DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and HMCN2

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001278744.1 Gene:HMCN2 / 256158 HGNCID:21293 Length:5079 Species:Homo sapiens


Alignment Length:399 Identity:82/399 - (20%)
Similarity:126/399 - (31%) Gaps:155/399 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 NRLLDVPAS-----------NLWHLHALKSLDMSLNL-----VEFVRNDSFEGLKEL---LALSV 247
            |.||::|.|           .||.:....|...|:.:     ::|....|.:.|.:|   |...:
Human   272 NVLLNIPDSAKVVAFKPEHPGLWSIKVYSSGRHSVRITGVSNIDFRAGFSTQPLLDLNHTLEWPL 336

  Fly   248 QG----NVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAF 308
            ||    .|::...|.|...|.|::....|...|..:||:.||..|  |:...||..|        
Human   337 QGVPISLVINSTGLKAPGRLDSVELAQSSGKPLLTLPTKPLSNGS--THQLWGGPPF-------- 391

  Fly   309 LNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQT------------------------LHLNNNPQ 349
                     |..:..|..::..:....|..|:.                        ||   .|.
Human   392 ---------HTPKERFYLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLH---QPL 444

  Fly   350 L------SDIPMRL--------------FQ--GNPNILEVYMQSNSLQTLY-------------S 379
            |      |.:|.||              ||  ||.: .|:...|.:.:..|             .
Human   445 LVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSS-WEILRASKAEEGTYECTAVSRAGTGRAK 508

  Fly   380 AQFPVDQ--------------------LQKLYLGDNPLQCNCSLLWL--WRLVTGNFEGVDPGME 422
            ||..|..                    |....||:.|.    :|.|:  ||::.           
Human   509 AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY----NLTWVRDWRVLP----------- 558

  Fly   423 HAAGGAVAALAKEADDEELADEATAVASTDDG----VAALAAYIAEQHIVNALHTTEPSAYELAT 483
             |:.|.||.||      :|:.|.:.:..||.|    ||:.|..:....:  .|...|.....:.|
Human   559 -ASTGRVAQLA------DLSLEISGIIPTDGGRYQCVASNANGVTRASV--WLLVREAPQVSIHT 614

  Fly   484 SSSNRNSGI 492
            ||.:.:.|:
Human   615 SSQHFSQGV 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378
leucine-rich repeat 98..121 CDD:275380
LRR_8 120..180 CDD:404697
leucine-rich repeat 122..145 CDD:275380
leucine-rich repeat 146..169 CDD:275380
LRR <161..>354 CDD:227223 41/204 (20%)
leucine-rich repeat 170..193 CDD:275380
leucine-rich repeat 194..217 CDD:275380 7/25 (28%)
leucine-rich repeat 218..265 CDD:275380 13/58 (22%)
leucine-rich repeat 266..289 CDD:275380 6/22 (27%)
leucine-rich repeat 290..313 CDD:275380 4/22 (18%)
leucine-rich repeat 314..338 CDD:275380 3/23 (13%)
LRR_8 337..397 CDD:404697 22/138 (16%)
leucine-rich repeat 339..360 CDD:275380 11/66 (17%)
HMCN2NP_001278744.1 VWA_2 39..209 CDD:290253
IG_like 434..513 CDD:214653 17/82 (21%)
Ig 442..503 CDD:299845 13/61 (21%)
IG 524..604 CDD:214652 23/103 (22%)
Ig 534..601 CDD:143165 22/90 (24%)
I-set 608..692 CDD:254352 4/16 (25%)
IGc2 621..684 CDD:197706 1/3 (33%)
IG_like 712..782 CDD:214653
Ig 715..779 CDD:143165
Ig 785..869 CDD:299845
IG 792..879 CDD:214652
I-set 885..972 CDD:254352
IGc2 898..962 CDD:197706
IG 988..1063 CDD:214652
Ig 995..1062 CDD:299845
I-set 1079..1161 CDD:254352
IGc2 1088..1151 CDD:197706
I-set 1165..1246 CDD:254352
IGc2 1179..1236 CDD:197706
IG 1258..1340 CDD:214652
Ig 1266..1340 CDD:299845
IG 1354..1433 CDD:214652
IGc2 1360..1423 CDD:197706
IG 1446..1527 CDD:214652
IGc2 1453..1517 CDD:197706
IG 1540..1620 CDD:214652
Ig 1540..1620 CDD:299845
I-set 1632..1716 CDD:254352
IGc2 1641..1704 CDD:197706
IG 1727..1807 CDD:214652
IGc2 1734..1797 CDD:197706
Ig 1820..1893 CDD:299845
IG_like 1827..1891 CDD:214653
I-set 1895..1975 CDD:254352
Ig 1912..1975 CDD:143165
I-set 1986..2076 CDD:254352
IGc2 2001..2066 CDD:197706
Ig 2079..2169 CDD:299845
I-set 2080..2167 CDD:254352
I-set 2171..2261 CDD:254352
IGc2 2185..2251 CDD:197706
I-set 2273..2355 CDD:254352
Ig 2285..2352 CDD:143165
I-set 2367..2449 CDD:254352
Ig 2379..2449 CDD:299845
Ig 2452..2542 CDD:299845
IG_like 2462..2542 CDD:214653
IG 2558..2638 CDD:214652
IGc2 2565..2628 CDD:197706
IG 2656..2736 CDD:214652
IGc2 2663..2726 CDD:197706
IG_like 2770..2847 CDD:214653
IGc2 2773..2837 CDD:197706
IG 2862..2942 CDD:214652
Ig 2868..2942 CDD:299845
IG_like 2954..3034 CDD:214653
IGc2 2961..3024 CDD:197706
I-set 3038..3129 CDD:254352
IGc2 3056..3119 CDD:197706
I-set 3133..3221 CDD:254352
IGc2 3148..3208 CDD:197706
IG 3234..3318 CDD:214652
IGc2 3240..3306 CDD:197706
IG 3329..3410 CDD:214652
IGc2 3336..3400 CDD:197706
IG_like 3424..3499 CDD:214653
IGc2 3430..3489 CDD:197706
I-set 3503..3590 CDD:254352
IGc2 3518..3580 CDD:197706
I-set 3602..3683 CDD:254352
IGc2 3610..3673 CDD:197706
IG 3693..3774 CDD:214652
Ig 3693..3774 CDD:299845
Ig 3777..3859 CDD:299845
IG 3784..3867 CDD:214652
IG_like 3887..3958 CDD:214653
IGc2 3887..3948 CDD:197706
IG 3968..4048 CDD:214652
Ig 3979..4040 CDD:299845
I-set 4052..4139 CDD:254352
IGc2 4065..4129 CDD:197706
I-set 4143..4228 CDD:254352
IGc2 4157..4218 CDD:197706
I-set 4246..4317 CDD:254352
IGc2 4247..4309 CDD:197706
Ig 4322..4405 CDD:299845
I-set 4323..4409 CDD:254352
G2F 4411..4593 CDD:284812
FXa_inhibition 4652..4687 CDD:291342
EGF_CA 4689..4732 CDD:214542
EGF_CA 4733..4774 CDD:284955
EGF_CA 4776..4815 CDD:284955
EGF_CA 4883..4922 CDD:214542
EGF_CA 4923..4963 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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