DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and Lrrc66

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001008763.1 Gene:Lrrc66 / 289587 RGDID:1306094 Length:865 Species:Rattus norvegicus


Alignment Length:280 Identity:70/280 - (25%)
Similarity:110/280 - (39%) Gaps:71/280 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 LDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNC-----------------FKGMN-TLE 195
            ||.:.:|:..|..:.|:.|.:|..|:|.::.|.||   |                 |:|.: .|:
  Rat    79 LDRTNHRLSKVTLSCLAHLRALEMLNLGDDVIHSL---CLDLSLPSSSRQKRHRSRFRGRHPRLK 140

  Fly   196 VLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAF 260
            ||:.:.|:|...| ..||.|..|.|||:|.|....:....|.|..:|.::.::.|.:..:...||
  Rat   141 VLLLQRNQLGPTP-KGLWKLKPLCSLDLSFNRRVGIGLSGFHGCLQLKSIYLKNNKILTIHPEAF 204

  Fly   261 EGLISLKHLDLSDNNLTMV----------PTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHL- 314
            :||..|:.:||..:.|||:          |..:|....|....|.....|..:.:|::..::.. 
  Rat   205 KGLKKLQVVDLRSSALTMLVPIVTIALEWPNLELGLADNQWQCNESDANFQNIASVSWGEIWKAV 269

  Fly   315 --------------------RELHLSR---LDFLQRIDS-----RAFVDNTHLQTLHLNNNPQLS 351
                                |::||.|   .|....|.|     ||.:| .||..|.........
  Rat   270 CNTPVENEKPYVEASQIRISRDIHLPRSPSSDLQSLIQSKAEKPRAGMD-VHLSALEKKAQVGYG 333

  Fly   352 DI-------PMRL--FQGNP 362
            |:       ||.|  .||.|
  Rat   334 DLKGIWLQSPMELRDSQGGP 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378
leucine-rich repeat 98..121 CDD:275380
LRR_8 120..180 CDD:404697 9/30 (30%)
leucine-rich repeat 122..145 CDD:275380
leucine-rich repeat 146..169 CDD:275380 6/19 (32%)
LRR <161..>354 CDD:227223 60/256 (23%)
leucine-rich repeat 170..193 CDD:275380 9/40 (23%)
leucine-rich repeat 194..217 CDD:275380 9/22 (41%)
leucine-rich repeat 218..265 CDD:275380 14/46 (30%)
leucine-rich repeat 266..289 CDD:275380 8/32 (25%)
leucine-rich repeat 290..313 CDD:275380 3/22 (14%)
leucine-rich repeat 314..338 CDD:275380 10/52 (19%)
LRR_8 337..397 CDD:404697 10/35 (29%)
leucine-rich repeat 339..360 CDD:275380 6/29 (21%)
Lrrc66NP_001008763.1 leucine-rich repeat 78..99 CDD:275380 6/19 (32%)
LRR_RI <135..>243 CDD:238064 31/108 (29%)
LRR 1 138..160 8/22 (36%)
leucine-rich repeat 139..161 CDD:275380 9/22 (41%)
LRR 2 161..182 7/20 (35%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 164..220 CDD:290566 16/55 (29%)
LRR 3 185..206 4/20 (20%)
leucine-rich repeat 186..209 CDD:275380 6/22 (27%)
LRR 4 209..230 6/20 (30%)
leucine-rich repeat 210..235 CDD:275380 6/24 (25%)
LRR 5 235..255 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..522
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..749
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 840..865
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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