DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and IGFALS

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001139478.1	Gene:	IGFALS / 3483	HGNCID:	5468	Length:	643	Species:	Homo sapiens

Alignment Length:	380	Identity:	113/380 - (29%)
Similarity:	178/380 - (46%)	Gaps:	45/380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NSRALCVDAA------LEDVPI------QLNP-------ETKYINLTVNRIRTLE----FSLPFY 95
            ||.|:..|||      |.::.:      .|.|       |.:.::|:.|.:|.::    ..||
Human   218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP-- 280

  Fly    96 MKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVH 160
             :|:.|.|.:|:|..:....|.....||.|:||.|.|:.|.:..|.||..|.:|.||.|.|.::.
Human   281 -RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 344

  Fly   161 PTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSL 225
            |....||..|.||.|.:|.|..|.:..|:|:..||||...:|:|.:|.|.....|..:..:::|.
Human   345 PRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSG 409

  Fly   226 NLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNL 290
            |.:..:....|.||.:|.:|.::|:.:..:....|.||..|:.|.|.||.|..:..|.|..|:.|
Human   410 NCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAEL 474

  Fly   291 TYLNLGGNRFSQLPAVAFLNLFHLRELHLSR-------LDFLQRIDSRAFVDNTHLQTLHLNNNP 348
            ..|:|..|:.:.||...|..|..|..|.|||       .|.|..:....::|.:|         .
Human   475 LELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSH---------N 530

  Fly   349 QLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSL 403
            :|..:|..|......:..:.:::|||:| ::.|.|  .|::|:|..||..|.|.|
Human   531 RLEALPNSLLAPLGRLRYLSLRNNSLRT-FTPQPP--GLERLWLEGNPWDCGCPL 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/25 (20%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	25/59 (42%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	59/199 (30%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	8/30 (27%)
		LRR_8	337..397	CDD:404697	14/59 (24%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470
		leucine-rich repeat	95..113	CDD:275380
		leucine-rich repeat	114..137	CDD:275380
		leucine-rich repeat	138..161	CDD:275380
		LRR_8	141..196	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		LRR_8	184..244	CDD:290566	7/25 (28%)
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380	6/14 (43%)
		leucine-rich repeat	234..257	CDD:275380	3/22 (14%)
		LRR_8	257..316	CDD:290566	18/61 (30%)
		leucine-rich repeat	258..281	CDD:275380	5/25 (20%)
		leucine-rich repeat	282..305	CDD:275380	6/22 (27%)
		leucine-rich repeat	306..324	CDD:275380	8/17 (47%)
		LRR_8	336..388	CDD:290566	20/51 (39%)
		leucine-rich repeat	354..377	CDD:275380	9/22 (41%)
		LRR_8	377..433	CDD:290566	16/55 (29%)
		leucine-rich repeat	378..401	CDD:275380	9/22 (41%)
		leucine-rich repeat	402..423	CDD:275380	3/20 (15%)
		LRR_8	425..484	CDD:290566	19/58 (33%)
		leucine-rich repeat	426..447	CDD:275380	4/20 (20%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	8/22 (36%)
		LRR_8	476..532	CDD:290566	16/64 (25%)
		leucine-rich repeat	498..519	CDD:275380	7/20 (35%)
		leucine-rich repeat	522..543	CDD:275380	5/29 (17%)
		LRR_8	524..575	CDD:290566	14/62 (23%)
		leucine-rich repeat	546..565	CDD:275380	6/21 (29%)
		TPKR_C2	574..618	CDD:301599	5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010