DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Rtn4rl2

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_852045.1	Gene:	Rtn4rl2 / 311169	RGDID:	727797	Length:	420	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	101/396 - (25%)
Similarity:	142/396 - (35%)	Gaps:	142/396 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGG------EANSRALCVDAALEDVPIQLNPETKYINL 80
            |....|||||:.|||.|.: ||..|.|...      :||:        ...||:.|.|.|
  Rat    12 PASACLLLTLLALPPVTPS-CPMLCTCYSSPPTVSCQANN--------FSSVPLSLPPST----- 62

  Fly    81 TVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTN 145
                                                      :.|.|..||:.||....|.  .|
  Rat    63 ------------------------------------------QRLFLQNNLIRSLRPGTFG--PN 83

  Fly   146 LLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPAS 210
            ||.|.|..|.:.|::|.....|.:|.||||.:|.
  Rat    84 LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR------------------------------- 117

  Fly   211 NLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNN 275
               ||.:|:.             |:|:||:.|.:|.:....:|.|..:.|.||:||::|.|.:|:
  Rat   118 ---HLRSLEP-------------DTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENS 166

  Fly   276 LTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE--LHLSRLDFLQRIDSRAFVDNTH 338
            |..:.....:.|:||::|.|.|||...|....|..|..|..  ||.:|   ||.:...||...:.
  Rat   167 LLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNR---LQGVHRAAFHGLSR 228

  Fly   339 LQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSL 403
            |..|:|.|| .|:.:|                ..:|..|.:.:|       |.|..||..|:|..
  Rat   229 LTILYLFNN-SLASLP----------------GEALADLPALEF-------LRLNANPWACDCRA 269

  Fly   404 --LWLW 407
              ||.|
  Rat   270 RPLWAW 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	1/21 (5%)
		leucine-rich repeat	98..121	CDD:275380	0/22 (0%)
		LRR_8	120..180	CDD:404697	22/59 (37%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	53/194 (27%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	2/22 (9%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	8/25 (32%)
		LRR_8	337..397	CDD:404697	13/59 (22%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
Rtn4rl2	NP_852045.1	LRR_8	60..117	CDD:290566	23/105 (22%)
		LRR 1	61..82		8/69 (12%)
		leucine-rich repeat	62..83	CDD:275380	8/69 (12%)
		LRR 2	83..104		8/20 (40%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		LRR_RI	103..>261	CDD:238064	58/231 (25%)
		LRR 3	107..129		11/68 (16%)
		LRR_8	108..167	CDD:290566	25/105 (24%)
		leucine-rich repeat	108..132	CDD:275380	13/70 (19%)
		LRR 4	132..153		5/20 (25%)
		leucine-rich repeat	133..156	CDD:275380	7/22 (32%)
		LRR_8	156..215	CDD:290566	21/61 (34%)
		LRR 5	156..177		6/20 (30%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		LRR 6	180..201		9/20 (45%)
		leucine-rich repeat	181..204	CDD:275380	9/22 (41%)
		LRR_8	204..262	CDD:290566	20/84 (24%)
		LRR 7	204..225		8/23 (35%)
		leucine-rich repeat	205..228	CDD:275380	8/25 (32%)
		LRR 8	228..249		8/37 (22%)
		leucine-rich repeat	229..252	CDD:275380	9/39 (23%)
		TPKR_C2	261..311	CDD:301599	7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..390
		Important for interaction with MAG. /evidence=ECO:0000269\|PubMed:19420245	315..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100