DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fili and Lrrn2

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001170839.1	Gene:	Lrrn2 / 289020	RGDID:	1305482	Length:	750	Species:	Rattus norvegicus

Alignment Length:	682	Identity:	162/682 - (23%)
Similarity:	258/682 - (37%)	Gaps:	166/682 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CPSKCQC----------LGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLE-FSLPFY 95
            ||.:|.|          ...||.: ..|.|..|..||..|...|:.:.|..|.|..:| ..|.:.
  Rat    29 CPPQCACQIRPWYTPRSSYREATT-VDCNDLFLTAVPPGLPAGTQTLLLQSNSISRIEQTELGYL 92

  Fly    96 MKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVH 160
            ..|..||||||........:|:...:|.:|:|..|.:|.|..|:|.|||.|..|.|:.|::..:.
  Rat    93 ANLTELDLSQNSFSDARDCDFQALPQLLSLHLEENQLSRLEDHSFAGLTRLQELYLNHNQLCRIS 157

  Fly   161 PTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSL 225
            |.|...|.:|:.|.|.:|.:.:::...|:.:..||:|:...|::..:             |||
  Rat   158 PRAFEGLGNLLRLHLNSNLLRTIDSRWFEMLPNLEILMIGGNKVDAI-------------LDM-- 207

  Fly   226 NLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNL 290
                     :|..|..|.:|.:.|..:.|:...|.|||.||:.|...||.|..||.:.|.::..|
  Rat   208 ---------NFRPLANLRSLVLAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGL 263

  Fly   291 TYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPM 355
            .:|:|..|...::....|.|:.||:||.|:.::.|..||..|.|:...|..|.:.|||:||.|..
  Rat   264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328

  Fly   356 RLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEG--- 416
            |.|...|.:..:.:.:|:|..|:.... .:..||::.|..||::|:|.:.|      .|..|
  Rat   329 RAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRW------ANATGTHV 387

  Fly   417 --VDPGMEHAAGGAVAALAKEADD-----------EELADEATAVASTDDGVAALAAYIAEQHIV 468
              ::|         .:.|..|..|           .|:.|....:.|.....::|.....|..::
  Rat   388 RFIEP---------QSTLCAEPPDLQRRPVREVPFREMTDHCLPLISPRSFPSSLQVASGESLVL 443

  Fly   469 N--ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVT 531
            :  ||...||..|.:..:.       :|:           ...|:.||.....||.:.. ..:..
  Rat   444 HCRALAEPEPEIYWVTPAG-------VRL-----------TPARSGRKYRVFPEGTLEL-RRVTA 489

  Fly   532 VVCAVITCLLVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMS 596
            ....:.||:...::|..                       :|::     .::.||.|...|
  Rat   490 EEAGLYTCVAQNLVGAD-----------------------TKTV-----SVVVGHAPFQPG---- 522

  Fly   597 MTLGGGNHVNGLGMTLNYPHHAQTLQAHHHYH-------------------QAMPLQSHG----- 637
                   ...|.|:.|:       :|..|.||                   .|..|:.|.
  Rat   523 -------RDKGPGLELH-------VQETHPYHILLFWAPPPNIVSTNLTWSSAASLRDHETTALA 573

  Fly   638 --GNGNHEYQQTTLPQLDKLELERYLAAQTIA 667
              ..|.|.|..|.|     |....|.|...:|
  Rat   574 RLPRGTHRYNITRL-----LPATEYWACLQVA 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/22 (27%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	22/59 (37%)
		leucine-rich repeat	122..145	CDD:275380	10/22 (45%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	57/192 (30%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	13/46 (28%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	18/60 (30%)
		leucine-rich repeat	339..360	CDD:275380	10/20 (50%)
Lrrn2	NP_001170839.1	LRR_RI	46..288	CDD:238064	78/266 (29%)
		leucine-rich repeat	51..69	CDD:275380	6/18 (33%)
		leucine-rich repeat	71..94	CDD:275380	6/22 (27%)
		leucine-rich repeat	95..118	CDD:275380	8/22 (36%)
		LRR_8	117..177	CDD:290566	22/59 (37%)
		leucine-rich repeat	119..142	CDD:275380	10/22 (45%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		LRR_8	166..222	CDD:290566	16/79 (20%)
		leucine-rich repeat	167..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..214	CDD:275380	9/46 (20%)
		LRR_RI	214..>372	CDD:238064	52/157 (33%)
		LRR_8	214..273	CDD:290566	21/58 (36%)
		leucine-rich repeat	215..238	CDD:275380	8/22 (36%)
		leucine-rich repeat	239..262	CDD:275380	8/22 (36%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		leucine-rich repeat	287..311	CDD:275380	9/23 (39%)
		LRR_8	310..371	CDD:290566	18/60 (30%)
		leucine-rich repeat	312..334	CDD:275380	10/21 (48%)
		leucine-rich repeat	337..360	CDD:275378	3/22 (14%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		TPKR_C2	369..412	CDD:301599	11/57 (19%)
		I-set	430..514	CDD:254352	17/130 (13%)
		Ig	438..514	CDD:299845	16/122 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8997
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010