Protein Alignment Fili and Lingo2

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_780725.2
• Gene: Lingo2 / 242384
• MGIID: 2442298
• Length: 606
• Species: Mus musculus
• Alignment Length: 394
• Identity: 122/394 - (30%)
• Similarity: 190/394 - (48%)
• Gaps: 39/394 - (9%)

  Fly    20 AIPVLLLLL-LTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVN 83
            |||.....| |.:|:|...:|..||::|:|  ...|....|....|..:|..:..|||.::|:.|
Mouse     5 AIPCWQPFLGLAVVLLLMGSTIGCPARCEC--SAQNKSVSCHRRRLLAIPEGIPIETKILDLSKN 67

  Fly    84 RIRTL---EF-SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLT 144
            |::::   || |.|.   ||.:|||.|||..:....|.....||:|.|..|.:..:....|.||:
Mouse    68 RLKSINPEEFISYPL---LEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLS 129

  Fly   145 NLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPA 209
            ||..||:|.|:|..:......||.:|..|::.:|::|.:....|.|:.:||.|......|..||.
Mouse   130 NLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPT 194

  Fly   210 SNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSD- 273
            ..|.|                        |:.|:||.::...::.:.:.||:.|..||:|::..
Mouse   195 EALSH------------------------LRSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYW 235

  Fly   274 NNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTH 338
            ..|.::|...|..| |||.|::.....|.:|.:||.:|.:|..|:|| .:.:..|::..|.|...
Mouse   236 PLLDLMPANSLYGL-NLTSLSITNTNLSTVPFLAFKHLVYLTHLNLS-YNPISTIEAGMFSDLIR 298

  Fly   339 LQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQ-LQKLYLGDNPLQCNCS 402
            ||.||: ...||..|....|||...:..:.:..|.|:||....|...: |:.|.:.:|||.|:|.
Mouse   299 LQELHI-VGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCR 362

  Fly   403 LLWL 406
            ||||
Mouse   363 LLWL 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	84/281 (30%)
		leucine-rich repeat	75..97	CDD:275378	9/25 (36%)
		leucine-rich repeat	98..121	CDD:275380	9/22 (41%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	7/46 (15%)
		leucine-rich repeat	266..289	CDD:275380	7/23 (30%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	7/23 (30%)
		LRR_8	337..397	CDD:404697	18/60 (30%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
Lingo2	NP_780725.2	LRRNT	27..60	CDD:214470	9/34 (26%)
		leucine-rich repeat	39..57	CDD:275380	3/17 (18%)
		LRR	48..>340	CDD:443914	96/321 (30%)
		LRR 1	58..79		8/20 (40%)
		leucine-rich repeat	59..82	CDD:275380	8/22 (36%)
		LRR 2	82..103		9/23 (39%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR 6	178..199		7/20 (35%)
		leucine-rich repeat	179..202	CDD:275380	9/46 (20%)
		LRR 7	202..223		5/20 (25%)
		leucine-rich repeat	203..250	CDD:275380	13/47 (28%)
		LRR 8	226..247		5/20 (25%)
		LRR 9	250..271		8/20 (40%)
		leucine-rich repeat	251..274	CDD:275380	8/22 (36%)
		LRR 10	274..295		6/21 (29%)
		leucine-rich repeat	275..298	CDD:275380	7/23 (30%)
		LRR 11	298..319		8/21 (38%)
		leucine-rich repeat	299..322	CDD:275380	10/23 (43%)
		LRR 12	322..343		5/20 (25%)
		leucine-rich repeat	323..343	CDD:275380	5/19 (26%)
		PCC	327..>391	CDD:188093	16/40 (40%)
		Ig	411..500	CDD:472250
		Ig strand B	428..432	CDD:409353
		Ig strand C	441..445	CDD:409353
		Ig strand E	466..470	CDD:409353
		Ig strand F	480..485	CDD:409353
		Ig strand G	493..496	CDD:409353