DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fili and Lrrn1

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001032440.1 Gene:Lrrn1 / 500280 RGDID:1564145 Length:716 Species:Rattus norvegicus


Alignment Length:678 Identity:160/678 - (23%)
Similarity:269/678 - (39%) Gaps:114/678 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 WLCGAIPVLLLLLLTLV---ILPPETTAFCPSKCQC-----LGGEANSRAL----CVDAALEDVP 68
            |:     ||.||:.:|.   ||..|    ||..|.|     ...::..|..    |.|..|..:|
  Rat    12 WM-----VLGLLIPSLTESSILNSE----CPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIP 67

  Fly    69 IQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVS 133
            ..|:.:|:.:.|..|.|......|.....|..||.|||....:........::|.||:|..|.:|
  Rat    68 GNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIS 132

  Fly   134 SLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLV 198
            .:..:..:.|:||..|.::.|:|.::...|.|.|.:|:.|.|.:|.:..::...|.....||:|:
  Rat   133 EMTDYCLQDLSNLQELYINHNQISSISANAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILM 197

  Fly   199 FRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGL 263
            ...|.::.:             |||           :|..|..|.:|.:.|..::::..:|..||
  Rat   198 IGENPVIGI-------------LDM-----------NFRPLSNLRSLVLAGMYLTDIPGNALVGL 238

  Fly   264 ISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRI 328
            .||:.|...||.|..||...|.|:.||.:|:|..|...::....|.|:..|:||.::.:..|..:
  Rat   239 DSLESLSFYDNKLIKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSV 303

  Fly   329 DSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYL 392
            |..|..:...|..|...|||:||.|....|:..|.:..:.:.:|:|..:|.... .:..|:::.:
  Rat   304 DRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAVYQKTVESLPNLREISI 368

  Fly   393 GDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAA------GGAVAALAKEADDEELADEATAVAST 451
            ..|||:|:|.:.|:....| |...::|.....|      |..|    ||...::.:::...:.|.
  Rat   369 HSNPLRCDCVIHWINSNKT-NIRFMEPLSMFCAMPPEYRGQQV----KEVLIQDSSEQCLPMISH 428

  Fly   452 DDGVAALAAYIAEQHIVN--ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRK 514
            |.....|...|.....::  |:...||..|.:.                .||..|..:.:..:.|
  Rat   429 DTFPNHLNMDIGTTLFLDCRAMAEPEPEIYWVT----------------PIGNKITVETLSDKYK 477

  Fly   515 LLTMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVH 579
            |  .|||.:.. |:|........||:...:.|...         |...:...|.:.....::.::
  Rat   478 L--SSEGTLEI-ANIQIEDSGRYTCVAQNVQGADT---------RVATIKVNGTLLDGAQVLKIY 530

  Fly   580 DRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTLQ---AHHHYHQAMPLQSHGGNGN 641
            .:..:.|         |:.:..  .||...||.|....:.|::   .|..|...:|:..      
  Rat   531 VKQTESH---------SILVSW--KVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDV------ 578

  Fly   642 HEYQQTTL-PQLDKLELERYLAAQTIAN 668
            |||..|.| |..|      |....|::|
  Rat   579 HEYNLTHLQPSTD------YEVCLTVSN 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 5/21 (24%)
leucine-rich repeat 98..121 CDD:275380 6/22 (27%)
LRR_8 120..180 CDD:404697 19/59 (32%)
leucine-rich repeat 122..145 CDD:275380 7/22 (32%)
leucine-rich repeat 146..169 CDD:275380 7/22 (32%)
LRR <161..>354 CDD:227223 53/192 (28%)
leucine-rich repeat 170..193 CDD:275380 5/22 (23%)
leucine-rich repeat 194..217 CDD:275380 4/22 (18%)
leucine-rich repeat 218..265 CDD:275380 11/46 (24%)
leucine-rich repeat 266..289 CDD:275380 9/22 (41%)
leucine-rich repeat 290..313 CDD:275380 6/22 (27%)
leucine-rich repeat 314..338 CDD:275380 6/23 (26%)
LRR_8 337..397 CDD:404697 15/60 (25%)
leucine-rich repeat 339..360 CDD:275380 9/20 (45%)
Lrrn1NP_001032440.1 leucine-rich repeat 54..73 CDD:275380 5/18 (28%)
LRR <68..372 CDD:227223 84/327 (26%)
LRR 1 73..95 5/21 (24%)
leucine-rich repeat 74..96 CDD:275380 5/21 (24%)
LRR 2 96..117 6/20 (30%)
leucine-rich repeat 97..120 CDD:275380 6/22 (27%)
LRR 3 120..141 6/20 (30%)
leucine-rich repeat 121..144 CDD:275380 7/22 (32%)
LRR 4 144..165 6/20 (30%)
leucine-rich repeat 145..168 CDD:275380 7/22 (32%)
LRR 5 168..189 5/20 (25%)
leucine-rich repeat 169..192 CDD:275380 5/22 (23%)
LRR 6 192..213 8/44 (18%)
leucine-rich repeat 193..216 CDD:275380 9/46 (20%)
LRR 7 216..237 4/20 (20%)
leucine-rich repeat 217..240 CDD:275380 6/22 (27%)
LRR 8 240..261 9/20 (45%)
leucine-rich repeat 241..264 CDD:275380 9/22 (41%)
LRR 9 264..285 6/20 (30%)
leucine-rich repeat 265..288 CDD:275380 6/22 (27%)
leucine-rich repeat 289..313 CDD:275380 6/23 (26%)
leucine-rich repeat 314..335 CDD:275380 9/20 (45%)
leucine-rich repeat 339..362 CDD:275378 3/22 (14%)
leucine-rich repeat 363..375 CDD:275378 4/11 (36%)
LRRCT 371..419 CDD:214507 14/52 (27%)
I-set 429..516 CDD:400151 21/114 (18%)
Ig strand A' 433..438 CDD:409353 1/4 (25%)
Ig strand B 441..450 CDD:409353 0/8 (0%)
Ig strand C 456..460 CDD:409353 1/3 (33%)
Ig strand C' 463..465 CDD:409353 1/1 (100%)
Ig strand D 478..481 CDD:409353 1/4 (25%)
Ig strand E 482..487 CDD:409353 1/5 (20%)
Ig strand F 495..503 CDD:409353 2/7 (29%)
Ig strand G 506..516 CDD:409353 2/18 (11%)
FN3 531..600 CDD:214495 20/91 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..716
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8997
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

Return to query results.
Submit another query.