Protein Alignment Fili and IGFALS

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001139478.1
• Gene: IGFALS / 3483
• HGNCID: 5468
• Length: 643
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 113/380 - (29%)
• Similarity: 178/380 - (46%)
• Gaps: 45/380 - (11%)

  Fly    54 NSRALCVDAA------LEDVPI------QLNP-------ETKYINLTVNRIRTLE----FSLPFY 95
            ||.|:..|||      |.::.:      .|.|       |.:.::|:.|.:|.::    ..||
Human   218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP-- 280

  Fly    96 MKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVH 160
             :|:.|.|.:|:|..:....|.....||.|:||.|.|:.|.:..|.||..|.:|.||.|.|.::.
Human   281 -RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 344

  Fly   161 PTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSL 225
            |....||..|.||.|.:|.|..|.:..|:|:..||||...:|:|.:|.|.....|..:..:::|.
Human   345 PRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSG 409

  Fly   226 NLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNL 290
            |.:..:....|.||.:|.:|.::|:.:..:....|.||..|:.|.|.||.|..:..|.|..|:.|
Human   410 NCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAEL 474

  Fly   291 TYLNLGGNRFSQLPAVAFLNLFHLRELHLSR-------LDFLQRIDSRAFVDNTHLQTLHLNNNP 348
            ..|:|..|:.:.||...|..|..|..|.|||       .|.|..:....::|.:|         .
Human   475 LELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSH---------N 530

  Fly   349 QLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSL 403
            :|..:|..|......:..:.:::|||:| ::.|.|  .|::|:|..||..|.|.|
Human   531 RLEALPNSLLAPLGRLRYLSLRNNSLRT-FTPQPP--GLERLWLEGNPWDCGCPL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	89/294 (30%)
		leucine-rich repeat	75..97	CDD:275378	5/25 (20%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	8/30 (27%)
		LRR_8	337..397	CDD:404697	14/59 (24%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470
		leucine-rich repeat	95..113	CDD:275380
		leucine-rich repeat	114..137	CDD:275380
		LRR	132..574	CDD:443914	108/370 (29%)
		leucine-rich repeat	138..161	CDD:275380
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380	6/14 (43%)
		leucine-rich repeat	234..257	CDD:275380	3/22 (14%)
		leucine-rich repeat	258..281	CDD:275380	5/25 (20%)
		leucine-rich repeat	282..305	CDD:275380	6/22 (27%)
		leucine-rich repeat	306..324	CDD:275380	8/17 (47%)
		leucine-rich repeat	354..377	CDD:275380	9/22 (41%)
		leucine-rich repeat	378..401	CDD:275380	9/22 (41%)
		leucine-rich repeat	402..423	CDD:275380	3/20 (15%)
		leucine-rich repeat	426..447	CDD:275380	4/20 (20%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	8/22 (36%)
		leucine-rich repeat	498..519	CDD:275380	7/20 (35%)
		leucine-rich repeat	522..543	CDD:275380	5/29 (17%)
		leucine-rich repeat	546..565	CDD:275380	6/21 (29%)
		LRRCT	574..618	CDD:214507	5/9 (56%)