DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Lrfn3

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001100972.1	Gene:	Lrfn3 / 308495	RGDID:	1305567	Length:	626	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	128/550 - (23%)
Similarity:	178/550 - (32%)	Gaps:	215/550 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLLLLLLTLVILP------PETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLT 81
            ||.|||..|.:.|      |.|::.||.:|:|.........||..|.|..||..|:...
  Rat     3 VLPLLLCLLPLAPASSPPQPATSSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRA------ 61

  Fly    82 VNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNL 146
                                                  :|||   |:.|.::::.:.....:|.|
  Rat    62 --------------------------------------AELR---LADNFIAAVRRRDLANMTGL 85

  Fly   147 LLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASN 211
            |.|.||.|.|..|...|.:||.:|..|.|..|.:.||.:...:|:..|..|:..||:|..:.|..
  Rat    86 LHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGA 150

  Fly   212 LWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNL 276
            |                    :|..|                           :|:.||||.|||
  Rat   151 L--------------------DDCAE---------------------------TLEDLDLSYNNL 168

  Fly   277 TMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQT 341
            ..:|.:.|.:|.|:..|.|..|..:.:||.||           |||..|.|:|    :.:..|.|
  Rat   169 EQLPWEALGRLGNVNTLGLDHNLLASVPAGAF-----------SRLHKLARLD----MTSNRLTT 218

  Fly   342 LHLNNNPQLSDIPMRLF-QGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLW 405
              :..:|..|.:|:... :|:|....|                      |..|.|||.|||.|:|
  Rat   219 --IPPDPLFSRLPLLARPRGSPASALV----------------------LAFGGNPLHCNCELVW 259

  Fly   406 LWRL---------------------VTGNFEGV---------DPGMEHAAGGAVAALAKEADDEE 440
            |.||                     ..|..|.|         .|.:...||...|...:...|.|
  Rat   260 LRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPE 324

  Fly   441 ------------LADEATA-----------VASTDDG-----VAALAAYIAEQHIVNALHTTEPS 477
                        |.:.:.|           |...:||     :||.||  .|......|....|.
  Rat   325 PRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPEDGGTFTCIAANAA--GEATAAVELTVGPPP 387

  Fly   478 AYELATSSSNRNSGILRMDRQQIGCDIWRD 507
            ..:||.|:|               ||..||
  Rat   388 PPQLANSTS---------------CDPPRD 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	0/21 (0%)
		leucine-rich repeat	98..121	CDD:275380	0/22 (0%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	4/22 (18%)
		leucine-rich repeat	146..169	CDD:275380	11/22 (50%)
		LRR	<161..>354	CDD:227223	48/192 (25%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	2/46 (4%)
		leucine-rich repeat	266..289	CDD:275380	11/22 (50%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	11/60 (18%)
		leucine-rich repeat	339..360	CDD:275380	5/21 (24%)
Lrfn3	NP_001100972.1	LRR	<63..>222	CDD:227223	60/225 (27%)
		leucine-rich repeat	63..84	CDD:275380	5/23 (22%)
		LRR 1	84..105		9/20 (45%)
		leucine-rich repeat	85..108	CDD:275380	11/22 (50%)
		LRR 2	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR 3	132..153		7/40 (18%)
		leucine-rich repeat	133..157	CDD:275380	9/70 (13%)
		LRR 4	157..178		10/20 (50%)
		leucine-rich repeat	158..181	CDD:275380	11/22 (50%)
		LRR 5	181..202		8/31 (26%)
		leucine-rich repeat	182..205	CDD:275380	10/33 (30%)
		LRR 6	205..226		6/26 (23%)
		leucine-rich repeat	206..230	CDD:275380	7/29 (24%)
		leucine-rich repeat	242..253	CDD:275378	6/32 (19%)
		TPKR_C2	249..>281	CDD:417692	11/31 (35%)
		Ig	296..383	CDD:416386	17/88 (19%)
		Ig strand A	296..299	CDD:409353	0/2 (0%)
		Ig strand A'	303..306	CDD:409353	1/2 (50%)
		Ig strand B	312..320	CDD:409353	1/7 (14%)
		Ig strand C	326..331	CDD:409353	0/4 (0%)
		Ig strand C'	334..336	CDD:409353	0/1 (0%)
		Ig strand D	342..346	CDD:409353	1/3 (33%)
		Ig strand E	349..353	CDD:409353	0/3 (0%)
		Ig strand F	363..370	CDD:409353	1/6 (17%)
		Ig strand G	373..383	CDD:409353	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..423		8/35 (23%)
		fn3	425..502	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000