Protein Alignment Fili and LRRC32

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_005503.1
• Gene: LRRC32 / 2615
• HGNCID: 4161
• Length: 662
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 135/523 - (25%)
• Similarity: 212/523 - (40%)
• Gaps: 133/523 - (25%)

  Fly    23 VLLLLLLTLVILPPETTAFCPSK-------CQCLGGEANSRALCVDAALEDVPIQLNPETKYINL 80
            :||||.|..:.|..:.....|.|       ||.||             |..||..|.|:|:.::|
Human     5 ILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLG-------------LLQVPSVLPPDTETLDL 56

  Fly    81 TVNRIRTLEFS-LPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRN---LVSSLHKHAFK 141
            :.|::|::..| |.||..|..||||.|.|..|....|:..:.|..|:|:.|   :.::|......
Human    57 SGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121

  Fly   142 GLTNLLLLDLSFNRI------------ETVHPTALS-------------DLASLVELDLTNNNIV 181
            .|..:..||||.|.:            .::|..:|:             |:.:|.:|||.:|.::
Human   122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLM 186

  Fly   182 SLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDS----------- 235
            .:||..|:|:..|..|....|.|..:   :.:.|..|:.||:|.|.:|..:..|
Human   187 DIEDGAFEGLPRLTHLNLSRNSLTCI---SDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWL 248

  Fly   236 ------------FEGLKELLALSVQGNVM--------------------SELDLSAFEG------ 262
                        ...|..|:.|::..|::                    |.|.|||..|
Human   249 DLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRP 313

  Fly   263 LISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGN--------RFSQLPAVAFLNLFHLRELHL 319
            |..|.:||||.|.:.::|...|..|::|.:|||..|        |...||.:..|:|.|
Human   314 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSH------ 372

  Fly   320 SRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFP- 383
            :.|:.|: :.:||.   ..|:||.|..| .|.|:|...|....::..:.:|.|.:........|
Human   373 NALETLE-LGARAL---GSLRTLLLQGN-ALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPG 432

  Fly   384 ---------VDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDE 439
                     :..|:.|.|.||.::...:..:|...:|......:||:| .|.||:..|  ||..|
Human   433 PSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE-VATGALGGL--EASLE 494

  Fly   440 ELA 442
            .||
Human   495 VLA 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	93/362 (26%)
		leucine-rich repeat	75..97	CDD:275378	8/22 (36%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		leucine-rich repeat	122..145	CDD:275380	6/25 (24%)
		leucine-rich repeat	146..169	CDD:275380	8/47 (17%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	18/95 (19%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	10/30 (33%)
		leucine-rich repeat	314..338	CDD:275380	4/23 (17%)
		LRR_8	337..397	CDD:404697	17/69 (25%)
		leucine-rich repeat	339..360	CDD:275380	9/20 (45%)
LRRC32	NP_005503.1	LRR_RI	19..277	CDD:238064	67/273 (25%)
		leucine-rich repeat	31..50	CDD:275380	8/31 (26%)
		LRR 1. /evidence=ECO:0000255	50..73		7/22 (32%)
		leucine-rich repeat	51..74	CDD:275380	8/22 (36%)
		LRR 2. /evidence=ECO:0000255	74..95		9/20 (45%)
		leucine-rich repeat	75..98	CDD:275380	9/22 (41%)
		LRR 3. /evidence=ECO:0000255	98..119		5/20 (25%)
		leucine-rich repeat	99..125	CDD:275380	6/25 (24%)
		LRR 4. /evidence=ECO:0000255	125..145		5/19 (26%)
		leucine-rich repeat	126..150	CDD:275380	5/23 (22%)
		LRR 5. /evidence=ECO:0000255	150..171		2/20 (10%)
		leucine-rich repeat	151..174	CDD:275380	3/22 (14%)
		LRR 6. /evidence=ECO:0000255	174..195		8/20 (40%)
		leucine-rich repeat	175..198	CDD:275380	9/22 (41%)
		LRR 7. /evidence=ECO:0000255	198..219		5/23 (22%)
		leucine-rich repeat	199..219	CDD:275380	5/22 (23%)
		leucine-rich repeat	220..244	CDD:275380	7/23 (30%)
		LRR 8. /evidence=ECO:0000255	220..240		7/19 (37%)
		LRR 9. /evidence=ECO:0000255	244..265		0/20 (0%)
		leucine-rich repeat	245..266	CDD:275380	1/20 (5%)
		LRR 10. /evidence=ECO:0000255	266..286		3/19 (16%)
		LRR	290..>574	CDD:443914	62/222 (28%)
		LRR 11. /evidence=ECO:0000255	316..339		8/22 (36%)
		leucine-rich repeat	317..340	CDD:275380	9/22 (41%)
		LRR 12. /evidence=ECO:0000255	340..363		6/22 (27%)
		leucine-rich repeat	341..364	CDD:275380	7/22 (32%)
		LRR 13. /evidence=ECO:0000255	364..385		6/27 (22%)
		leucine-rich repeat	365..387	CDD:275380	7/31 (23%)
		LRR 14. /evidence=ECO:0000255	387..408		9/21 (43%)
		leucine-rich repeat	388..411	CDD:275380	9/23 (39%)
		LRR 15. /evidence=ECO:0000255	411..432		2/20 (10%)
		leucine-rich repeat	412..444	CDD:275380	3/31 (10%)
		LRR 16. /evidence=ECO:0000255	444..465		5/20 (25%)
		leucine-rich repeat	445..463	CDD:275380	5/17 (29%)
		LRR 17. /evidence=ECO:0000255	467..488		7/21 (33%)
		leucine-rich repeat	468..492	CDD:275380	9/26 (35%)
		LRR 18. /evidence=ECO:0000255	492..513		3/6 (50%)
		leucine-rich repeat	493..515	CDD:275380	3/5 (60%)
		PLN03150	<496..654	CDD:178695	2/2 (100%)
		LRR 19. /evidence=ECO:0000255	515..536
		leucine-rich repeat	516..537	CDD:275380
		LRR 20. /evidence=ECO:0000255	537..558
		leucine-rich repeat	538..559	CDD:275380
		leucine-rich repeat	563..575	CDD:275378