DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Vasn

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_647468.2	Gene:	Vasn / 246154	MGIID:	2177651	Length:	673	Species:	Mus musculus

Alignment Length:	485	Identity:	133/485 - (27%)
Similarity:	185/485 - (38%)	Gaps:	119/485 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRI 85
            :|.||||||.|:   ......|||.|||   .......|.......||..:.|:|..:.:..|.|
Mouse     7 LPPLLLLLLVLL---GSGVQGCPSGCQC---NQPQTVFCTARQGTTVPRDVPPDTVGLYIFENGI 65

  Fly    86 RTLEF----SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNL 146
            .||:.    .||   .|::||||||.|.:|....|:....|..|:|:.|.:..:....|:||..|
Mouse    66 TTLDVGCFAGLP---GLQLLDLSQNQITSLPGGIFQPLVNLSNLDLTANKLHEISNETFRGLRRL 127

  Fly   147 LLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASN 211
            ..|.|..|||..:.|.|...|..|:||.|.:|.:                      |:|. |.
Mouse   128 ERLYLGKNRIRHIQPGAFDALDRLLELKLPDNEL----------------------RVLP-PL-- 167

  Fly   212 LWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNL 276
              ||..|..||:|.|.:..:.....: ...:.||.:.|..:.:||...|..|::|..||:|||.|
Mouse   168 --HLPRLLLLDLSHNSIPALEAGILD-TANVEALRLAGLGLRQLDEGLFGRLLNLHDLDVSDNQL 229

  Fly   277 TMVPTQQLSKLSNLTYLNLGGN-RFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQ 340
            ..:|: .:..|..||.|.|.|| |.:|           :|...|:.|..||.:|    |.|..||
Mouse   230 EHMPS-VIQGLRGLTRLRLAGNTRIAQ-----------IRPEDLAGLTALQELD----VSNLSLQ 278

  Fly   341 TLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLW 405
            .|.       ||:                         |:.||  :|:.|....||..|.|.|.|
Mouse   279 ALP-------SDL-------------------------SSLFP--RLRLLAAARNPFNCLCPLSW 309

  Fly   406 LWRLVTGNFEGVDPGMEHAAGGAVAALAKEAD-------------DEELADEATAVASTDDGVAA 457
            ....|..|.             .|.|..:|..             |.:.||....|.:|...|..
Mouse   310 FGPWVRENH-------------VVLASPEETRCHFPPKNAGRLLLDLDYADFGCPVTTTTATVPT 361

  Fly   458 LAAYIAEQHI-VNALHTTEPSAYELATSSS 486
            :.:.|.|..: .::...|.||..|..|.:|
Mouse   362 IRSTIREPTLSTSSQAPTWPSLTEPTTQAS 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/25 (28%)
		leucine-rich repeat	98..121	CDD:275380	10/22 (45%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	55/193 (28%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	8/23 (35%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	11/59 (19%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
Vasn	NP_647468.2	LRRNT	24..55	CDD:214470	10/33 (30%)
		leucine-rich repeat	35..57	CDD:275380	5/21 (24%)
		LRR 1	54..75		5/20 (25%)
		LRR_8	58..113	CDD:290566	20/57 (35%)
		leucine-rich repeat	58..78	CDD:275380	6/22 (27%)
		LRR_RI	<76..273	CDD:238064	73/243 (30%)
		LRR_4	77..118	CDD:289563	15/43 (35%)
		LRR 2	78..99		10/20 (50%)
		leucine-rich repeat	79..102	CDD:275380	10/22 (45%)
		LRR_8	102..161	CDD:290566	21/58 (36%)
		LRR 3	102..123		5/20 (25%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		LRR 4	126..147		8/20 (40%)
		leucine-rich repeat	127..150	CDD:275380	9/22 (41%)
		LRR 5	150..170		9/46 (20%)
		leucine-rich repeat	151..194	CDD:275380	15/70 (21%)
		LRR 6	171..192		5/21 (24%)
		LRR_8	194..250	CDD:290566	20/56 (36%)
		LRR 7	194..215		6/20 (30%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		LRR 8	218..239		8/21 (38%)
		leucine-rich repeat	219..241	CDD:275380	9/22 (41%)
		LRR_8	240..301	CDD:290566	27/109 (25%)
		LRR 9	241..265		10/34 (29%)
		leucine-rich repeat	242..266	CDD:275380	11/34 (32%)
		LRR 10	266..288		11/57 (19%)
		LRRCT	299..350	CDD:214507	14/63 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..389		4/19 (21%)
		EGF	410..441	CDD:278437
		fn3	468..537	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100