DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fili and Tsku

DIOPT Version :9

Sequence 1:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_001019790.1 Gene:Tsku / 244152 MGIID:2443855 Length:354 Species:Mus musculus


Alignment Length:320 Identity:90/320 - (28%)
Similarity:143/320 - (44%) Gaps:49/320 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LCGAIPVLLLLLLTLVILPPETTAFCPSKCQC---LGGEANSRAL----CVDAALEDVPIQLNPE 74
            ||.      |.||.|.:...:||..|...|||   ..|..:|.:|    |.......||:.:..:
Mouse     2 LCS------LFLLLLAVGRVQTTRPCFPGCQCEEETFGLFDSFSLIRVDCSSLGPHIVPVPIPLD 60

  Fly    75 TKYINLTVNRIRTLEFSL---PFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLH 136
            |.:::|:.||:.|:..|:   |.|..|..||||.|::.::....|.....|.:|:||.|.:::|.
Mouse    61 TAHLDLSSNRLETVNESVLAGPGYTTLAGLDLSYNLLTSIMPSAFSRLRYLESLDLSHNGLAALP 125

  Fly   137 KHAFKGLTNLLLLDLSFNRIETVHPTALS--DLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVF 199
            ...|.. :.|..::||.||:..|..:|.:  .....:.:||::|.|                   
Mouse   126 AEIFTS-SPLSDINLSHNRLREVSISAFTTHSQGRALHVDLSHNLI------------------- 170

  Fly   200 RNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKE--LLALSVQGNVMSELDLSAFEG 262
              :|||..||........::||::|.|     |..:...|::  |..||:.||.::.::..||.|
Mouse   171 --HRLLPHPARASLPAPTIQSLNLSWN-----RFRAVPDLRDLPLRYLSLDGNPLATINPDAFMG 228

  Fly   263 LISLKHLDLSD-NNLTMVPTQQLSKLSNLTYLNLGGN-RFSQLPAVAFLNLFHLRELHLS 320
            |..|.||.|:. ..:..:|.....:|..|..|:|.|| :.....|..|..|..|:||.||
Mouse   229 LAGLTHLSLASLQGILHLPPHGFRELPGLQVLDLSGNPKLKWAGAEVFSGLGLLQELDLS 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 8/24 (33%)
leucine-rich repeat 98..121 CDD:275380 7/22 (32%)
LRR_8 120..180 CDD:404697 17/61 (28%)
leucine-rich repeat 122..145 CDD:275380 7/22 (32%)
leucine-rich repeat 146..169 CDD:275380 7/24 (29%)
LRR <161..>354 CDD:227223 44/166 (27%)
leucine-rich repeat 170..193 CDD:275380 4/22 (18%)
leucine-rich repeat 194..217 CDD:275380 5/22 (23%)
leucine-rich repeat 218..265 CDD:275380 15/48 (31%)
leucine-rich repeat 266..289 CDD:275380 6/23 (26%)
leucine-rich repeat 290..313 CDD:275380 8/23 (35%)
leucine-rich repeat 314..338 CDD:275380 5/7 (71%)
LRR_8 337..397 CDD:404697
leucine-rich repeat 339..360 CDD:275380
TskuNP_001019790.1 LRR 1 60..81 6/20 (30%)
leucine-rich repeat 63..86 CDD:275380 7/22 (32%)
LRR <64..317 CDD:227223 71/252 (28%)
LRR 2 86..107 7/20 (35%)
leucine-rich repeat 87..110 CDD:275380 7/22 (32%)
LRR 3 110..131 7/20 (35%)
leucine-rich repeat 111..132 CDD:275380 7/21 (33%)
LRR 4 133..154 7/20 (35%)
leucine-rich repeat 134..186 CDD:275380 16/72 (22%)
leucine-rich repeat 158..182 CDD:275380 9/44 (20%)
LRR 5 160..180 9/40 (23%)
LRR 6 186..207 6/25 (24%)
leucine-rich repeat 187..205 CDD:275380 6/22 (27%)
leucine-rich repeat 208..231 CDD:275380 9/22 (41%)
LRR 7 208..228 7/19 (37%)
LRR 8 231..253 5/21 (24%)
leucine-rich repeat 232..256 CDD:275380 6/23 (26%)
LRR 9 256..277 6/20 (30%)
leucine-rich repeat 257..281 CDD:275380 8/23 (35%)
LRR 10 281..302 5/8 (63%)
leucine-rich repeat 282..305 CDD:275380 5/7 (71%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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