DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and Nyx

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001094437.1	Gene:	Nyx / 302516	RGDID:	1561300	Length:	476	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	141/549 - (25%)
Similarity:	225/549 - (40%)	Gaps:	98/549 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLLLLLLTLVILPPETTA------FCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLT 81
            :|.|||..:|...|.|.|      .||:.|.|...|......|..|.|:.||.:
  Rat     1 MLNLLLYAVVFSLPCTRATEACLRACPAACTCSNVERGCSVRCDRAGLQRVPTE----------- 54

  Fly    82 VNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNL 146
                        |..:...:||.:|.:..||.:.|.....||.|:|..|.:|.:...|||||..|
  Rat    55 ------------FPCEAASIDLDRNGLRILGERAFGTLPSLRCLSLRHNNLSFITPGAFKGLPRL 107

  Fly   147 LLLDLSFN-RIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPA- 209
            ..|.|:.| .:..:|....:.|..|..|||....:.|:.:.....:..|..|...:|....||.
  Rat   108 AELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPERLLAELPALRELTAFDNLFRRVPGA 172

  Fly   210 ----SNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLD 270
                :||.|.|..:|      .:|.|.:.|..|::.|.:||:|.|.:..:...||...::|:||.
  Rat   173 LRGLANLTHAHFERS------RIEAVASSSLLGMRRLRSLSLQANRVRAVHAGAFGDCVALEHLL 231

  Fly   271 LSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335
            |:||.|..:|......|..|..||||||....:....|.:|..|..|:|.| :.:..::..||.:
  Rat   232 LNDNLLASLPAAAFRGLRRLRTLNLGGNALGSVARGWFSDLAELELLYLDR-NSITFVEEGAFQN 295

  Fly   336 NTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCN 400
            .:.|..||||.| :|:.:....||                       |...|.:|:|..||.:|:
  Rat   296 LSGLLALHLNGN-RLTVLSWAAFQ-----------------------PGFFLGRLFLFRNPWRCD 336

  Fly   401 CSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQ 465
            |.|.||...:.|:....|  :..|:.|:||.       ::|:.  .....:.||:.     :...
  Rat   337 CHLEWLRDWMEGSGRVAD--VACASPGSVAG-------QDLSQ--VVFERSSDGIC-----VDPD 385

  Fly   466 HIVNALHTTEPSAYELATSSSNRNSGIL------RMDRQQIGCDIWRDKVRTRRKLLTMSEGEIT 524
            .:.....:..||...:||:.| |.|.:|      |...:::....|        :|:.:|..: :
  Rat   386 ELNFTTFSPGPSPEPVATTVS-RFSSLLSKLLAPRAPVEEVANTTW--------ELVNVSLND-S 440

  Fly   525 CPAHIVTVVCAVITCLLVAMIGISVLYYL 553
            ..:|.|.|:|...|.|..:.:.:|:..|:
  Rat   441 FRSHGVMVMCYKATFLFTSCLWLSLAQYV 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	1/21 (5%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	21/60 (35%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	6/23 (26%)
		LRR	<161..>354	CDD:227223	58/197 (29%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	8/27 (30%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	14/59 (24%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
Nyx	NP_001094437.1	LRRNT	25..56	CDD:214470	10/53 (19%)
		leucine-rich repeat	63..82	CDD:275380	6/18 (33%)
		LRR_RI	<68..312	CDD:238064	77/251 (31%)
		LRR_8	81..142	CDD:290566	21/60 (35%)
		leucine-rich repeat	83..106	CDD:275380	11/22 (50%)
		leucine-rich repeat	107..131	CDD:275380	6/23 (26%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..178	CDD:275380	5/21 (24%)
		leucine-rich repeat	179..202	CDD:275380	8/28 (29%)
		LRR_8	201..261	CDD:290566	23/59 (39%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		leucine-rich repeat	227..250	CDD:275380	9/22 (41%)
		LRR_8	249..309	CDD:290566	21/61 (34%)
		leucine-rich repeat	251..274	CDD:275380	9/22 (41%)
		leucine-rich repeat	275..296	CDD:275380	6/21 (29%)
		leucine-rich repeat	299..318	CDD:275380	7/19 (37%)
		LRRCT	331..>366	CDD:214507	13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010