DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and Toll-7

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	147/563 - (26%)
Similarity:	219/563 - (38%)	Gaps:	152/563 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLCGAIPVLLLLLLTLV---ILPPETTAFCPSKCQCLGGEANSRALCVDAA-------LEDVPIQ 70
            :||   ||..|.:|.|.   |...|...|....|....|.|.|....:||:       .|...|.
  Fly   208 FLC---PVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGIS 269

  Fly    71 LNPETKYINLTVNRIRTLE-FSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSS 134
            .....:::||..|.:..|. .:|.....|.|::||.|.:|||....|....|||.::|.:|.:..
  Fly   270 RLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYE 334

  Fly   135 LHKHAFKGLTNLLLLDLSFNRIETVH--PTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVL 197
            |.|..|..|..||::|||.|::.:.|  .|..:.|..|:.|:|.:|.:..::...||.:..|::|
  Fly   335 LPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQIL 399

  Fly   198 VFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEG 262
            ..|||.:..:..:....|:.|.:|:::.|.:..:.:..|.||..|..|::..|::|.::.:.|:.
  Fly   400 NLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKN 464

  Fly   263 LISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELH--------- 318
            ...||.||||.|.|..|| :.|..|:.|..|:||.|:.......:|.||..|..|.
  Fly   465 CSDLKELDLSSNQLNEVP-RALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNI 528

  Fly   319 -------LSRLDFL-------QRIDSRAFVDNTHLQTLHLNNN-----------------PQLSD 352
                   |.||..|       |.|:..:|..|..|:.:.|:.|                 ..||:
  Fly   529 TVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSE 593

  Fly   353 ----------IPMRL----FQGN-----------------------------------PNILEVY 368
                      ||..|    ..||                                   ||.:|:.
  Fly   594 NHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELL 658

  Fly   369 MQSNSL-----------------QTLYSAQFPVDQLQKL--------------YLGDNPLQCNCS 402
            ..:|:|                 ..||:.|....|||:|              |||.||.:|:|:
  Fly   659 FINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCT 723

  Fly   403 LLWLWR---LVT---------GNFEGVDPGMEHAAGGAVAALA 433
            :.||.|   |.|         .|.|.|   |.||.|.||..|:
  Fly   724 MDWLQRINNLTTRQHPRVMDMANIECV---MPHARGAAVRPLS 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/22 (23%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		LRR_8	120..180	CDD:404697	22/61 (36%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	9/24 (38%)
		LRR	<161..>354	CDD:227223	60/242 (25%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	12/22 (55%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	10/46 (22%)
		LRR_8	337..397	CDD:404697	26/156 (17%)
		leucine-rich repeat	339..360	CDD:275380	8/51 (16%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	16/53 (30%)
		leucine-rich repeat	191..214	CDD:275380	4/8 (50%)
		leucine-rich repeat	215..248	CDD:275380	9/32 (28%)
		LRR_RI	247..501	CDD:238064	77/254 (30%)
		LRR_8	247..308	CDD:290566	15/60 (25%)
		leucine-rich repeat	249..273	CDD:275380	4/23 (17%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		LRR_8	297..356	CDD:290566	24/58 (41%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	8/22 (36%)
		LRR_8	345..406	CDD:290566	20/60 (33%)
		leucine-rich repeat	346..371	CDD:275380	9/24 (38%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		LRR_8	419..478	CDD:290566	18/58 (31%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	5/22 (23%)
		LRR_RI	466..622	CDD:238064	40/156 (26%)
		leucine-rich repeat	468..488	CDD:275380	11/20 (55%)
		LRR_8	491..549	CDD:290566	14/57 (25%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	2/20 (10%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	3/21 (14%)
		leucine-rich repeat	586..626	CDD:275380	7/39 (18%)
		leucine-rich repeat	627..653	CDD:275380	0/25 (0%)
		LRRCT	716..772	CDD:214507	19/51 (37%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010