DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Cpn2

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001100555.1	Gene:	Cpn2 / 303861	RGDID:	1305170	Length:	565	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	135/534 - (25%)
Similarity:	209/534 - (39%)	Gaps:	121/534 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINL 80
            |||.|    .||||..|..|      ||..|.|.    :.:..|.|..|..:|:.:...
  Rat    29 WLCWA----SLLLLVRVTQP------CPVGCDCF----DRKIFCSDEQLAAIPLDIPSH------ 73

  Fly    81 TVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTN 145
             |..|..:|.|                ..|:|::.|.....|..:......|..|...||.||..
  Rat    74 -VTDIVFVETS----------------FTTVGTRAFSGSPNLTKVVFLNTRVHHLEPDAFGGLPR 121

  Fly   146 LLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPAS 210
            |..|:::.:....:.....|:|:||.:|.|..|.:.:|.::.|..|:|||.|..:.|:|..:|..
  Rat   122 LEDLEVTGSPFSNLSANIFSNLSSLGKLTLDFNRLAALPEDLFHHMDTLESLQLQGNQLQTLPGR 186

  Fly   211 NLWHLHALKSLDMSLNLVEFVRNDSFEGLK--ELLALS----------------------VQGNV 251
            ....|..|::|:::.||:..:....|:.|.  ::|.||                      :..|.
  Rat   187 LFQSLRYLRTLNLAQNLLTQLPKGMFQSLSSLQILKLSDNMFARLPEGVLSNLGSLQELFLDSNA 251

  Fly   252 MSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE 316
            ::||....|..|:||:.|.|..|.::.:|....|.|.|||:|||..|....|||..|.:...|..
  Rat   252 ITELSPHLFSHLLSLEKLWLQHNAISHLPVSAFSSLRNLTFLNLKDNALRTLPAGLFTHNPGLLH 316

  Fly   317 LHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQ 381
            |.|| .:.|:.:...:|.:...|.:|.|::| .::.:|..:|:....::::.:.||:|..|:...
  Rat   317 LSLS-YNQLETVPEGSFANLRKLASLTLSHN-AITHLPENVFRNLEQLVKLSLDSNNLTVLHPTL 379

  Fly   382 FPVDQLQKLYLGD---------------------------NPLQCNCSLLWL--W-RLVTG---N 413
            |  ..|.||.|.|                           ||.||:|.|.:|  | ||...   |
  Rat   380 F--HNLSKLQLLDLSRNQLTMLPGGIFDTNYDLFNLALLGNPWQCDCRLSYLTSWLRLYNDRIFN 442

  Fly   414 FEGVDPGMEHAAGGAVAALAKE------------ADDEE------LADEATA-----VASTDDGV 455
            ......|..:..|..|..|.:|            .||.|      ||.|..|     :....:|.
  Rat   443 THTFCAGPAYLKGQLVPNLKQEQLVCPGNPGQLGLDDREPAGSWDLAVEGRAAHRQCIYGNPEGT 507

  Fly   456 AALAAYIAEQHIVN 469
            ..||...|:...:|
  Rat   508 VLLACEEAQCRWLN 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	3/22 (14%)
		LRR_8	120..180	CDD:404697	16/59 (27%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	4/22 (18%)
		LRR	<161..>354	CDD:227223	61/216 (28%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	14/70 (20%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	17/86 (20%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
Cpn2	NP_001100555.1	LRRNT	44..75	CDD:214470	9/47 (19%)
		leucine-rich repeat	77..97	CDD:275380	6/35 (17%)
		LRR_8	96..156	CDD:290566	16/59 (27%)
		leucine-rich repeat	122..145	CDD:275380	4/22 (18%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR_8	169..226	CDD:290566	17/56 (30%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		LRR_RI	172..418	CDD:238064	60/249 (24%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		LRR_8	241..300	CDD:290566	20/58 (34%)
		leucine-rich repeat	242..265	CDD:275380	5/22 (23%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		LRR_8	288..348	CDD:290566	21/61 (34%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		leucine-rich repeat	314..337	CDD:275380	6/23 (26%)
		LRR_8	336..396	CDD:290566	16/62 (26%)
		leucine-rich repeat	338..361	CDD:275380	6/23 (26%)
		leucine-rich repeat	362..383	CDD:275380	5/22 (23%)
		leucine-rich repeat	386..405	CDD:275380	3/18 (17%)
		LRRCT	418..459	CDD:214507	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020