DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and lbk

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	138/517 - (26%)
Similarity:	228/517 - (44%)	Gaps:	73/517 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVPI-------------QLNPET-----KYINLT-VNRIRT 87
            ||..|:||    |....|....||.||:             :||..|     ..:||| |:..|.
  Fly   265 CPKDCKCL----NVLFDCDKLHLERVPVLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRN 325

  Fly    88 LEFSLPFYM---KLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLL 149
            |...:|.::   .|:.|.|:.|.|.::.|::......||||:||||.:.::..::|....||:.|
  Fly   326 LLEVIPKFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHL 390

  Fly   150 DLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRL---------- 204
            .||||.|..|:..:.:.|.:|.:|:|:||.:.:|....||.:|.|:.|....|:|
  Fly   391 ILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLEINWSTFRGL 455

  Fly   205 -----LDVPASNL--------WHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELD 256
                 |.:.::.:        :.:|.::::|:::|.:..:.......|.:|..|::..|.:|.::
  Fly   456 ESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIE 520

  Fly   257 LSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHL-- 319
            :..:|...||:.||||:|.:.....|.|..|..|..|||..||...|....|..:.:|.||:|
  Fly   521 VDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELNLRR 585

  Fly   320 SRLDFLQRIDSRA--FVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF 382
            :||.::....|.|  |.....|:.|.|:.| .|..|..:...|..|:..:.:.||:|.::....|
  Fly   586 NRLSWIIEDQSAAAPFKGLRKLRRLDLHGN-NLKQISTKAMSGLNNLEILNLGSNALASIQVNAF 649

  Fly   383 P-VDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAAL----AKEADDEEL- 441
            . :.:|.||........|:|.|:|..:.:...|   ....|||..|....|    .|.....||
  Fly   650 EHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRF---PQQAEHAVCGYPEHLLDRHLKSLSSSELV 711

  Fly   442 ---ADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQQI 500
               :.:.......||.:|..||.|..:.|.::     |:|..||.:...:..  .|.|.|.:
  Fly   712 CVDSPKPRVEQEPDDMLAVNAANITLECIASS-----PTAASLAAADELKIK--WRHDNQHV 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	8/30 (27%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	24/59 (41%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	56/219 (26%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	5/45 (11%)
		leucine-rich repeat	218..265	CDD:275380	8/46 (17%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	9/27 (33%)
		LRR_8	337..397	CDD:404697	15/60 (25%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	52/170 (31%)
		leucine-rich repeat	293..316	CDD:275380	3/22 (14%)
		LRR_8	316..373	CDD:290566	21/56 (38%)
		leucine-rich repeat	317..338	CDD:275380	6/20 (30%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		leucine-rich repeat	363..386	CDD:275380	9/22 (41%)
		LRR_8	386..445	CDD:290566	22/58 (38%)
		leucine-rich repeat	387..410	CDD:275380	9/22 (41%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..457	CDD:275380	4/21 (19%)
		LRR_8	457..516	CDD:290566	8/58 (14%)
		leucine-rich repeat	458..481	CDD:275380	1/22 (5%)
		leucine-rich repeat	482..505	CDD:275380	3/22 (14%)
		LRR_RI	<498..669	CDD:238064	49/171 (29%)
		LRR_8	504..564	CDD:290566	20/59 (34%)
		leucine-rich repeat	506..529	CDD:275380	5/22 (23%)
		leucine-rich repeat	530..553	CDD:275380	9/22 (41%)
		leucine-rich repeat	554..577	CDD:275380	8/22 (36%)
		LRR_8	576..641	CDD:290566	19/65 (29%)
		leucine-rich repeat	578..604	CDD:275380	9/25 (36%)
		leucine-rich repeat	607..630	CDD:275380	7/23 (30%)
		leucine-rich repeat	631..652	CDD:275380	4/20 (20%)
		LRRCT	665..712	CDD:214507	13/49 (27%)
		IG	734..823	CDD:214652	9/40 (23%)
		Ig	735..823	CDD:143165	9/39 (23%)
		I-set	834..924	CDD:254352
		Ig	851..924	CDD:299845
		IG	936..1027	CDD:214652
		Ig	961..1020	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010