DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Nyx

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_775591.1	Gene:	Nyx / 236690	MGIID:	2448607	Length:	476	Species:	Mus musculus

Alignment Length:	557	Identity:	143/557 - (25%)
Similarity:	219/557 - (39%)	Gaps:	114/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLLLLLLTLVILPPETTA------FCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLT 81
            :|:|||..:|...|.|.|      .||:.|.|...|......|..|.|:.||.:
Mouse     1 MLILLLHAVVFSLPYTRATEACLRACPAACTCSHVERGCSVRCDRAGLQRVPQE----------- 54

  Fly    82 VNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNL 146
                        |..:...:||.:|.:..||.:.|.....||.|:|..|.:|.:...|||||..|
Mouse    55 ------------FPCEAASIDLDRNGLRILGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRL 107

  Fly   147 LLLDLSFN-RIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPA- 209
            ..|.|:.| .:..:|....:.|..|..|||....:.|:.:.....:..|..|...:|....||.
Mouse   108 AELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPERLLAELPALRELTAFDNLFRRVPGA 172

  Fly   210 ----SNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLD 270
                :||.|.|..:|      .:|.|.:.|..|::.|.:||:|.|.:..:...||....:|:.|.
Mouse   173 LRGLANLTHAHFERS------RIEAVASGSLLGMRRLRSLSLQANRVRAVHAGAFGDCGALEDLL 231

  Fly   271 LSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVD 335
            |:||.|..:|......|..|..||||||....:....|.:|..|..|:|.| :.:..::..||.:
Mouse   232 LNDNLLATLPAAAFRGLRRLRTLNLGGNALGSVARAWFSDLAELELLYLDR-NSITFVEEGAFQN 295

  Fly   336 NTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCN 400
            .:.|..||||.| :|:.:....||                       |...|.:|:|..||.:|:
Mouse   296 LSGLLALHLNGN-RLTVLSWAAFQ-----------------------PGFFLGRLFLFRNPWRCD 336

  Fly   401 CSLLWL--WRLVTGNFEGV---DPGMEHAAGGAVAALAKEADDEELA---DEATAVASTDDGVAA 457
            |.|.||  |...:|....|   .||  ..||..::.:..|...:.|.   ||.....|:..
Mouse   337 CQLEWLRDWMEGSGRVADVACASPG--SVAGQDLSQVVFERSSDGLCVDPDELNFTTSSPG---- 395

  Fly   458 LAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGIL------RMDRQQIGCDIWRDKVRTRRKLL 516
                              ||...:||:.| |.|.:|      |...:::....|        :|:
Mouse   396 ------------------PSPEPVATTVS-RFSSLLSKLLAPRAPVEEVANTTW--------ELV 433

  Fly   517 TMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYL 553
            .:|..: :..:|.|.|.|...|.|..:.:.:|:..|:
Mouse   434 NVSLND-SFRSHAVMVFCYKATFLFTSCVLLSLAQYV 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	1/21 (5%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	21/60 (35%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	6/23 (26%)
		LRR	<161..>354	CDD:227223	57/197 (29%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	8/27 (30%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	14/59 (24%)
		leucine-rich repeat	339..360	CDD:275380	8/20 (40%)
Nyx	NP_775591.1	LRRNT	25..56	CDD:214470	10/53 (19%)
		LRR 1	58..79		6/20 (30%)
		LRR_8	61..115	CDD:338972	20/53 (38%)
		leucine-rich repeat	63..82	CDD:275380	6/18 (33%)
		LRR_RI	<68..312	CDD:393385	76/251 (30%)
		LRR 2	82..103		8/20 (40%)
		leucine-rich repeat	83..106	CDD:275380	11/22 (50%)
		LRR 3	106..128		5/21 (24%)
		leucine-rich repeat	107..131	CDD:275380	6/23 (26%)
		LRR 4	131..154		5/22 (23%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		LRR 5	155..177		5/21 (24%)
		leucine-rich repeat	156..178	CDD:275380	5/21 (24%)
		LRR 6	178..199		8/26 (31%)
		leucine-rich repeat	179..202	CDD:275380	8/28 (29%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR 8	226..247		7/20 (35%)
		leucine-rich repeat	227..250	CDD:275380	8/22 (36%)
		LRR_8	250..309	CDD:338972	21/60 (35%)
		LRR 9	250..271		8/20 (40%)
		leucine-rich repeat	251..274	CDD:275380	9/22 (41%)
		LRR 10	274..295		6/21 (29%)
		leucine-rich repeat	275..296	CDD:275380	6/21 (29%)
		LRR 11	298..319		9/44 (20%)
		leucine-rich repeat	299..322	CDD:275378	10/46 (22%)
		leucine-rich repeat	323..335	CDD:275378	5/11 (45%)
		LRRCT	331..>366	CDD:214507	13/36 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100