DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and LRRC24

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001019849.2	Gene:	LRRC24 / 441381	HGNCID:	28947	Length:	513	Species:	Homo sapiens

Alignment Length:	586	Identity:	129/586 - (22%)
Similarity:	189/586 - (32%)	Gaps:	174/586 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86
            |.||.|||.|:   |...|.||:.|:|........||    .|..||:.:.|.|:.:.|..|.|.
Human     6 PALLPLLLLLL---PLRAAGCPAACRCYSATVECGAL----RLRVVPLGIPPGTQTLFLQDNNIA 63

  Fly    87 TLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDL 151
            .||               ...:..|.:        ||.|.|..|.:.:|...||:....||
Human    64 RLE---------------PGALAPLAA--------LRRLYLHNNSLRALEAGAFRAQPRLL---- 101

  Fly   152 SFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLH 216
                                ||.||:|.:..|....|.|:..|.||....|:|..:......||.
Human   102 --------------------ELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLP 146

  Fly   217 ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPT 281
            .|:.|.:..|.:|.:.:.:..||..|..|.:..|.:..:...|.:.|.||:.|.|::|     |.
Human   147 RLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTEN-----PW 206

  Fly   282 QQLSKLSNL-TYLNLGGNRF----------SQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335
            :....|..| .::..||.|.          ::.|.:|..:|..:.  |.|.:         ....
Human   207 RCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVS--HSSLI---------CIPP 260

  Fly   336 NTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCN 400
            :.|:|.|.|..|                                            ||:: |:..
Human   261 SVHVQPLELTAN--------------------------------------------LGED-LRVA 280

  Fly   401 CSL------LWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDE------------ELADEATA 447
            |..      |..||.|....||.........||.:......|.|.            ..|.:...
Human   281 CQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYEC 345

  Fly   448 VASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTR 512
            .||...|    ||.:..:.:||| ...:|.........:.|.:|  ...|.:.|...:|
Human   346 EASNAGG----AARVPFRLLVNA-SRQQPQQPAQPPPPAARPAG--SEPRPEAGSMAFR------ 397

  Fly   513 RKLLTMSEGEITCPAHIVTVVCAVITC-LLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSII 576
                  :.|..|..|....:....:|. ||||||          .:|||:....|||.......:
Human   398 ------ALGVATQTAIAAAIALLALTALLLVAMI----------CRRRRRRKKARGPPGEGALFV 446

  Fly   577 N 577
            |
Human   447 N 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/21 (29%)
		leucine-rich repeat	98..121	CDD:275380	1/22 (5%)
		LRR_8	120..180	CDD:404697	15/59 (25%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	2/22 (9%)
		LRR	<161..>354	CDD:227223	47/203 (23%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	7/33 (21%)
		leucine-rich repeat	314..338	CDD:275380	2/23 (9%)
		LRR_8	337..397	CDD:404697	7/59 (12%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
LRRC24	NP_001019849.2	LRR_RI	49..>158	CDD:238064	36/155 (23%)
		LRR_8	<50..86	CDD:290566	13/58 (22%)
		LRR 1	51..72		6/35 (17%)
		leucine-rich repeat	53..75	CDD:275380	6/36 (17%)
		LRR 2	75..96		8/28 (29%)
		LRR_8	76..134	CDD:290566	22/81 (27%)
		leucine-rich repeat	76..99	CDD:275380	8/22 (36%)
		LRR 3	99..120		9/44 (20%)
		leucine-rich repeat	100..123	CDD:275380	10/46 (22%)
		LRR_8	123..205	CDD:290566	23/86 (27%)
		LRR 4	123..144		5/20 (25%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR 5	147..168		4/20 (20%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR 6	171..192		4/20 (20%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		LRRCT	204..257	CDD:214507	12/68 (18%)
		Ig	259..364	CDD:299845	26/153 (17%)
		IG_like	266..362	CDD:214653	23/144 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..391		4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010