DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lingo1b

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001004576.1	Gene:	lingo1b / 447837	ZFINID:	ZDB-GENE-040912-136	Length:	622	Species:	Danio rerio

Alignment Length:	412	Identity:	125/412 - (30%)
Similarity:	192/412 - (46%)	Gaps:	50/412 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86
            |:|:|:|.|  :|....|. |||:|:|...|.:  .:|....|..:|..:..:|:.::|:.||::
Zfish    27 PILILMLGT--VLSGSATG-CPSRCECSAQERS--VVCHRRKLITLPEGIPIDTRLLDLSKNRLK 86

  Fly    87 TL---EFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLL 148
            .:   ||.  .|.:||.|.|::|||..:....|.....||||.|..|.:..:....|.||:||..
Zfish    87 AINPEEFL--NYPQLEDLQLNENIISVIEPGAFSNLLGLRTLGLRNNNLKLIQLGVFTGLSNLTR 149

  Fly   149 LDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLW 213
            ||:|.|:|..:......:|.:|.||::.:|::|.:....|.|:::||.|......|..||.....
Zfish   150 LDISENKIVILLDYMFQELYNLKELEVGDNDLVFISHRAFHGLSSLEQLTMERCNLTSVPTEAFS 214

  Fly   214 HLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQG-NVMSELDLSAFEGLISLKHLDLSDNNLT 277
            |||.|.:|.:....|..:|:.||..|..|..|.:.. .::..|...:..|| ::..|.:::.|||
Zfish   215 HLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIANWPLLESLTAKSLHGL-NITTLSITNCNLT 278

  Fly   278 MVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHL--SRLDFLQRIDSRAFVDNTHLQ 340
            .||...:..|..|.:.||..|....:......||..|:..||  .|   |..|:..:|....:|:
Zfish   279 AVPYVAIQHLVYLRFFNLSFNPIEVVEGNKMHNLLRLQAFHLVGGR---LVSIEPYSFKGLNYLR 340

  Fly   341 TLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLL 404
            .|:::                         ||||.||..:.| .|..|:.|.|.||||.|:|.||
Zfish   341 VLNVS-------------------------SNSLSTLEESAFHSVGNLETLALHDNPLACDCRLL 380

  Fly   405 WL----WRLVTGNFEGVDPGME 422
            |:    |||   ||....|..|
Zfish   381 WVFRRRWRL---NFNRQQPSCE 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/24 (29%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	51/195 (26%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	12/47 (26%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	7/25 (28%)
		LRR_8	337..397	CDD:404697	15/60 (25%)
		leucine-rich repeat	339..360	CDD:275380	2/20 (10%)
lingo1b	NP_001004576.1	LRRNT	43..77	CDD:214470	10/36 (28%)
		LRR 1	74..95		6/22 (27%)
		leucine-rich repeat	75..98	CDD:275380	7/24 (29%)
		LRR_8	76..133	CDD:290566	20/58 (34%)
		LRR_RI	78..>315	CDD:238064	72/239 (30%)
		LRR 2	98..119		8/20 (40%)
		leucine-rich repeat	99..146	CDD:275380	17/46 (37%)
		LRR 3	122..143		7/20 (35%)
		LRR_8	130..181	CDD:290566	16/50 (32%)
		LRR 4	146..167		7/20 (35%)
		leucine-rich repeat	147..170	CDD:275380	7/22 (32%)
		LRR_8	170..226	CDD:290566	18/55 (33%)
		LRR 5	170..191		6/20 (30%)
		leucine-rich repeat	171..194	CDD:275380	7/22 (32%)
		LRR 6	194..215		6/20 (30%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		LRR 7	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		leucine-rich repeat	243..290	CDD:275380	12/47 (26%)
		LRR_8	266..325	CDD:290566	17/61 (28%)
		LRR 8	266..287		6/20 (30%)
		LRR 9	290..311		4/20 (20%)
		leucine-rich repeat	291..338	CDD:275380	13/49 (27%)
		LRR_8	314..373	CDD:290566	22/86 (26%)
		LRR 10	314..335		7/23 (30%)
		LRR 11	338..359		9/45 (20%)
		leucine-rich repeat	339..362	CDD:275380	10/47 (21%)
		TPKR_C2	371..424	CDD:301599	15/32 (47%)
		IG_like	438..516	CDD:214653
		Ig	441..516	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010