Protein Alignment Fili and LRIG1

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_056356.2
• Gene: LRIG1 / 26018
• HGNCID: 17360
• Length: 1093
• Species: Homo sapiens
• Alignment Length: 444
• Identity: 132/444 - (29%)
• Similarity: 199/444 - (44%)
• Gaps: 63/444 - (14%)

  Fly    22 PVLLLLLLTLVILPPETTAF-----CPSKCQCLGG--EANSRALC-------------------- 59
            |.||||.|.|:.|.|.|.|.     |.:.|.|.|.  :...|.|.
Human    16 PCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKL 80

  Fly    60 --VD-AALEDVPIQLNPETKYIN---------------------LTVNRIRTLEFS-LPFYMKLE 99
              :| |..||:|   |.:..|:|                     |..|:||::|.| |..|:.||
Human    81 SEIDPAGFEDLP---NLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLE 142

  Fly   100 ILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLT-NLLLLDLSFNRIETVHPTA 163
            :||||.|.|..:.:..|.:...::.|||:.|.:.:|...||.||: :||.|.||.||| |..|..
Human   143 VLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRI-TQLPVR 206

  Fly   164 LSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLV 228
            ...|..|.:|||..|.|..:|...|:|:|:||||..:.|.:..:.....|.|..:..|.:..|.:
Human   207 AFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSL 271

  Fly   229 EFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYL 293
            ..|.:.|..||..|..|.:..|.::.:....:.....|..|.||.||||.:..:.|::||:|:.|
Human   272 VEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVL 336

  Fly   294 NLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRID--SRAFVDNTHLQTLHLNNNPQLSDIPMR 356
            .|..|..|.:...||..|..||.|.|...:....|:  |.||.....|..|.|..| ::..:..|
Human   337 RLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGN-KIKSVAKR 400

  Fly   357 LFQGNPNILEVYMQSNSLQTL-YSAQFPVDQLQKLYLGDNPLQCNCSLLWL--W 407
            .|.|...:..:.:..|::::: :.|...:..|::|::..:...|:|.|.||  |
Human   401 AFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPW 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	96/301 (32%)
		leucine-rich repeat	75..97	CDD:275378	10/43 (23%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		leucine-rich repeat	122..145	CDD:275380	9/23 (39%)
		leucine-rich repeat	146..169	CDD:275380	11/22 (50%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	9/46 (20%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	8/25 (32%)
		LRR_8	337..397	CDD:404697	11/60 (18%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
LRIG1	NP_056356.2	leucine-rich repeat	51..69	CDD:275380	2/17 (12%)
		LRR	62..414	CDD:443914	105/356 (29%)
		leucine-rich repeat	70..93	CDD:275380	5/25 (20%)
		leucine-rich repeat	117..140	CDD:275378	8/22 (36%)
		leucine-rich repeat	141..164	CDD:275380	9/22 (41%)
		leucine-rich repeat	165..197	CDD:275380	13/31 (42%)
		leucine-rich repeat	213..236	CDD:275380	9/22 (41%)
		leucine-rich repeat	237..260	CDD:275380	7/22 (32%)
		leucine-rich repeat	261..284	CDD:275380	6/22 (27%)
		leucine-rich repeat	285..308	CDD:275380	3/22 (14%)
		leucine-rich repeat	309..332	CDD:275380	10/22 (45%)
		leucine-rich repeat	333..356	CDD:275380	8/22 (36%)
		leucine-rich repeat	357..381	CDD:275380	8/23 (35%)
		leucine-rich repeat	384..405	CDD:275380	6/21 (29%)
		LRR_4	408..445	CDD:463713	4/36 (11%)
		leucine-rich repeat	408..431	CDD:275380	2/22 (9%)
		LRRCT	442..490	CDD:214507	6/13 (46%)
		Ig_3	494..581	CDD:464046
		IgI_LRIG1-like	600..690	CDD:409420
		Ig strand A	600..603	CDD:409420
		Ig strand A'	607..611	CDD:409420
		Ig strand B	614..623	CDD:409420
		Ig strand C	629..634	CDD:409420
		Ig strand C'	637..639	CDD:409420
		Ig strand D	647..651	CDD:409420
		Ig strand E	655..662	CDD:409420
		Ig strand F	668..676	CDD:409420
		Ig strand G	679..690	CDD:409420
		I-set	693..780	CDD:400151
		Ig strand B	710..714	CDD:409353
		Ig strand C	723..727	CDD:409353
		Ig strand E	746..750	CDD:409353
		Ig strand F	760..765	CDD:409353