDLHSLMLRGASMMQDFPSLTGTI 322

  Fly   353 --------------IPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSL 403
                          ||..|.:....:..|.:..|.::.|.|.|..| :||.:.|..|.::     
Zfish   323 NLESLTLTGTKIRSIPADLCEDLTVLRTVDLSYNDIEDLPSFQGCV-RLQDINLQHNQIK----- 381

  Fly   404 LWLWRLVTGNFEGV 417
                ::..|.|:|:
Zfish   382 ----QIDRGTFQGM 391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 3/21 (14%)
leucine-rich repeat 98..121 CDD:275380 5/22 (23%)
LRR_8 120..180 CDD:404697 22/59 (37%)
leucine-rich repeat 122..145 CDD:275380 8/22 (36%)
leucine-rich repeat 146..169 CDD:275380 9/22 (41%)
LRR <161..>354 CDD:227223 60/216 (28%)
leucine-rich repeat 170..193 CDD:275380 8/22 (36%)
leucine-rich repeat 194..217 CDD:275380 9/22 (41%)
leucine-rich repeat 218..265 CDD:275380 13/46 (28%)
leucine-rich repeat 266..289 CDD:275380 9/22 (41%)
leucine-rich repeat 290..313 CDD:275380 6/22 (27%)
leucine-rich repeat 314..338 CDD:275380 8/25 (32%)
LRR_8 337..397 CDD:404697 17/81 (21%)
leucine-rich repeat 339..360 CDD:275380 7/42 (17%)
lgr4NP_001340791.1 LRR 1 58..82 7/43 (16%)
leucine-rich repeat 64..85 CDD:275380 6/40 (15%)
LRR_8 84..144 CDD:316378 23/62 (37%)
LRR 2 84..106 8/24 (33%)
leucine-rich repeat 86..109 CDD:275380 9/25 (36%)
LRR 3 107..130 9/22 (41%)
leucine-rich repeat 110..133 CDD:275380 9/22 (41%)
LRR 4 131..154 8/22 (36%)
leucine-rich repeat 134..157 CDD:275380 8/22 (36%)
LRR 137..>452 CDD:227223 72/269 (27%)
LRR 5 156..178 8/21 (38%)
leucine-rich repeat 158..181 CDD:275380 9/22 (41%)
LRR 6 179..202 5/22 (23%)
leucine-rich repeat 182..205 CDD:275380 6/22 (27%)
LRR 7 204..226 5/21 (24%)
leucine-rich repeat 206..229 CDD:275380 7/22 (32%)
LRR 8 227..250 9/23 (39%)
leucine-rich repeat 230..252 CDD:275380 9/22 (41%)
LRR_8 251..308 CDD:316378 17/59 (29%)
LRR 9 251..273 6/21 (29%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
LRR 10 275..297 8/24 (33%)
leucine-rich repeat 277..298 CDD:275380 8/23 (35%)
LRR 11 299..321 4/21 (19%)
LRR 12 322..344 3/21 (14%)
LRR 13 345..366 4/20 (20%)
leucine-rich repeat 348..369 CDD:275380 6/21 (29%)
LRR 14 367..390 7/32 (22%)
leucine-rich repeat 370..393 CDD:275380 7/31 (23%)
LRR 15 391..414 0/1 (0%)
leucine-rich repeat 394..415 CDD:275380
LRR 16 416..438
leucine-rich repeat 418..438 CDD:275380
7tmA_LGR4 527..811 CDD:320483
TM helix 1 528..554 CDD:320483
TM helix 2 562..587 CDD:320483
TM helix 3 607..637 CDD:320483
TM helix 4 649..679 CDD:320483
TM helix 5 698..727 CDD:320483
TM helix 6 736..766 CDD:320483
TM helix 7 779..804 CDD:320483
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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