DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and caps

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	887	Identity:	224/887 - (25%)
Similarity:	345/887 - (38%)	Gaps:	225/887 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TRVTATTRS-RPWLCGAIPVLLLLLLTLVI--LPPET-TAFCPSKCQCLGGEANSRALCVDAALE 65
            :|..|.|.| .|.|..|..:.|.|.|.||:  ||... .|.||:.|:|  .:......|.:..|:
  Fly     2 SRRRAITMSLAPHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCEC--DDDTLMVNCGEGTLD 64

  Fly    66 DVPIQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRN 130
            .:||.|||..:.:.:..|:::|::.|:.||.:|..||||.|.:.|:..::|.|.::|:.|:|..|
  Fly    65 VLPIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHN 129

  Fly   131 LVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLE 195
            .:..:....|.||:.:.:|:|..|.|..:.....|.:..|.||:|..|.|..::.:...|::.|.
  Fly   130 KIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLR 194

  Fly   196 VLVFRNNRLLDVPASNLWH-LHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSA 259
            ||...:|.|..||....:. ||:|..|.:..|....:...:|:.||.|..|.::|..:..:...|
  Fly   195 VLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDA 259

  Fly   260 FEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDF 324
            .:||:||:.||||||.|..:||....:|..|..||:|.|.|..:.:.||..|..||.|.|:....
  Fly   260 LKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQR 324

  Fly   325 LQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQK 389
            |:|::|.||..||:|:.|:|::|.||:::......|.|::..|.:::|.|.:|.....|...||.
  Fly   325 LRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQT 389

  Fly   390 LYLGDNPLQCNCSLLWLWR-LVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDD 453
            |.|.:||.:|:|.||||.. ||:.|..|     ::|.  .:.|......|..||..|..:.....
  Fly   390 LDLSENPFECDCRLLWLRHLLVSRNASG-----QYAP--VICAYPTALRDLPLAHLAEPLLGCAH 447

  Fly   454 GVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTM 518
            |.|:..|.|                            |||
  Fly   448 GAASKQAII----------------------------GIL------------------------- 459

  Fly   519 SEGEITCPAHIVTVVCAVITC---LLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHD 580
               .:.|.|.|.|:...:.||   :...:.|.|.|        .||   ||...:|...     :
  Fly   460 ---VVACAALITTLALVLYTCRHRIREMLKGHSAL--------GRK---EREYQKTFSD-----E 505

  Fly   581 RILQGHNPGGLGL-----------GMSMTL---------------------GGGNHVNGLGMTLN 613
            ..:....|||.|:           |.|..:                     ||.:..:|....|.
  Fly   506 EYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGGASTASGAVQQLQ 570

  Fly   614 YP--------------------HHAQTLQAH--------HHYHQAMPLQSHGGNGNHEYQQTTLP 650
            .|                    ::.|..||.        ||..|.|.|.:  .||......|:||
  Fly   571 VPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQDMRLLA--CNGGKPLNATSLP 633

  Fly   651 Q-----LDKLELERYLAAQTIANEYRA---------------------LKPWELPVKEADDEPEH 689
            :     :.:..|..|  :|.:||..|.                     .||.     :|..||.:
  Fly   634 RHRPPVVQESTLSHY--SQPLANGIRLTQDHFNHNQNQSHNQHYGGVYAKPC-----DAMSEPGY 691

  Fly   690 LYERFDHYEYPDTHTMSKLKQAASLNHSNSSAGPSPVPPSSGKP----HVVYVXRGRGTGERVSQ 750
            ::.. .||..|..|.:              ...|:|.||....|    ..:.: .|..||.|...
  Fly   692 IHNN-SHYSLPLDHDL--------------PPSPTPTPPPPALPLRNGVGMALIHGNTTGRRSFN 741

  Fly   751 INTDIEMVGLNHLHLHHHHH---------------NNNNNYR 777
            .|.::..:..|      :||               |||.:.|
  Fly   742 NNNNVSTLSNN------NHHGIGGGVGVAVGGTVGNNNGSLR 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/21 (24%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		LRR_8	120..180	CDD:404697	17/59 (29%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	67/193 (35%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	8/23 (35%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	11/22 (50%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	10/23 (43%)
		LRR_8	337..397	CDD:404697	19/59 (32%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/20 (25%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	15/57 (26%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	83/249 (33%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	20/58 (34%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		LRR_8	265..321	CDD:290566	25/55 (45%)
		leucine-rich repeat	266..289	CDD:275380	11/22 (50%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		LRR_8	312..374	CDD:290566	21/61 (34%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	7/23 (30%)
		LRRCT	395..445	CDD:214507	18/56 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1280
	4	3.920