DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Lingo3

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001013780.2	Gene:	Lingo3 / 237403	MGIID:	3609246	Length:	589	Species:	Mus musculus

Alignment Length:	480	Identity:	137/480 - (28%)
Similarity:	211/480 - (43%)	Gaps:	76/480 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LLLLLLTLVILP-PETTAFCPSKCQCLGGEANSRAL-CVDAALEDVPIQLNPETKYINLTVNRIR 86
            |.:|.|.|::|| ....|.||::|:|   .|::|.: |....|..:|..:..||:.:.|:.||||
Mouse     5 LHMLGLHLLLLPTAPLAAGCPARCEC---SASTRTVACGRRRLTAIPEGIPAETRMLELSRNRIR 66

  Fly    87 TLE----FSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLL 147
            .|.    .|||   .||.|||:.|:|..:....|.....||.|.|..|.:..:....|..|.:|.
Mouse    67 CLNPGDLASLP---TLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHLDSLT 128

  Fly   148 LLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNL 212
            |||||.|::..:...:..||.||..|::.:|::|.:....|.|:..|..|......|..:...:|
Mouse   129 LLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGLLGLAELTLERCNLTSLSPESL 193

  Fly   213 WHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQG-NVMSELDLSAFEGLISLKHLDLSDNNL 276
            .||..|.:|.:....:..:.:.:|:.|..|..|.:.. .::.|:...:..|| :|..|.::..|:
Mouse   194 GHLRGLGALRLRHLAIAALEDQNFQKLPGLSHLEIDNWPLLEEVAPGSLRGL-NLTSLSITHTNI 257

  Fly   277 TMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQT 341
            |.||...|.:.::||.|||..|..|.:|..:|.:|..||||||:.. .|..|:.:|||....::.
Mouse   258 TAVPAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGA-LLAVIEPQAFVGLRQIRL 321

  Fly   342 LHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLLW 405
            |:|::                         |.|.||....| .|:.|:.|.:..|||.|:|.|||
Mouse   322 LNLSD-------------------------NLLSTLEENTFHSVNTLETLRVDGNPLACDCRLLW 361

  Fly   406 L-WRLVTGNFEGVDPGMEHAA---GGAVAAL-------------------------AKEADDEEL 441
            : .|..|.||:|..|.....|   |.|:..|                         |.|.||...
Mouse   362 IVQRRKTLNFDGRLPACATPAEVRGDALHNLPDSVLFEYFVCRKPKIRERRLQHVTATEGDDVRF 426

  Fly   442 ADEATAVASTDDGVAALAAYIAEQH 466
                  :...:...|...|::..||
Mouse   427 ------LCRAEGEPAPTVAWVTPQH 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	10/25 (40%)
		leucine-rich repeat	98..121	CDD:275380	8/22 (36%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	9/22 (41%)
		LRR	<161..>354	CDD:227223	54/193 (28%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	9/47 (19%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		leucine-rich repeat	314..338	CDD:275380	11/23 (48%)
		LRR_8	337..397	CDD:404697	11/60 (18%)
		leucine-rich repeat	339..360	CDD:275380	2/20 (10%)
Lingo3	NP_001013780.2	LRRNT	23..55	CDD:214470	9/34 (26%)
		leucine-rich repeat	34..53	CDD:275380	4/18 (22%)
		LRR 1	54..75		8/20 (40%)
		LRR	<55..353	CDD:227223	95/327 (29%)
		leucine-rich repeat	55..78	CDD:275380	10/25 (40%)
		LRR 2	78..99		8/20 (40%)
		leucine-rich repeat	79..102	CDD:275380	8/22 (36%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..150	CDD:275380	16/46 (35%)
		LRR 4	126..147		7/20 (35%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		LRR 6	174..195		4/20 (20%)
		leucine-rich repeat	175..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR 7	206..227		3/20 (15%)
		leucine-rich repeat	223..246	CDD:275380	5/23 (22%)
		LRR_8	246..302	CDD:338972	23/55 (42%)
		LRR 8	246..267		7/20 (35%)
		leucine-rich repeat	247..270	CDD:275380	7/22 (32%)
		LRR 9	270..291		9/20 (45%)
		leucine-rich repeat	271..292	CDD:275380	9/20 (45%)
		LRR 10	294..315		10/21 (48%)
		leucine-rich repeat	295..318	CDD:275380	11/23 (48%)
		LRR 11	318..339		7/45 (16%)
		leucine-rich repeat	321..342	CDD:275380	8/45 (18%)
		PCC	331..>405	CDD:188093	24/73 (33%)
		I-set	406..496	CDD:369462	8/46 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010