Protein Alignment Fili and Nepn

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001401899.1
• Gene: Nepn / 309775
• RGDID: 1307755
• Length: 512
• Species: Rattus norvegicus
• Alignment Length: 513
• Identity: 130/513 - (25%)
• Similarity: 207/513 - (40%)
• Gaps: 145/513 - (28%)

  Fly    24 LLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTL 88
            ||.|.|:.|:     .|.||.:|.|   ::.....|.  .|.:||..:...|:.:.::.:||:.|
  Rat     8 LLWLSLSNVL-----GANCPGRCSC---DSLQSVQCY--RLLEVPSGIPSTTRRLYISHSRIQHL 62

  Fly    89 EFS-LPFYMKLEILDLSQNIIETLGSKNFEYQSELRT---------------------LNLSRNL 131
            :.| |...:.||...|..:..|::.:..|:..:.|:|                     |.|:.|.
  Rat    63 QLSNLTQLLALEDFILLASGTESIENDTFKTLTTLKTLELWKNKLRRVPSALPANLEVLKLNDNS 127

  Fly   132 VSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEV 196
            :.:||...|:||:||.:|:|..|.|.::.|:.||.|.||..|.:..|||.|:..
  Rat   128 ICALHGSDFEGLSNLKVLELKNNLISSLSPSMLSSLVSLQSLLVDGNNIESVTG----------- 181

  Fly   197 LVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFE 261
                       |.|    |..||.:.|..|.:..:..:.|..|:.|..||..||.::::.::..:
  Rat   182 -----------PLS----LPNLKYMSMEKNKLHLISGNVFTSLQNLQFLSFSGNFLTKIPINLPK 231

  Fly   262 GLISLK---------------------HLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPA 305
            .|:|||                     ||.||:|.|:.:...||  |:|||.|....||...||.
  Rat   232 SLLSLKMERNQLKVVRFRDMRHLENLSHLYLSENLLSSIDGAQL--LTNLTTLEASQNRLQMLPP 294

  Fly   306 VAFLNLFHLRELHLSRLD----FLQRIDSRAFVDNTHLQTLHLNNN-------------PQLSD- 352
                    .....|.:||    |:||:.:..|.|...|:.|.|:||             .|||:
  Rat   295 --------RLPSRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVSLFEAGALQKCSQLSNL 351

  Fly   353 ---------IPMRL--------FQGN-------------PNILEVYMQSNSLQTL-YSAQFPVDQ 386
                     ||:||        .:||             ..:..:.:::|.:..| ..|...:.:
  Rat   352 ALEQNLLLSIPLRLPKTLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNKISALDLKALEGLPR 416

  Fly   387 LQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADE 444
            |:.|||..||..|.||||....::..  :|.|     ..||..||.|:...:..::.:
  Rat   417 LRHLYLDGNPWNCTCSLLRAREVLKA--KGTD-----VKGGQCAAPAERQGESWMSSK 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	86/336 (26%)
		leucine-rich repeat	75..97	CDD:275378	6/22 (27%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		leucine-rich repeat	122..145	CDD:275380	10/43 (23%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	3/22 (14%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	11/43 (26%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	8/27 (30%)
		LRR_8	337..397	CDD:404697	22/104 (21%)
		leucine-rich repeat	339..360	CDD:275380	12/51 (24%)
Nepn	NP_001401899.1	leucine-rich repeat	50..72	CDD:275380	5/21 (24%)
		leucine-rich repeat	73..96	CDD:275380	5/22 (23%)
		LRR	112..>428	CDD:443914	91/351 (26%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		leucine-rich repeat	166..187	CDD:275380	9/46 (20%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	236..256	CDD:275380	2/19 (11%)
		leucine-rich repeat	257..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..299	CDD:275380	7/27 (26%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	324..347	CDD:275380	5/22 (23%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		leucine-rich repeat	372..392	CDD:275380	2/19 (11%)
		leucine-rich repeat	393..416	CDD:275380	3/22 (14%)