DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Flrt1

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_958813.1	Gene:	Flrt1 / 396184	MGIID:	3026647	Length:	674	Species:	Mus musculus

Alignment Length:	741	Identity:	168/741 - (22%)
Similarity:	266/741 - (35%)	Gaps:	211/741 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TATTRSRPW--LCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQ 70
            |||...|.|  ||..    |:..||.||  ..||  |||.|:|    .|....|.|..|..:|..
Mouse    26 TATMDLRDWLFLCYG----LIAFLTEVI--DSTT--CPSVCRC----DNGFIYCNDRGLTSIPSD 78

  Fly    71 LNPETKYINLTVNRIRT--LEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVS 133
            :..:...:.|..|:|..  :...|...:|::::.|.:|.::..            .:||.|:| .
Mouse    79 IPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDLDEF------------PINLPRSL-R 130

  Fly   134 SLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNI--VSLEDNCFKGMNTLEV 196
            .||              |..|.:.|:...:|:.:..|.:|.|.:|::  ||:|::.|.....|::
Mouse   131 ELH--------------LQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKL 181

  Fly   197 LVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFE 261
            |....|.|..:| |.|.|.                       |:|   |.:..|.:|.:.|.||:
Mouse   182 LFLSRNHLSSIP-SGLPHT-----------------------LEE---LRLDDNRISTIPLHAFK 219

  Fly   262 GLISLKHLDLSDNNLT--MVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDF 324
            ||.||:.|.|..|.|.  .:.....|:|.|||.|:|..|..:..|    |||
Mouse   220 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPP----LNL------------- 267

  Fly   325 LQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQ 388
                      .:.|||.|:|.:| .:|.||.........:..:.:.:|:|.||....| .:..|.
Mouse   268 ----------PSAHLQKLYLQDN-AISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLA 321

  Fly   389 KLYLGDNPLQCNCSLLWL--W---RLVTGNFEG-VDPGMEHAAGGAVAALAKEADDEELADEATA 447
            :|.|.:||..|.|:|:||  |   |....|..| :..|.|...|.|:..:..|.|:        .
Mouse   322 QLLLRNNPWFCGCNLMWLRDWVRARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDE--------C 378

  Fly   448 VASTDDGVAALAAYIAEQHIVNALHTTEPSA--------------------YELATSSSNRNSGI 492
            ..:...|.||.||  |:..:.|....|.|..                    |.:||....:...|
Mouse   379 FEAGSQGGAANAA--AKTTVSNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLVI 441

  Fly   493 LRMDRQQIGCDIWRDKVRTRRKLL------------------------TMSEGEITCPAHIVTVV 533
                  |:. .:..|.:|...|.:                        |:.:|:.|  .:::|.:
Mouse   442 ------QVK-PLTADSIRITWKAMLPASSFRLSWLRLGHSPAVGSITETLVQGDKT--EYLLTAL 497

  Fly   534 ---CAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGL-GLG 594
               ...|.|::....|.:.:.....|..:.:.....||..|          :.|..|.|.: ||.
Mouse   498 EPKSTYIICMVTMETGNTYVADETPVCAKAETADSYGPTTT----------LNQEQNAGPMAGLP 552

  Fly   595 MSMTLGGGNHVNGLGMTLN----YPHHAQTLQAHHHYHQAMPLQSHGGNGNHEYQQTTL------ 649
            ::..:||...:..|.:.|.    |.|.|..|......:      :.|.....:|.::..
Mouse   553 LAGIIGGAVALVFLFLVLGAICWYVHRAGELLTRERVY------NRGSRRKDDYMESGTKKDNSI 611

  Fly   650 -----PQLDKLELERYLAAQTIANEY 670
                 |.|..|.:..|.:.:    ||
Mouse   612 LEIRGPGLQMLPINPYRSKE----EY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/23 (17%)
		leucine-rich repeat	98..121	CDD:275380	2/22 (9%)
		LRR_8	120..180	CDD:404697	14/59 (24%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	4/22 (18%)
		LRR	<161..>354	CDD:227223	52/196 (27%)
		leucine-rich repeat	170..193	CDD:275380	8/24 (33%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	7/24 (29%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	0/23 (0%)
		LRR_8	337..397	CDD:404697	18/60 (30%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
Flrt1	NP_958813.1	PRK15370	<58..>329	CDD:185268	85/356 (24%)
		leucine-rich repeat	108..128	CDD:275380	4/31 (13%)
		leucine-rich repeat	129..152	CDD:275380	7/37 (19%)
		leucine-rich repeat	153..178	CDD:275380	8/24 (33%)
		leucine-rich repeat	179..199	CDD:275380	7/20 (35%)
		leucine-rich repeat	200..223	CDD:275380	10/25 (40%)
		leucine-rich repeat	224..249	CDD:275380	7/24 (29%)
		leucine-rich repeat	250..271	CDD:275380	9/47 (19%)
		leucine-rich repeat	272..295	CDD:275380	8/23 (35%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		PCC	300..>406	CDD:188093	33/115 (29%)
		FN3	441..505	CDD:214495	9/72 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960